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In vitro release of protein from poly(butylcyanoacrylate) nanocapsules with an aqueous core

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Abstract

Factors influencing the in vitro release of bovine serum albumin (BSA) from poly(butylcyanoacrylate) (PBCA) nanocapsules, such as the pH value, BSA loading, the polymeric nanocapsule walls and protein molecular weight, were investigated in detail. The BSA release rate was affected by the degradation rate of the polymeric wall and protein loading. For low molecular weight proteins, the initial burst release was faster than that of high molecular weigh proteins and got to equilibrium quickly. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis results showed that BSA encapsulated within PBCA nanocapsules did not suffer covalent aggregation or fragmentation during the initial days of in vitro incubation. For nanocapsules prepared by interfacial polymerization in water-in-oil microemulsions, these findings were useful as a foundation for the development of nanocapsules with desired properties.

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Acknowledgements

This study was sponsored by the “Outstanding Young Scientist Fund of Sichuan Province” and the “Hundreds of Talent Program” of the Chinese Academy of Sciences.

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Authors and Affiliations

  1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, 610041, Chengdu, Sichuan, China

    Sai Li, Yi He, Cao Li & Xiaobo Liu

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  1. Sai Li
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  2. Yi He
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  3. Cao Li
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  4. Xiaobo Liu
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Correspondence to Xiaobo Liu.

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Li, S., He, Y., Li, C. et al. In vitro release of protein from poly(butylcyanoacrylate) nanocapsules with an aqueous core. Colloid Polym Sci 283, 480–485 (2005). https://doi.org/10.1007/s00396-004-1173-5

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  • DOI: https://doi.org/10.1007/s00396-004-1173-5

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