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Radiation-epidemiological studies of thyroid cancer incidence among children and adolescents in the Bryansk oblast of Russia after the Chernobyl accident (1991–2001 follow-up period)

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Abstract

In this study, thyroid cancer incidence (follow-up period: 1991–2001) has been analyzed, including persons who were exposed as children at an age between 0 and 17 years and who are living in the Bryansk oblast, the worst contaminated area of Russia after the Chernobyl accident. According to the census of 1989, the population of this oblast comprises 375 thousand people. Thyroid doses from incorporated radioiodine isotopes—both for the thyroid cancer cases and the study population—were determined based on the official methodology approved by the Russian Scientific Commission on Radiation Protection. Between 1991 and 2001, a total of 199 thyroid cancer cases were diagnosed at cancer centers (the so-called oncological dispensaries) of the investigated regions. The performed analysis relies on medical and dosimetric information available from the Russian National Medical and Dosimetric Registry which was established after the Chernobyl accident. Diagnoses were confirmed histologically for 95% of the cases. The analysis described revealed statistically significant radiation risk only for those exposed as children at an age of 0–9 years. In this group, the standardized incidence ratio (the national incidence rate was used as a reference) in the considered time period is estimated to be 6.7 (5.1, 8.6 95%CI) and 14.6 (10.3, 20.2 95%CI) for girls and boys, respectively. The risk dependence on age at exposure has also been studied. It has been shown that the smaller the age the higher the risk. For girls whose age at exposure was 0–4 years, the excess relative risk per 1 Gy for the period 1991–2001 was 45.3 (5.2, 9,953 95%CI; with internal control) and 28.8 (4.3, 2,238 95%CI; with external control), respectively. For boys whose age at exposure was 0–9 years the corresponding excess relative risk per 1 Gy was 68.6 (10.0, 4,520 95%CI) and 177.4 (−276, 106 95%CI), respectively. Dependence of radiation risk on time was studied, with the focus on two follow-up periods 1991–1996 and 1997–2001, respectively. In 1997–2001 the radiation risk is shown to decrease among girls, and increase among boys.

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References

  1. Likhtarev IA, Sobolev BG, Kairo IA, Tronko ND, Bogdanova TI, Oleinic VA, Epshtein EV, Beral V (1995) Thyroid cancer in the Ukraine. Nature 375:365

    Article  ADS  Google Scholar 

  2. Jacob P, Gulko G, Heidenreich W, Likhtarev IA, Kairo IA, Tronko ND, Bogdanova TI, Kenigsberg J, Buglova E, Drozdovich V, Golovneva A, Demidchik EP, Balonov M, Zvonova I, Beral V (1998) Thyroid cancer risk to children calculated. Nature 392:31–32

    Article  ADS  Google Scholar 

  3. Thomas G, Karaoglou A, Willliams ED (eds) (1999) Radiation and thyroid cancer. In: Proceeding of an international seminar on radiation and thyroid cancer. World Scientific Publishing, Brussels-Luxembourg

  4. Ivanov VK, Gorski AI, Tsyb AF, Maksioutov MA, Rastopchin EM (1999) Dynamics of thyroid cancer incidence in Russia following the Chernobyl accident. J Radiol Prot 19(4):305–318

    Article  Google Scholar 

  5. Ivanov VK, Gorski AI, Pitkevitch VA, Tsyb AF (1999) Risk of radiogenic thyroid cancer in Russia following the Chernobyl accident. In: Thomas G, Karaoglou A, Willliams ED (eds) Radiation and thyroid cancer. Proceeding of an international seminar on radiation and thyroid cancer. World Scientific Publishing, Brussels-Luxembourg, pp 89–96

  6. Heidenreich WF, Kenigsberg Y, Jacob P, Buglova E, Gulko G, Paretzke HG, Demidchik EP, Golovneva A (1999) Time trends of thyroid cancer incidence in Belarus after Chernobyl accident. Radiat Res 151:617–625

    Article  Google Scholar 

  7. Jacob P, Kenigsberg Y, Zvonova I, Gulko G, Buglova E, Heidenreich WF, Golovneva A, Bratilova A, Drozdovitch V, Kruk J, Pochtennaja G, Balonov M, Demidchik E, Paretzke HG (1999) Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia. Br J Cancer 80(9):1461–1469

    Article  Google Scholar 

  8. Likhtarev IA, Kayro IA, Shpak VM, Tronko ND, Bogdanova TI (1999) Radiation-induced and background thyroid cancer of Ukrainian children (dosimetric approach). Int J Radiat Med 3–4:51–66

