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A convenient, rapid and eco-friendly synthesis of isoxazoline heterocyclic moiety containing bridge at 2°-amine as potential pharmacological agent

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Abstract

2-Amino-4-(coumarin-3-yl)-thiazole (1) reacted with acetyl chloride gives compound (2) which on further refluxed with various aromatic aldehydes gives compound (3a-j). Thus obtained (3a-j) on further condensed with NH4OH.HCl using NaOH as a catalyst afforded isoxazoles (4a-j). All the synthesized compounds characterized on the basis of the IR, 1H NMR, 13C NMR and elemental analysis. All the compounds have been screened for antibacterial activity against bacteria (Gram + ve) & (Gram − ve) and antifungal activity.

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References

  1. F. Bigi, Tetrahedron Lett. 42 (2001) 5203.

    CAS  Google Scholar 

  2. A. Handan, A. Oznur, K. Ayse, B. Seher, O. Gulten, Indian. J. Chem. 44B (2005) 585.

    Google Scholar 

  3. A.K. Raviraj, V.K. Manohar, Indian. J. Chem. 44B (2005) 591.

    Google Scholar 

  4. L. Xie, Y. Tukeuchi, L.M. Consetino, K. Lee, J. Med. Chem. 42 (1999) 2662.

    CAS  Google Scholar 

  5. K.K. Srinivas, E. Hager, C. Pehit, N.E. Davidson, S.R. Khan, J. Med. Chem. 46 (2003) 2813.

    Google Scholar 

  6. N.N. Meteeva, R.N. Kode, K.K. Redda, J. Heterocycl. Chem. 39 (2002) 1251.

    Google Scholar 

  7. B.L. Varma, Indian. J. Heterocycl. Chem. 13 (2003) 111.

    Google Scholar 

  8. D.N. Nagar, V.H. Shah, Indian. J. Heterocycl. Chem. 13 (2003) 173.

    CAS  Google Scholar 

  9. N.R. Natale, M.E. Rogers, R.T. Stoples, J. Med. Chem. 42 (1999) 3087.

    CAS  Google Scholar 

  10. M. Kidwai, Chem. Edu. Rev. 15 (2000) 34.

    Google Scholar 

  11. K.P. Srivastava, Res. J. Chem. Environ. 5 (2001) 77.

    CAS  Google Scholar 

  12. R.S. Varma, Green Chem. 1 (1999) 43.

    CAS  Google Scholar 

  13. K.G. Desai, K.R. Desai, Indian J. Chem. 44B (2005) 2093.

    CAS  Google Scholar 

  14. K.G. Desai, K.R. Desai, Molbank, M475 (2005) m.477 file.

  15. S. Rostamizadeh, S. Jafari, Indian. J. Heterocycl. Chem. 10 (2001) 303.

    CAS  Google Scholar 

  16. K.G. Desai, K.R. Desai, J. Iran. Chem. Soc. 3 (2006) 233.

    CAS  Google Scholar 

  17. S.K. Sahu, A. Mishra, R.K. Behera, Indian. J. Heterocycl. Chem. 6 (1996) 91.

    CAS  Google Scholar 

  18. A.W. Bayer, M. Turk, Am. J. Cli. Path. 45 (1966) 493.

    Google Scholar 

  19. K.G. Desai, K.R. Desai, Bioorg. Med. Chem. 8271 (2006) 14.

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, 395007, Surat (West), Gujarat State, India

    J. T. Desai, C. K. Desai & K. R. Desai

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  1. J. T. Desai
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  2. C. K. Desai
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  3. K. R. Desai
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Correspondence to J. T. Desai.

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Desai, J.T., Desai, C.K. & Desai, K.R. A convenient, rapid and eco-friendly synthesis of isoxazoline heterocyclic moiety containing bridge at 2°-amine as potential pharmacological agent. JICS 5, 67–73 (2008). https://doi.org/10.1007/BF03245817

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  • DOI: https://doi.org/10.1007/BF03245817

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