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A novel nano-sized bionic function interface for enhancing the ability of red blood cells to carry oxygen

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Abstract

A nano-sized bionic function interface was prepared by immobilizing red blood cells onto a silver electrode, which was modified with cysteamine and colloidal gold. Scanning electron microscopy and electrochemical impedance spectroscopy were used to characterize its surface. Cyclic voltammograms in phosphate buffer solution of pH 7.0 exhibited a pair of redox peaks for oxygen at -378 and -207 mV, respectively. The reduction peak currents at -378 mV were linearly proportional to the oxygen concentration in the range from 12.6 µM to 1.39 mM. Cyclic voltammetry also indicated that the functional surface enhanced the ability of red blood cells to transport oxygen.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (Grant numbers: 20675042; 20875051), the Natural Science Foundation of Jiangsu Province (Grant number: BK2009152).

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Authors and Affiliations

  1. Department of Geographical Science, Institute of Analytical Chemistry for Life Science, School of Public Health, Nantong University, Nantong, 226007, People’s Republic of China

    Yuan-Hong Wang & Jian-Wei Guo

  2. Department of Hygeian Analytical Chemistry, Nantong University, Nantong, 226007, People’s Republic of China

    Hai-Ying Gu

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  1. Yuan-Hong Wang
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  2. Jian-Wei Guo
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Correspondence to Hai-Ying Gu.

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Wang, YH., Guo, JW. & Gu, HY. A novel nano-sized bionic function interface for enhancing the ability of red blood cells to carry oxygen. Microchim Acta 171, 179–186 (2010). https://doi.org/10.1007/s00604-010-0392-3

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  • DOI: https://doi.org/10.1007/s00604-010-0392-3

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