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Synthesis, structure and anti-acetylcholinesterase activity of 12a-O-methyl territrem B

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Abstract

12a-0-methyl territrem B was synthesized from TRB by treatment with dimethyl sulfate in methanolic NaOH. The structure of 12a-0-methyl territrem B was elucidated by uv, ir nmr and mass spectra and it is 2.5 times more potent than TRB in inhibitory activity on electric eel acetylcholinesterase (E. C. 3.1.1.7.) (AChE).

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Authors and Affiliations

  1. Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan ROC

    Peng Fu Chuo & Chen Ping Ho

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  1. Peng Fu Chuo
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  2. Chen Ping Ho
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Chuo, P.F., Ho, C.P. Synthesis, structure and anti-acetylcholinesterase activity of 12a-O-methyl territrem B. Mycotox Res 11, 99–102 (1995). https://doi.org/10.1007/BF03192071

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  • DOI: https://doi.org/10.1007/BF03192071

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