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Study on surfactant coating of polymeric nanoparticles for controlled delivery of anticancer drug

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Abstract

Biodegradable nanoparticles loaded with anticancer drug paclitaxel and appropriately coated with polyvinyl alcohol (PVA), polyethylene glycol (PEG) as well as d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) were produced and characterised by various analysis techniques such as laser light scattering (LLS) for particle size and size distribution, scanning electron microscopy (SEM) and atomic force microscopy (AFM) for particle morphology, X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared-Photoacoustic Spectroscopy (FTIR-PAS) for surface chemistry, and high performance liquid chromatography (HPLC) for drug encapsulation efficiency (EE) and in vitro release kinetics. The emphasis was given to the possible effects of surface coating on the physicochemical and pharmaceutical properties of paclitaxel loaded nanoparticles. It was found that the type and amount of the surfactant could significantly affect the drug EE in the nanoparticles, the particles characteristics and their in vitro release behaviour. The surfactants dominated on the nanoparticles’ surface and the coated nanoparticles displayed in spherical shape with relative smooth surface within the resolution scope of the equipment. The particle size and size distribution showed close relation to the surface coating, which may also be responsible for the drug encapsulation efficiency and the in vitro release kinetics. A favourable formulation of drug loaded nanoparticles of desired properties could be obtained by optimising the fabrication parameters.

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Acknowledgment

The authors acknowledge with thanks the financial support of the Singapore-MIT Alliance (SMA) Programme: Innovation in Manufacturing Systems and Technology (IMST), Nanyang Technological University, Singapore; and the Research Grants R-397–000–001–112 from the Division of Bioengineering, National University of Singapore.

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Authors and Affiliations

  1. Singapore-MIT Alliance (SMA), Nanyang Technological University (NTU), 50 Nanyang Avenue, 639798, Singapore

    Li Mu

  2. Department of Chemical Engineering, National University of Singapore, 10 Kent Ridge Crescent, 119260, Singapore

    Pei-Hsing Seow & Sheu-Ngo Ang

  3. Division of Bioengineering, National University of Singapore (NUS), 9 Engineering Drive 1, 117576, Singapore

    Si-Shen Feng

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  1. Li Mu
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  2. Pei-Hsing Seow
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  3. Sheu-Ngo Ang
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Correspondence to Li Mu.

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Mu, L., Seow, PH., Ang, SN. et al. Study on surfactant coating of polymeric nanoparticles for controlled delivery of anticancer drug. Colloid Polym Sci 283, 58–65 (2004). https://doi.org/10.1007/s00396-004-1090-7

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  • DOI: https://doi.org/10.1007/s00396-004-1090-7

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