Abstract
In recent years dna-sensors, and generally biosensors, with semiconducting transducers were fabricated and characterized. Although the concept of so-called Biofets was proposed already two decades ago, its realization has become feasible only recently due to advances in process technology. In this paper a comprehensive and rigorous approach to the simulation of silicon-nanowire dnafets at the feature-scale is presented. It allows to investigate the feasibility of single-molecule detectors and is used to elucidate the performance that can be expected from sensors with nanowire diameters in the deca-nanometer range. Finally the computational challenges for the simulation of silicon-nanowire dna-sensors are discussed.
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Bergveld, P.: Development of an ion-sensitive solid-state device for neurophysiological measurements. IEEE Trans. Biomed. Eng. BME-17, 70 (1970)
Bergveld, P.: Development, operation and application of the ion sensitive field effect transistor as a tool for electrophysiology. IEEE Trans. Biomed. Eng. BME-19, 342 (1972)
Zheng, G., et al.: Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nature Biotechnology 23, 1294 (2005)
Yang, C., et al.: Encoding electronic properties by synthesis of axial modulation-doped silicon nanowires. Science 310, 1304 (2005)
Klemic, J., et al.: Hotwiring biosensors. Nature Biotechnology 19, 924 (2001)
Premilat, S., Albiser, G.: Conformations of A-DNA and B-DNA in agreement with fiber X-ray and infrared dichroism. Nucleic Acids Res. 11(6), 1897 (1983)
van der Spoel, D., et al.: Gromacs User Manual version 3.2 (2004), http://www.gromacs.org
Berman, H., et al.: The protein data bank. Nucleic Acids Res. 28, 235 (2000)
Baker, N., et al.: Electrostatics of nanosystems: Application to microtubules and the ribosome. Proc. Nat. Acad. Sci. USA 98(18), 10037 (2001)
Datta, S.: Quantum transport: atom to transistor, 2nd edition. Cambridge University Press Cambridge (2005)
Wang, J., et al.: A three-dimensional quantum simulation of silicon nanowire transistors with the effective-mass approximation. J. Appl. Phys. 96(4) (2004)
Wagner, R., Ellis, W.: Vapor-liquid-solid mechanism of single crystal growth. Appl. Phys. Lett. 4(5), 89 (1964)
Hahm, J., Lieber, C.: Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Lett. 4(1), 51 (2004)
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Heitzinger, C., Klimeck, G. Computational aspects of the three-dimensional feature-scale simulation of silicon-nanowire field-effect sensors for DNA detection. J Comput Electron 6, 387–390 (2007). https://doi.org/10.1007/s10825-006-0139-x
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DOI: https://doi.org/10.1007/s10825-006-0139-x