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Poly (ortho esters)

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Biopolymers I

Part of the book series: Advances in Polymer Science ((POLYMER,volume 107))

Abstract

The synthesis and characterization of four distinct families of poly (ortho esters) are described and designated as poly (ortho esters) I, II, III and IV. Poly (ortho ester) I is prepared by the transesterification of diethoxytetrahydrofuran with diols. Poly (ortho ester) II is prepared by the condensation of 3,9-bis (ethylidene 2,4,8,10-tetraoxaspiro [5, 5] undecane) with diols to produce a linear polymer or with a triol to produce a crosslinked polymer. Poly (ortho ester) III is prepared by the condensation of a flexible triol with and alkyl orthoacetate to produce ointment-like materials. Poly (ortho ester) IV is prepared by the condensation of a rigid triol with and alkyl orthoacetate to produce solid materials. The detailed mechanism of hydrolysis of these polymers has been determined and drug release data for a number of therapeutic agents are presented.

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Authors and Affiliations

  1. Controlled Release and Biomedical Polymers Department, SRI International, 94025, Menlo Park, CA, USA

    J. Heller

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  1. J. Heller
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Robert S. Langer Nicholas A. Peppas

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© 1993 Springer-Verlag

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Heller, J. (1993). Poly (ortho esters). In: Langer, R.S., Peppas, N.A. (eds) Biopolymers I. Advances in Polymer Science, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0027551

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  • DOI: https://doi.org/10.1007/BFb0027551

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56148-4

  • Online ISBN: 978-3-540-47478-4

  • eBook Packages: Springer Book Archive

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