Abstract
Molecularly imprinted polymers (MIPs) have been applied as molecular recognition elements to chemical sensors. In this paper, we combined the use of MIPs and electropolymerization to produce a sensor which was capable of detecting dopamine (DA). The MIP electrode was obtained by electrocopolymerization of o-phenylenediamine and resorcinol in the presence of the template molecular DA. The MIP electrode exhibited a much higher current response compared with the non-imprinted electrode. The response of the imprinted sensor to DA was linearly proportional to its concentration over the range 5.0 × 10−7-4.0 × 10−5 M. The detection limit of DA is 0.13 μM (S/N = 3). Moreover, the proposed method could discriminate between DA and its analogs, such as ascorbic acid and uric acid. This method was successfully applied to the determination of DA in dopamine hydrochloride injection and healthy human blood serum. These results revealed that such a sensor fulfilled the selectivity, sensitivity, sped, and simplicity requirements for DA detection and provided possibilities of clinical application in physiological fields.
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Venton BJ, Wightman RM (2003) Anal Chem 75:414a–421a
Luczak T (2008) Electrochim Acta 53:5725–5731
Vasantha VS, Chen SM (2006) J Electroanal Chem 592:77–87
Li QM, Li J, Yang ZJ (2007) Anal Chim Acta 583:147–152
Muzzi C, Bertocci E, Terzuoli L, Porcelli B, Ciari I, Pagani R, Guerranti R (2008) Biomed Pharmacother 62:253–258
Heidbreder CA, Lacroix L, Atkins AR, Organ AJ, Murray S, West A, Shah AJ (2001) J Neurosci Methods 112:135–144
Jo S, Jeong H, Bae SR, Jeon S (2008) Microchem J 88:1–6
Yan W, Feng XM, Chen XJ, Li XH, Zhu JJ (2008) Bioelectrochemistry 72:21–27
Jiao SF, Li MG, Wang C, Chen DL, Fang B (2007) Electrochim Acta 52:5939–5944
Toth B, Pap T, Horvath V, Horvai G (2007) Anal Chim Acta 591:17–21
Shoji R, Takeuchi T, Kubo I (2003) Anal Chem 75:4882–4886
Gupta R, Kumar A (2008) Biotechnol Adv 26:533–547
Holthoff EL, Bright FV (2007) Anal Chim Acta 594:147–161
Xu XL, Zhou GL, Li HX, Liu Q, Zhang S, Kong JL (2009) Talanta 78:26–32
Blanco LMC, Lobo CMJ, Miranda OAJ, Tunon BP (2004) Trac Trends Anal Chem 23:36–48
Kindschy LM, Alocilja EC (2005) Biosens Bioelectron 20:2163–2167
Feng L, Liu Y, Tan Y, Hu J (2004) Biosens Bioelectron 19:1513–1519
Weetall HH, Rogers KR (2004) Talanta 62:329–335
Ulyanova YV, Blackwell AE, Minteer SD (2006) Analyst 131:257–261
Gomez CA, Goicolea MA, Barrio RJ (2005) Analyst 130:1012–1018
Li JP, Zhao J, Wei XP (2009) Sens Actuators B 140:663–669
Rothwell SA, Killoran SJ, Neville EM, Crotty AM, O'Neill RD (2008) Electrochem Commun 10:1078–1081
Kumar SA, Tang CF, Chen SM (2008) Talanta 76:997–1005
Lin XQ, Kang GF, Lu LP (2007) Bioelectrochem 70:235–244
Li NB, Ren W, Luo HQ (2007) Electroanalysis 19:1496–1502
Hu GZ, Zhang DP, Wu WL, Yang ZS (2008) Colloids Surf B 62:199–205
Yu C, Mosbach K (1997) J Org Chem 62:4057–4064
Wang HS, Li TH, Jia WL, Xu HY (2006) Biosens Bioelectron 22:664–669
Chen YY, Lin SY, Yeh YY, Hsiao HH, Wu CY, Chen ST, Wang AHJ (2005) Electrophoresis 26:2117–2127
Chen JH, Zhang J, Lin XH, Wan HY, Zhang SB (2007) Electroanalysis 19:612–615
Thiagarajan S, Chen SM (2007) Talanta 74:212–222
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Song, W., Chen, Y., Xu, J. et al. Dopamine sensor based on molecularly imprinted electrosynthesized polymers. J Solid State Electrochem 14, 1909–1914 (2010). https://doi.org/10.1007/s10008-010-1025-9
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DOI: https://doi.org/10.1007/s10008-010-1025-9