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Study of the impact of CT/CT image fusion radiotherapy on V20 and radiation pneumonitis of non-small cell lung cancer

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

The aim of our study was to investigate the value of CT/CT image fusion radiation treatment planning in non-small cell lung cancer (NSCLC) and the impact on V20 and radiation pneumonitis (RP).

Methods

Patients who were pathologically or cytologically diagnosed of stage IIIA and IIIB NSCLC were treated with three-dimensional conformal radiation therapy (4000 cGy). Forty patients got at least 25% tumor reduction were randomly divided into two groups: group A of regular shrink field radiotherapy (20 cases) and group B of CT/CT image fused shrink field radiotherapy (20 cases). Dosage reached 6600 cGy. Clinical data, V20 and RP were observed within 3 months after radiotherapy. Statistical analysis was conducted for the NSCLC patients.

Results

22.5% (9/40) patients got RP during follow-up. Group A accounted for 6 cases (30%), and group B had 3 cases (15%). There was no marked difference between the two groups (P = 0.256), univariate analysis revealed that the IV20 of A and B groups, and IV20 and CV20 of all patients were statistically related to the incidence of RP (P < 0.05). With Wilcoxon method assay, the ipsilateral lung V20 and contralateral lung V20 had statistical significance between the two groups (P < 0.05).

Conclusion

The CT/CT image infusion treatment planning could increase the radical dosage with better tumor control probability but won’t increase adverse reaction.

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References

  1. Nagata Y, Negoro Y, Aoki T, et al. Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame. Int J Radiat Onol Biol Phys, 2002, 52: 1041–1046.

    Article  Google Scholar 

  2. Sim S, Rosenzweig KE, Schindelheim R, et al. Induction chemotherapy plus three-dimensional conformal radiation therapy in the definitive treatment of locally advanced non-small-cell lung cancer. Int J Radiat Oncol Biol Phys, 2001, 51: 660–665.

    Article  PubMed  CAS  Google Scholar 

  3. Tsujino K, Hirota S, Endo M, et al. Predictive value of dose-volume histogram parameters for predicting radiation pneumonitis after concurrent chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys, 2003, 55: 110–115.

    Article  PubMed  Google Scholar 

  4. Zhu XZ, Wang LH, Wang YJ, et al. Risk factors for radiation pneumonitis in stage III non-small-cell lung cancer treated with three-dimensional conformal radiotherapy. Chin J Radiat Oncol (Chinese), 2007, 16: 421–426.

    Google Scholar 

  5. Hernando ML, Marks LB, Bentel GC, et al. Radiation induced pulmonary toxicity: a dose volume histogram analysis in 201 patients with lung cancer. Int J Radiat Oncol Biol Phys, 2001, 51: 650–659.

    Article  PubMed  CAS  Google Scholar 

  6. Yorke ED, Jackson A, Rosenzweig KE, et al. Correlation of dosimetric factors and radiation pneumonitis for non-small-cell lung cancer patients in a recently completed dose escalation study. Int J Radiat Oncol Biol Phys, 2005, 63: 672–682.

    Article  PubMed  Google Scholar 

  7. Graham MV, Purdy JA, Emami B, et al. Clinical dose-volume histogram analysis for peneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys, 1999, 45: 323–329.

    PubMed  CAS  Google Scholar 

  8. Yang LQ, Wu LP, Chen LJ, et al. Value of V20 and V30 parameters for predicting acute radiation lung toxicity after 3D radiotherapy for lung cancer. Chin J Cancer Prev Treat (Chinese), 2008, 15: 280–282.

    CAS  Google Scholar 

  9. Tyldesley S, Boyd C, Schulze K, et al. Estimaring the need for radiatherapy for lung cancer: an evidence-basde, epidemiologic approch. Int J Radiat Oncol Biol Phys, 2001, 49: 937–985.

    Article  Google Scholar 

  10. Kong FM, Ten Haken RK, Schipper MJ, et al. High-dose radiation improved local tumor control and overall survival in patients with inoperable/ unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys, 2005, 63: 324–333.

    Article  PubMed  Google Scholar 

  11. Rosenzweig KE, Sim SE, Mychalczak B, et al. Elective nodal irradiation in the treatment of non-small-cell lung cancer with three-dimensional conformal radiation therapy. Int J Radiat Oncol Biol Phys, 2001, 50: 681–685.

    Article  PubMed  CAS  Google Scholar 

  12. Ge W, Yuan GJ, Li CH, et al. CT image fusion in the evaluation of radiation treatment planning for non-small cell lung cancer. Chinese-German J Clin Oncol, 2008, 7: 315–318.

    Article  Google Scholar 

  13. Yin WB, Gu XZ. Radiation therapy oncology (fourth edition). Beijing: China Union Medical University Press, 2008. 578.

  14. Hou YL, Ye M, Wu XD, et al. Three-dimensional conformal radiotherapy in the radical treatment of non-small cell lung cancer. Chin Clin Oncol (Chinese), 2008, 13: 232–234.

    Google Scholar 

  15. Li CH, Ge W, Lin XL, et al. Application of CT/CT image fusion in evaluation of radiotherapy planning for non-small cell lung cancer. Med J Wuhan Univ (Chinese), 2007, 28: 638–641.

    Google Scholar 

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Authors and Affiliations

  1. Center of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China

    Liang Liu, Jinzhong Zhang, Changhu Li, Wei Ge, Shunxiang Luo, Yu Huang & Yongfa Zheng

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  1. Liang Liu
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  2. Jinzhong Zhang
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  3. Changhu Li
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  4. Wei Ge
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  5. Shunxiang Luo
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  6. Yu Huang
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  7. Yongfa Zheng
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Correspondence to Wei Ge.

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Liu, L., Zhang, J., Li, C. et al. Study of the impact of CT/CT image fusion radiotherapy on V20 and radiation pneumonitis of non-small cell lung cancer. Chin. -Ger. J. Clin. Oncol. 11, 72–75 (2012). https://doi.org/10.1007/s10330-011-0896-2

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  • DOI: https://doi.org/10.1007/s10330-011-0896-2

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