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The predictive compensation path research of the micro tube fabrication process

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Abstract

Inkjet-based organ printing or 3D organ printing can be implemented using orifice-based and orifice-free approaches. Inkjetting, the most widely used orifice-based fabrication approach, has been applied to fabricate various biological constructs, such as alginate tubes. There are two main factors that may lead to failure during the fabrication of the tubular constructs with an overhang using horizontal printing: Structure instability due to the moment imbalance and structure failure due to the droplet impact-induced crash or buckling. This study aims to investigate how to theoretically construct a predicted tube printing path which can compensate for deformation in the printing process. First, we discuss the influence of stress in the printing process, subsequently we proceed to simulate the printing of the tube as a thin curved beam under droplet impact force, and obtain the unchanged shape information from the deformed shape, and then we put forward the predicted-path algorithm of the tube fabrication (PPATF). Second, we verify the method effectiveness and correctness by constructing the predicted path of a tube of 6 mm diameter and using finite element analysis (FEA) to simulate the deformation in the printing process. Lastly, we use the predicted path to print the tube. The cross section of the fabricated constructs can be nearly circular with the predictive compensation path.

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Abbreviations

R:

The initial radius of curvature of the center line of the curved beam at any point m of the center line

ρ:

The radius of curvature of the curved beam after deformation at any point m of the center line

l:

The longitude length of this tube

M:

The moment of at any point m of the center line of the curved beam before deformation

t:

The thickness of the wall

E:

Young’s modulus of the block material

ω:

The radial displacement

B:

The width of beam

h:

The height of beam

E:

The Young’s Model of Printing Material

s 0 :

The initial arc coordinate

\({\text{s}}_{0}^{*}\) :

The deformed arc coordinate

Δ0 :

The deformed rate along the beam

u:

The displacement along X direction

w:

The displacement along Y direction

References

  • Abouna GM (2008) Organ shortage crisis: problems and possible solutions. Transpl Proc 40(1):34–38

    Article  Google Scholar 

  • Bacabac RG, Smit TH, Cowin SC, Van Loon JJ, Nieuwstadt FT, Heethaar R, Klein-Nulend J (2005) Dynamic shear stress in parallel-plate flow chambers. J Biomech 38:159–167

    Article  Google Scholar 

  • Binder KW et al (2011) Drop-on-demand inkjet bioprinting: a primer. Gene Therapy Regul 6(01):33–49

    Article  Google Scholar 

  • Boland T et al (2006) Application of inkjet printing to tissue engineering. Biotechnol J 1(9):910–917

    Article  Google Scholar 

  • Cui X, Boland T (2009) Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials 30(31):6221–6227

    Article  Google Scholar 

  • Duan B et al (2014) Three-dimensional printed trileaflet valve conduits using biological hydrogels and human valve interstitial cells. Acta Biomater 10(5):1836–1846

    Article  Google Scholar 

  • He J et al (2014) Advanced tissue engineering strategies for vascularized parenchymal constructs. J Mech Med Biol 14(1):143001

    Article  Google Scholar 

  • Langer R, Vacanti JP (1993) Tissue engineering. Science 260(5110):920–926

    Article  Google Scholar 

  • Michael C (2014) A review of self-assembled monolayers as potential terahertz frequency tunnel diodes. Nano Res 7(5):589–625

    Article  MathSciNet  Google Scholar 

  • Mironov V et al (2003) printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol 21(4):157–161

    Article  MathSciNet  Google Scholar 

  • Mironov V et al (2009) Organ printing: tissue spheroids as building blocks. Biomaterials 30(12):2164–2174

    Article  MathSciNet  Google Scholar 

  • Norotte C et al (2009) Scaffold-free vascular tissue engineering using bioprinting. Biomaterials 30(30):5910–5917

    Article  Google Scholar 

  • Nakamura M et al (2005) Biocompatible inkjet printing technique for designed seeding of individual living cells. Tissue Eng 11(11/12):1658–1666

    Article  Google Scholar 

  • Quist AP, Pavlovic E, Oscarsson S (2005) Recent advances in microcontact printing. Anal Bioanal Chem 381:591–600

    Article  Google Scholar 

  • Wang JZ, Zheng ZH, Li HW, Huck WT, Sirringhaus H (2004) Dewetting of conducting polymer inkjet droplets on patterned surfaces. Nat Mater 3:171–176

    Article  Google Scholar 

  • Xu C, Chai W, Huang Y, Markwald RR (2012) Scaffold-free inkjet printing of three-dimensional zigzag cellular tubes. Biotechnol Bioeng 109(12):3152–3160

    Article  Google Scholar 

  • Xu C et al (2014) Study of droplet formation process during drop-on-demand inkjetting of living cell-laden bioink. Langmuir 30:9130–9138

    Article  Google Scholar 

  • Yan J, Huang Y, Chrisey DB (2013) Laser-assisted printing of alginate long tubes and annular constructs[J]. Biofabrication 5(1):015–020

    Article  Google Scholar 

Download references

Acknowledgments

The paper was support by the National Natural Science Foundation of China (61100101, 51475129, 51275141, 51305113), the paper was also supported by Key Discipline of The Ocean Techtronic Equipments Technology. The paper was also supported by Nature Science Foundation of Zhejiang Province “MEMS united constraints model order reduction method and solution research (LY14E050026)”. The project also was supported by Zhejiang Province Higher Visiting Scholar project “Model order reduction technology and used in MEMS, FX2014080”.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou, 310018, Zhejiang, China

    Youping Gong, Yunpeng Lv, Shaohui Su, Zhangming Pen & Guojin Chen

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  1. Youping Gong
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  2. Yunpeng Lv
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  3. Shaohui Su
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  4. Zhangming Pen
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  5. Guojin Chen
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Correspondence to Zhangming Pen.

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Gong, Y., Lv, Y., Su, S. et al. The predictive compensation path research of the micro tube fabrication process. Microsyst Technol 22, 2209–2222 (2016). https://doi.org/10.1007/s00542-015-2598-0

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  • DOI: https://doi.org/10.1007/s00542-015-2598-0

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