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Formulation of betacyclodextrin based nanosponges of itraconazole

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Abstract

Nanosponges are betacyclodextrins crosslinked with carbonate bonds. The polymer formed is nanoparticulate in nature. Itraconazole is a BCS Class II drug that has a dissolution rate limited poor bioavailability. Rationale of the work was to enhance the solubility of Itraconazole so that the bioavailability problems are solved. Solid dispersion technique has been used for drug incorporation. The effect of a ternary component copolyvidonum on solubility of itraconazole has been studied. Phase solubility studies has been carried out with a rationale of comparing the solubilization efficiency of nanosponges, copolyvidonum and combination. The dispersions were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and photon correlation spectroscopy (PCS). It was found that the solubility of itraconazole was enhanced more than 50-folds with a ternary solid dispersion system. Using copolyvidonum in conjunction with nanosponges helps to increase the solubilization efficiency of nanosponges as evident from the phase solubility studies.

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Authors and Affiliations

  1. Pharmaceutical Division, Mumbai University Institute of Chemical Technology, Matunga, Mumbai, 400019, India

    Shankar Swaminathan, P. R. Vavia & Satyen Torne

  2. Departimento di Chemica IFM, Universita degli studi di Torino, Via Pietro Giuria 7, Torino, 10125, Italy

    Francesco Trotta

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  1. Shankar Swaminathan
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  2. P. R. Vavia
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  3. Francesco Trotta
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  4. Satyen Torne
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Correspondence to P. R. Vavia.

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Swaminathan, S., Vavia, P.R., Trotta, F. et al. Formulation of betacyclodextrin based nanosponges of itraconazole. J Incl Phenom Macrocycl Chem 57, 89–94 (2007). https://doi.org/10.1007/s10847-006-9216-9

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  • DOI: https://doi.org/10.1007/s10847-006-9216-9

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