Abstract
Fe3O4/Au (GoldMag) particles with core/shell structure were synthesized by reduction of Au3+ with hydroxylamine in the presence of Fe3O4. The synthesized particles have an average size smaller than 100 nm in diameter with of superparemagnetic properties due to their Fe oxide cores. The particles show optical features with a plasmon resonance peak from 550, 570 to 590 nm correlating with increasing diameters from 50 nm, 70 nm to 100 nm.The GoldMag particles need only a single step for antibody immobilization and have high binding capacity for antibodies. These advantages permit improved methods of isolating and detecting biomolecules.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
R. Caldarelli-Stefano, L. Vago, S. Bonetto, M. Nebuloni, and G. Costanzi, Journal of Clinical Pathology: Molecular Pathology 52(3), 158–160 (1999).
Y.L. Cui, D.D. Hu, Y. Fang, and J.B. Ma, Science in China (Series B) 44(4), 404–410 (2001).
Y.L. Cui, W.L. Hui, H.R. Wang, L.J. Wang, and C. Chen, Science in China (Series B) 47(2), 152–158 (2004).
W.P. Faulk and G.M.Taylor, Immunochem 8, 1081–1083 (1971).
C. Grüttner and J. Teller, J Magnetism Magnetic Mater 194(1–3): 8–15 (1999).
R.C Jin, G.S. Wu, Z. Li, C.A. Mirkin, and G.C. Schatz, J. Am. Chem. Soc. 125(6), 1643–1654 (2003).
T. Kinoshita, S. Seino, K. Okitsu, T. Nakayama, T. Nakagawa, and T.A. Yamamoto, Journal of Alloys and Compounds 359, 46–50 (2003).
U. Kreibig, Sruface Science 156, 678–700 (1985).
J.L. Lyon, D.A. Fleming, M.B. Stone, P. Schiffer, and M.E. Williams, Nano Letters 4(4): 719–723 (2004).
V.M. Martin, C. Siewert, A. Scharl et al., Exp Hematol 26, 252–264 (1998).
C.A. Mirkin, R.L. Letsinger, R.C. Mucic, and J.J. Storhoff, Nature 382, 607–609 (1996).
F. Patolsky, Y. Weizmann et al., Angew. Chem. Int. Ed. 42, 2372–2376 (2003).
I. Safarik, L. Ptackova, M. Safarikova, Biotechnology Letters 23, 1953–1956 (2001).
J.J. Storhoff, A.A. Lazaorides, R.C. Mucic, C.A. Mirkin, R.L. Letsinger, and G.C. Schatz, J. Am. Chem. Soc. 122, 4640–4650 (2000).
T.A. Taton, C.A. Mirkin, and R.L. Letsinger, Science 289, 1757–1760 (2000).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cui, Y., Wang, Y., Hui, W. et al. The Synthesis of GoldMag Nano-Particles and their Application for Antibody Immobilization. Biomed Microdevices 7, 153–156 (2005). https://doi.org/10.1007/s10544-005-1596-x
Issue Date:
DOI: https://doi.org/10.1007/s10544-005-1596-x