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Methanol sensor based on the combined electrocatalytic oxidative effect of chitosan-immobilized nickel(II) and the antibiotic cefixime on the oxidation of methanol in alkaline medium

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Abstract

A sensor for methanol was fabricated by incorporating the antibiotic cefixime (CEF) along with Ni(II) ion into a chitosan membrane matrix. Sensing is based on the electrocatalytic effect that the complex membrane exerts on the electro-oxidation of methanol. The resulting CEF-Ni(II)/chitosan glassy carbon (GC) electrode had a good electrocatalytic activity to the electro-oxidation of methanol in alkaline medium. The modified electrode had an immense electrocatalytic activity on the second process of methanol oxidation (methanol oxidation intermediate(s) to the final product). The modified electrode had a wide linear range from 20 μM to 12 mM for the determination of methanol in alkaline medium, and a detection limit of 5.24 μM based on a signal-to-noise ratio of 3. In addition, the sensor exhibited good stability.

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Acknowledgements

This work was supported by Specialized Research Fund for the Doctoral Program of Higher Education (no. 20060532006) and National Outstanding Youth Foundation of China (no. 50725825).

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Authors and Affiliations

  1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Hunan, Changsha, 410082, People’s Republic of China

    Yong Liu, Shenglian Luo, Wanzhi Wei, Xiaoying Liu & Xiandong Zeng

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  1. Yong Liu
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  2. Shenglian Luo
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  3. Wanzhi Wei
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  4. Xiaoying Liu
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  5. Xiandong Zeng
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Correspondence to Shenglian Luo.

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Liu, Y., Luo, S., Wei, W. et al. Methanol sensor based on the combined electrocatalytic oxidative effect of chitosan-immobilized nickel(II) and the antibiotic cefixime on the oxidation of methanol in alkaline medium. Microchim Acta 164, 351–355 (2009). https://doi.org/10.1007/s00604-008-0064-8

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  • DOI: https://doi.org/10.1007/s00604-008-0064-8

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