Abstract.
Ion mobility spectrometry (IMS) has been used for over 30 years as a sensitive detector of organic compounds. The following is a brief review of IMS and its principles with an emphasis on its usage when coupled to mass spectrometry. Since its inception, IMS has been interfaced with quadrupole, time-of-flight, and Fourier-transform ion cyclotron resonance mass spectrometry. These hybrid instruments have been employed for the analysis of a variety of target analytes, including biomolecules, explosives, chemical warfare degradation products, and illicit drugs.
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Collins, D., Lee, M. Developments in ion mobility spectrometry–mass spectrometry. Anal Bioanal Chem 372, 66–73 (2002). https://doi.org/10.1007/s00216-001-1195-5
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DOI: https://doi.org/10.1007/s00216-001-1195-5