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Self-assembled nanostructures of a biomimetic glycopolymer–polypeptide triblock copolymer

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Abstract

The self-assembling behavior of a biomimetic glycopolymer–polypeptide triblock copolymer in aqueous solution was described and characterized by employing the hydrophobic dye solubilization method and transmission electron microscopy. The large spherical micelles can be easily generated from the dissolution of triblock copolymer in water. The morphology changes from sphere to lamellae, then to worm-like micelle, can be conveniently transformed by initial copolymer concentration. The multivalent interaction of lectins with lactose-installed polymeric aggregates was preliminarily investigated by UV-Vis spectra. Notably, this kind of aggregates may be useful as artificial polyvalent ligands in the investigation of carbohydrate–protein recognition and for the design of site-specific drug delivery systems.

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References

  1. Discher DE, Eisenberg A (2002) Science 297:967–973

    Article  CAS  Google Scholar 

  2. Bronich TK, Ouyang M, Kabanov VA, Eisenberg A, Szoka FC, Kabanov AV (2002) J Am Chem Soc 124:11872–11873

    Article  CAS  Google Scholar 

  3. Won YY, Davis HT, Bates FS (1999) Science 283:960–963

    Article  CAS  Google Scholar 

  4. Jenekhe SA, Chen XL (1998) Science 279:1903–1907

    Article  CAS  Google Scholar 

  5. Liu S, Armes SP (2002) Angew Chem Int Ed 41:1413–1416

    Article  CAS  Google Scholar 

  6. Liu S, Billingham NC, Armes SP (2001) Angew Chem Int Ed 40:2328–2331

    Article  CAS  Google Scholar 

  7. Butun V, Billingham NC, Armes SP (1998) J Am Chem Soc 120:11818–11819

    Article  Google Scholar 

  8. Zhang L, Yu K, Eisenberg A (1996) Science 272:1777–1779

    Article  CAS  Google Scholar 

  9. Zhang L, Eisenberg A (1996) J Am Chem Soc 118:3168–3181

    Article  CAS  Google Scholar 

  10. Shen H, Zhang L, Eisenberg A (1999) J Am Chem Soc 121:2728–2740

    Article  CAS  Google Scholar 

  11. Yu Y, Eisenberg A (1997) J Am Chem Soc 119:8383–8384

    Article  CAS  Google Scholar 

  12. Luo L, Eisenberg A (2001) J Am Chem Soc 123:1012–1013

    Article  CAS  Google Scholar 

  13. Luo L, Eisenberg A (2002) Angew Chem Int Ed 41:1001–1004

    Article  CAS  Google Scholar 

  14. Chelot F, Lecommandoux S, Gnanou Y, Klok HA (2002) Angew Chem Int Ed 41:1340–1343

    Google Scholar 

  15. Kukula J, Schlaad H, Antonietti M, Forster S (2002) J Am Chem Soc 124:1658–1663

    Article  CAS  Google Scholar 

  16. Cornelissen JLM, Fischer M, Sommerdjk AJM, Nolte RJM (1998) Science 280:1427–1430

    Article  CAS  Google Scholar 

  17. Velonia K, Rowan AE, Nolte RJM (2002) J Am Chem Soc 124:4224–4225

    Article  CAS  Google Scholar 

  18. Boerakker MJ, Hannink JM, Bomans PHH, Frederik DM, Nolte RJM, Meijer EM, Sommerdijk NJM (2002) Angew Chem Int Ed 41:4239–4241

    Article  CAS  Google Scholar 

  19. You LC, Lu FZ, Li ZC, Zhang W, Li FM (2003) Macromolecules 36:1–4

    Article  CAS  Google Scholar 

  20. Thoma G, Katopodis AG, Voelcker N, Duthaler RO, Streiff MB (2002) Angew Chem Int Ed 41:3195–3198

    Article  CAS  Google Scholar 

  21. Rendle PM, Seger A, Rodrigues J, Oldham NJ, Bott RR, Jones JB, Cowan MM, Davis BG (2004) J Am Chem Soc 126:4750–4751

    Article  CAS  Google Scholar 

  22. Roy R (2003) Trends Glycosci Glyc 15:291–310

    CAS  Google Scholar 

  23. Roy R (2001) Dendrimers and other dendritic polymers, chap 15. Wiley, New York, pp 361–382

  24. Davis BG (2002) Chem Rev 102:579–602

    Article  CAS  Google Scholar 

  25. Takasu A, Houjyou T, Inai Y, Hirabayashi T (2002) Biomacromolecules 3:775–782

    Article  CAS  Google Scholar 

  26. Dong CM, Sun XL, Faucher K, Apkarian R, Chaikof EL (2004) Biomacromolecules 5:224–231

    Article  CAS  Google Scholar 

  27. Park SY, Han BR, Na KM, Han DK, Kim SC (2003) Macromolecules 36:4115–4124

    Article  CAS  Google Scholar 

  28. Liang YZ, Li ZC, Li FM (2000) Chem Lett (4):320–321; PS77-b-PGEA6 was a block copolymer with 77 repeating units of styrene and 6 repeating units of 2-(beta-D-glucopyranosyloxy) ethyl acrylate

  29. The characteristic peaks for α-helix and β-sheet structures are at 1,653 and 1,627 cm−1, respectively

  30. Cairo CW, Gestwicki JE, Kanai M, Kiessling LL (2002) J Am Chem Soc 124:1615–1619

    Article  CAS  Google Scholar 

  31. Mammen M, Choi SK, Whitesides GM (1998) Angew Chem Int Ed 37:2754–2794

    Article  Google Scholar 

  32. Sun XL, Faucher KM, Houston M, Grande D, Chaikof EL (2002) J Am Chem Soc 124:7258–7259

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Polymer Science & Engineering, School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Room 314, 800 Dong-Chuan Road, Shanghai, 200240, P. R. China

    Chang-Ming Dong

  2. Department of Surgery, School of Medicine, Emory University, Atlanta, GA, 30322, USA

    Elliot L. Chaikof

Authors
  1. Chang-Ming Dong
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  2. Elliot L. Chaikof
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Correspondence to Chang-Ming Dong.

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Dong, CM., Chaikof, E.L. Self-assembled nanostructures of a biomimetic glycopolymer–polypeptide triblock copolymer. Colloid Polym Sci 283, 1366–1370 (2005). https://doi.org/10.1007/s00396-005-1323-4

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  • DOI: https://doi.org/10.1007/s00396-005-1323-4

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