Abstract
Quantitative measurements of regional cerebral blood flow with N-isopropyl-(Iodine 123)p-iodoamphetamine (I-123 IMP) as a microsphere model were performed in forty cases. The regional cerebral blood flow values obtained with I-123 IMP were slightly underestimated compared with those of Xe-133 inhalation methods (y=0.90x–2.1, r=0.85, p< 0.01). After correction by global extraction (87 %) between the artery and internal jugular vein, which was measured in four patients by means of a catheter technique, the underestimation of the values obtained with I-123 IMP was improved (y=1.0x–2.4, r=0.85, p< 0.01). Several problems in the accurate quantitative measurement of regional cerebral blood flow with I-123 IMP are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Winchell HS, Horst WD, Braun L, Oldendorf WH, Hattner R, Parker H: N-isopropyl-(I-123)P iodoamphetamine: Single-pass brain uptake and washout: Binding to brain synaptosomes: and localization in dog and monkey.J Nucl Med 21: 947–952, 1980
Kuhl DE, Barrio JR, Huang S-C, et al: Quantifying local cerebral blood flow by N-isopropyl-p-(I-123)-iodoamphetamine (IMP) tomography.J Nucl Med 23: 196–203, 1982
Matsuda H, Seki H, Sumiya H, et al: Quantitative cerebral blood flow measurements using N-isopropyl-(Iodine 123)p-iodoamphetamine and single photon emission computed tomography with rotating gamma camera.Am J Physiol Imaging 1: 186–194, 1986
Kanno I, Lassen NA: Two methods for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations.J Comput Assist Tomogr 3: 71–76, 1979
Lassen NA, Henriksen L, Holm S: Cerebral blood-flow tomography: Xe-133 compared with isopropyl-amphetamine-iodine 123: concise communication.J Nucl Med 24: 17–21, 1983
Holman BL, Hill TC, Lee RGL, Zimmerman RE, Moore SC, Royal HD: Brain imaging with radio-labeled amines. In: Freeman LM, Weismann HS, eds. Nuclear Medicine Annual. New York, Raven; 1983: 131–165
Creutzig H, Schober O, Gielow P: Cerebral dynamics of N-Isopropyl-(I-123)-iodoamphetamine.J Nucl Med 27: 178–183, 1986
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Takeshita, G., Toyama, H., Nakane, K. et al. Quantitative measurement of regional cerebral blood flow with I-123 IMP SPECT: A correction of the microsphere model by global extraction between artery and internal jugular vein. Ann Nucl Med 5, 145–148 (1991). https://doi.org/10.1007/BF03164629
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03164629