    Google Scholar 

  9. Ivanov VK, Gorski AI, Tsyb AF, Maksioutov MA, Vlasov OK, Godko AM (2002) Risk of radiogenic thyroid cancer in the population of the Bryansk and Oryol regions of Russia after the Chernobyl accident (1991–1998). In: Yamashita S, Shubata Y, Hoshi M, Fujimura K (eds) Chernobyl: message for the 21st century. Proceedings of the 6th Chernobyl Sasakava Medical Cooperation symposium. Elsevier, Amsterdam, pp 85–93

  10. Ivanov VK, Gorski AI, Maksioutov MA, Vlasov OK, Godko AM, Tsyb AF, Tirmarche M, Valenty M, Verger P (2003) Thyroid cancer incidence among adolescents and adults in the Bryansk region of Russia following the Chernobyl Accident. Health Phys 84:46–60

    Article  Google Scholar 

  11. Cardis E, Kesminiemi V, Ivanov V, Malakhova I, Shibata I, Khrouch V, Drozdovitch V, Maceika R, Zvonova I, Vlassov O, Bouville A, Goulko G, Hoshi M, Abrosimov A, Anoshko J, Astakhova L, Chekin S, Demidchik E, Galanty R, Ito M, Korobova E, Lushnikov E, Maksioutov M, Masyakin V, Nerovnia A, Parshin V, Parshkov E, Piliptsevich N, Pinchera A, Polyakov S, Shabeka N, Suonio E, Tsyb A, Yamashita S, Williams D (2005) Risk of thyroid cancer after exposure to 131I in childhood. J Natl Cancer Inst 97:724–732

    Article  Google Scholar 

  12. Winkelmann RA, Okeanov A, Gulak L, Remennik L, Rahu M, Storm HH (1998) Cancer registration techniques in the new independent states of the former Soviet Union. In: IARC technical report no. 35. IARC, Lyon, pp 22–43

  13. Reference book of mean thyroid doses in persons of different age resident in the population points of the Bryansk, Tula, Oryol and Kaluga oblasts contaminated after the Chernobyl accident in 1986 (2002) In: Balonov MI, Zvonova IA (eds) Radiation and risk (Bulletin of the National Radiation and Epidemiological Registry) special issue, pp 3–94 (in Russian)

  14. Methodology for reconstruction of thyroid doses from iodine radioisotopes in residents of the Russian Federation exposed to radioactive contamination as a result of the Chernobyl accident in 1986 (2000) Guidelines MU-2.6.1-00b. Russian Ministry of Public Health, Moscow (in Russian)

  15. Zvonova I, Balonov M, Bratilova A, Vlasov A, Pitkevich V, Vlasov O, Shishkanov N (2000) Methodology of thyroid dose reconstruction for population of Russia after the Chernobyl accident. In: Harmonization of radiation, human life and the ecosystem. Proceeding of 10th international congress of the IRPA. International Conference Center Hiroshima, Hiroshima, pp 211–265

  16. Preston DL, Lubin JH, Pierce DA, McConney ME (1993) EPICURE user’s guide. Hirosoft International Corporation, Seatle

    Google Scholar 

  17. Breslow NE, Day NE (1987) Statistical methods in cancer research, vol 2. International Agency for Research on Cancer, Lyon, IARC Scientific publication No. 82, p 96

  18. Thompson DE, Mabuchi K, Ron E, Soda M, Tokunaga M, Oshikubo S, Sugimoto S, Ikeda T, Terasaki M, Izumi S, Preston DL (1994) Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958–1987. Radiat Res 137:S17–S67

    Article  Google Scholar 

  19. Shore RE (1992) Issues and epidemiological evidence regarding radiation-induced thyroid cancer. Radiat Res 131:98–117

    Article  ADS  Google Scholar 

  20. Ron E, Lubin JY, Shore RE, Mabuchi K, Modan B, Pottern LM, Shneider A, Tucker M, Boice JD (1995) Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies. Radiat Res 141:259–277

    Article  Google Scholar 

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Authors and Affiliations

  1. Medical Radiological Research Centre of Russian Academy of Medical Sciences, 4 Korolyov street, 249036, Obninsk, Kaluga region, Russia

    V. K. Ivanov, A. I. Gorski, A. F. Tsyb, M. A. Maksioutov, K. A. Tumanov & O. K. Vlasov

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  1. V. K. Ivanov
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  2. A. I. Gorski
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  3. A. F. Tsyb
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  4. M. A. Maksioutov
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  5. K. A. Tumanov
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  6. O. K. Vlasov
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Correspondence to V. K. Ivanov.

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Ivanov, V.K., Gorski, A.I., Tsyb, A.F. et al. Radiation-epidemiological studies of thyroid cancer incidence among children and adolescents in the Bryansk oblast of Russia after the Chernobyl accident (1991–2001 follow-up period). Radiat Environ Biophys 45, 9–16 (2006). https://doi.org/10.1007/s00411-006-0039-2

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  • DOI: https://doi.org/10.1007/s00411-006-0039-2

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