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Tumorvolumenbestimmung

Anforderungen der Strahlentherapie an die moderne radiologische Bildgebung

Tumor volume determination

Demands of radiotherapy on modern radiological imaging

  • Leitthema
  • Published:
Der Onkologe Aims and scope

Zusammenfassung

Hintergrund

Bei der kurativen Strahlentherapie handelt es sich um ein lokales Therapieverfahren, dessen Ziel die Vernichtung aller vitalen Tumorzellen bei gleichzeitig bestmöglicher Schonung des umliegenden Normalgewebes ist. Nur durch die Eradikation aller rezidivfähiger Tumorstammzellen, einer spezifischen Subpopulation innerhalb eines Tumors, kann eine dauerhafte lokale Tumorkontrolle erreicht werden.

Ergebnisse

Für eine präzise Zielvolumenbestimmung sind hochauflösende Bildgebungsmethoden von essenzieller Bedeutung. Nur durch die korrekte Einbeziehung aller Tumoranteile kann eine dauerhafte lokale Tumorkontrolle erzielt werden. Aktuelle Entwicklungen im Bereich des Bio-Imagings eröffnen neue Perspektiven innerhalb der Strahlentherapie durch die Verknüpfung anatomischer Informationen mit zusätzlichen biologischen Eigenschaften des Tumors.

Schlussfolgerung

Der Einsatz dieser modernen Bildgebungsverfahren zur genaueren Festlegung der Bestrahlungsvolumina bildet somit die Grundlage für die Anwendung moderner Bestrahlungstechniken in der Radioonkologie.

Abstract

Background

The aim of radiotherapy as a local treatment method is the eradication of all vital tumor cells in order to achieve permanent local tumor control. From a clinical point of view this means that a patient suffering from cancer can only be cured if all cancer stem cells as a specific subpopulation within a tumor are eliminated by the treatment.

Results

New radiation techniques often employ lower normal tissue doses with less toxicity and/or the possibility to apply higher radiation doses to the target volume. High-resolution imaging is hereby mandatory for precise tumor volume definition as a basis of local tumor control. New developments in the field of bioimaging lead to further perspectives in radiotherapy.

Conclusion

By combining anatomical information with biological characteristics of the tumor, additional benefits for treatment planning and outcome can be achieved. Thus, the use of these modern imaging methods to define irradiation target volumes more clearly forms the basis for the application of modern radiation techniques.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. R. Bütof und M. Krause geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitätsklinikum Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland

    R. Bütof &  M. Krause

  2. OncoRay – Nationales Zentrum für Strahlenforschung in der Onkologie, Medizinische Fakultät und Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Deutschland

    R. Bütof &  M. Krause

  3. Deutsches Konsortium für Translationale Krebsforschung (DKTK), Dresden, Deutschland

    M. Krause

  4. Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland

    M. Krause

  5. Helmholtz-Zentrum Dresden - Rossendorf, Dresden - Rossendorf, Deutschland

    R. Bütof &  M. Krause

Authors
  1. R. Bütof
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  2. M. Krause
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Correspondence to M. Krause.

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Bütof, R., Krause, M. Tumorvolumenbestimmung. Onkologe 21, 382–387 (2015). https://doi.org/10.1007/s00761-014-2813-0

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  • DOI: https://doi.org/10.1007/s00761-014-2813-0

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