Skip to main content
Log in

Computational aspects of the three-dimensional feature-scale simulation of silicon-nanowire field-effect sensors for DNA detection

  • Published:
Journal of Computational Electronics Aims and scope Submit manuscript

Abstract

In recent years dna-sensors, and generally biosensors, with semiconducting transducers were fabricated and characterized. Although the concept of so-called Biofets was proposed already two decades ago, its realization has become feasible only recently due to advances in process technology. In this paper a comprehensive and rigorous approach to the simulation of silicon-nanowire dnafets at the feature-scale is presented. It allows to investigate the feasibility of single-molecule detectors and is used to elucidate the performance that can be expected from sensors with nanowire diameters in the deca-nanometer range. Finally the computational challenges for the simulation of silicon-nanowire dna-sensors are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bergveld, P.: Development of an ion-sensitive solid-state device for neurophysiological measurements. IEEE Trans. Biomed. Eng. BME-17, 70 (1970)

    Google Scholar 

  2. Bergveld, P.: Development, operation and application of the ion sensitive field effect transistor as a tool for electrophysiology. IEEE Trans. Biomed. Eng. BME-19, 342 (1972)

    Article  Google Scholar 

  3. Zheng, G., et al.: Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nature Biotechnology 23, 1294 (2005)

    Article  Google Scholar 

  4. Yang, C., et al.: Encoding electronic properties by synthesis of axial modulation-doped silicon nanowires. Science 310, 1304 (2005)

    Article  Google Scholar 

  5. Klemic, J., et al.: Hotwiring biosensors. Nature Biotechnology 19, 924 (2001)

    Article  Google Scholar 

  6. Premilat, S., Albiser, G.: Conformations of A-DNA and B-DNA in agreement with fiber X-ray and infrared dichroism. Nucleic Acids Res. 11(6), 1897 (1983)

    Article  Google Scholar 

  7. van der Spoel, D., et al.: Gromacs User Manual version 3.2 (2004), http://www.gromacs.org

  8. Berman, H., et al.: The protein data bank. Nucleic Acids Res. 28, 235 (2000)

    Article  Google Scholar 

  9. Baker, N., et al.: Electrostatics of nanosystems: Application to microtubules and the ribosome. Proc. Nat. Acad. Sci. USA 98(18), 10037 (2001)

    Article  Google Scholar 

  10. Datta, S.: Quantum transport: atom to transistor, 2nd edition. Cambridge University Press Cambridge (2005)

  11. Wang, J., et al.: A three-dimensional quantum simulation of silicon nanowire transistors with the effective-mass approximation. J. Appl. Phys. 96(4) (2004)

  12. Wagner, R., Ellis, W.: Vapor-liquid-solid mechanism of single crystal growth. Appl. Phys. Lett. 4(5), 89 (1964)

    Article  Google Scholar 

  13. Hahm, J., Lieber, C.: Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Lett. 4(1), 51 (2004)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Clemens Heitzinger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heitzinger, C., Klimeck, G. Computational aspects of the three-dimensional feature-scale simulation of silicon-nanowire field-effect sensors for DNA detection. J Comput Electron 6, 387–390 (2007). https://doi.org/10.1007/s10825-006-0139-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10825-006-0139-x

Keywords

Navigation