Skip to main content
SpringerLink
Log in

Investigations on 5-(2-aryl-2-oxo-ethylidene)-1,3-dimethylbarbituric and thiobarbituric acids: reactions with thioureas and thioacetamide

  • Published:
Chemistry of Heterocyclic Compounds Aims and scope

Derivatives of 2-amino- and 2-methylthiazole have been synthesized by the reaction of 5-(2-aryl-2-oxoethylidene)-1,3-dimethylbarbituric and thiobarbituric acids with thioureas and thioacetamide, and also by a one-pot synthesis involving thiourea (or thioacetamide), arylglyoxals, 1,3-dimethyl-barbituric (or thiobarbituric) acids. The mechanisms of the studied reactions are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. Joule and K. Mills, Chemistry of Heterocyclic Compounds [Russian translation], Mir, Moscow, 2004

    Google Scholar 

  2. M. R. Mahmound and H. M. F. Markour, Synth. Commun., 26, 3799 (1996).

    Article  Google Scholar 

  3. H. H. Sayed, Indian J. Chem., 37B, 1054 (1998).

    CAS  Google Scholar 

  4. G. Osske, D. Szabo, and T. Lorand, Pharmazie, 43, 164 (1988).

    CAS  Google Scholar 

  5. P. Perjesi, G. Batta, and A. Foeldesi, Monatsh. Chem., 125, 433 (1994).

    Article  CAS  Google Scholar 

  6. M. Augustin and P. Jechke, J. Prakt. Chem., 329, 626 (1987).

    Article  CAS  Google Scholar 

  7. H. Singh, S. Kumar, and P. Singh, J. Chem. Res. (miniprint), 1641 (1984).

  8. L. Gozalishvili, T. Beryozkina, I. Omelchenko, R. Zubatyuk, O. Shishkin, and N. Kolos, Tetrahedron, 64, 8759 (2008).

    Article  CAS  Google Scholar 

  9. N. N. Kolos, V. D. Orlov, E. Ya. Yuzefovskaya, F. G. Yaremenko, N. P. Vorob’eva, O. V. Shishkin, Yu. T. Struchkov, and S. M. Ivkov, Khim. Geterotsikl. Soedin., 950 (1995). [Chem. Heterocycl. Comp., 31, 827 (1995)].

    Google Scholar 

  10. N. N. Kolos, V. D. Orlov, D. Arisa, O. V. Shishkin, Yu. T. Struchkov, and N. P. Vorob’eva, Khim. Geterotsikl. Soedin., 87 (1996). [Chem. Heterocycl. Comp., 32, 78 (1996)].

    Google Scholar 

  11. N. N. Kolos, V. D. Orlov, V. A. Chebanov, O. V. Shishkin, V. P. Kuznetsov, and A. Yu. Kulikov, Khim. Geterotsikl. Soedin., 978 (1996). [Chem. Heterocycl. Comp., 32, 838 (1996)].

    Google Scholar 

  12. K. Weygand and G. Hilgetag, Organisch-chemische Verkunst, Verlag, Berlin (1964). [Experimental Methods in Organic Chemistry [Russian translation], Khimiya, Moscow (1968)].

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemical Faculty V. N. Karazin Kharkiv National University, Kharkiv, 61077, Ukraine

    N. N. Kolos & L. L. Zamigaylo

  2. Institute for Single Crystals, National Academy of Sciences of Ukraine, Kharkiv, 61001, Ukraine

    V. I. Musatov

Authors
  1. N. N. Kolos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. L. Zamigaylo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. I. Musatov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. N. Kolos.

Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1220–1226, August, 2009.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kolos, N.N., Zamigaylo, L.L. & Musatov, V.I. Investigations on 5-(2-aryl-2-oxo-ethylidene)-1,3-dimethylbarbituric and thiobarbituric acids: reactions with thioureas and thioacetamide. Chem Heterocycl Comp 45, 970–975 (2009). https://doi.org/10.1007/s10593-009-0365-9

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10593-009-0365-9

Keywords

Search

Navigation