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Present and future of surface plasmon resonance biosensors

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Abstract

Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves—surface plasmon-polaritons—to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors.

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Acknowledgement

This work was supported by the Grant Agency of the Czech Republic under contracts 102/03/0633, 303/03/0249, and 203/02/1326.

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  1. Institute of Radio Engineering and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, Prague, Czech Republic

    Jiří Homola

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Homola, J. Present and future of surface plasmon resonance biosensors. Anal Bioanal Chem 377, 528–539 (2003). https://doi.org/10.1007/s00216-003-2101-0

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