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Bedeutung apoptotischer prozesse für die Strahlentherapie

Significance of apoptosis for radiotherapy — Part II

Teil II

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Zusammenfassung

Apoptose stellt einen aktiven Prozeß des Zelltods dar. Es ist ein Prozeß, der inhibiert und stimuliert werden kann. zum Beispiel durch Strahlen- und Chemotherapie. Diese Erkenntnis läßt 1. bekannte Konzepte (Therapieschemata. Begriffe) nicht nur unter einem anderen Blickwinkel neu erscheinen, sondern führt 2. zur Entwicklung neuer Konzepte mit der Möglichkeit neuer diagnostischer/prognostischer und therapeutischer Ansätze. Grundsätzliche Fragen und Antworten werden im folgenden dargestellt.

Abstract

Apoptosis is known as an active process of cell death forced by radio- and chemotherapy. Therefore, established concepts (terms, therapy schemes) will reflect a picture different from that usually seen, when examined under the apoptotic point of view. Furthermore, the development of new concepts for innovative diagnosis, prognosis and therapy could be accomplished. This is an attempt to reveal actual features of both aspects.

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Literatur

  1. Abend M, Rhein A, Gilbertz K-P, Blakely WF, van Beuningen D. Correlation of micronucleus and apoptosis assays with reproductive cell death. Int J Radiat Biol 1995;67:315–26.

    Article  PubMed  CAS  Google Scholar 

  2. Abend M, van Beuningen D. Regulation of spontaneous apoptosis in HL-60 cells. (in preparation).

  3. Abend M, van Beuningen D. Micronucleation, an incomplete form of apoptosis? Biochem Soc Trans (in press).

  4. Aftabuddin M, Yamadori I, Yoshino T, Kondo E, Akagi T. Correlation between the number of apoptotic cells and expression of the apoptosis-related antigens Fas, Ley and bcl-2 protein in non-Hodgkins lymphomas. Pathol Int 1995;45:422–9.

    Article  PubMed  CAS  Google Scholar 

  5. Aldridge DR, Arends MJ, Radford IR. Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response. Br J Cancer 1995;71:571–7.

    PubMed  CAS  Google Scholar 

  6. Alles A, Alley K, Barrett JC, et al. Apoptosis: a general comment. News 1991;5:2127–8.

    CAS  Google Scholar 

  7. Baxter GD, Collins RJ, Harmon BV, et al. Cell death by apoptosis in acute leukemia. J Pathol 1989;158:123–9.

    Article  PubMed  CAS  Google Scholar 

  8. Baxter GD, Lavin MF. Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines. J Immunol 1992;148:1949–54.

    PubMed  CAS  Google Scholar 

  9. Benito A, Grillot D, Nunez G, Fernandez-Luna JL. Regulation and function of bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells. Am J Pathol 1995;146:481.

    PubMed  CAS  Google Scholar 

  10. Bhatia U, Traganos F, Darzynkiewicz Z. Induction of cell differentiation potentiates apoptosis triggered by prior exposure to DNA-damaging drugs. Cell Growth Different 1995;6:937–44.

    CAS  Google Scholar 

  11. Boe R, Gjertsen BT, Vintermayr OK, Houge G, Lanotte M, Doskeland SO. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp Cell Res 1991;195:237–46.

    Article  PubMed  CAS  Google Scholar 

  12. Camplejohn RS, Perry P, Hodgson SV, et al. A possible screening test for inherited p53-related defects based on the apoptotic response of peripheral blood lymphocytes to DNA damage. Br J Cancer 1995;72:654–62.

    PubMed  CAS  Google Scholar 

  13. Collins RJ, Verschuer LA, Harmon BV, Prentice RL, Pope JH, Kerr JFR. Spontaneous programmed death (apoptosis) of B-chronic lymphocytic leukaemia cells following their culture in vitro. Br J Haematol 1989;71:343–50.

    Article  PubMed  CAS  Google Scholar 

  14. Culotta E, Koshland DE Jr. p53 sweeps through cancer research. Science 1993;262:1958–61.

    Article  PubMed  CAS  Google Scholar 

  15. Darzynkiewicz Z. Apoptosis in antitumor strategies: modulation of cell cycle or differentiation. J Cell Biochem 1995;58:151–9.

    Article  PubMed  CAS  Google Scholar 

  16. Dee S, Haas-Kogan DA, Israel MA. Inactivation of p53 is associated with decreased levels of radiation-induced apoptosis in medulloblastoma cell lines. Cell Death Different 1995;2:267–75.

    CAS  Google Scholar 

  17. Delic J, Magdelenat H, Barbaroux C, et al. In vivo induction of apoptosis in human lymphocytes by therapeutic fractionated total body irradiation. Br J Radiobiol 1995;68:997–1003.

    CAS  Google Scholar 

  18. Dewey WC, Ling CC, Meyn RE. Radiation-induced apoptosis: relevance to radiotherapy. Int J Radiat Oncol Biol Phys 1995;33:781–96.

    PubMed  CAS  Google Scholar 

  19. Fairbairn JJ, Khan MW, Ward KJ, Loveridge BW, Fairbairn DW, O’Neill KL. Induction of apoptotic cell DNA fragmentation in human cells after treatment with hyperthermia. Cancer Lett 1995;89:183–8.

    Article  PubMed  CAS  Google Scholar 

  20. Falkvoll KH. The occurrence of apoptosis, abnormal mitoses, cells dying in mitosis and micronuclei in a human melanoma xenograft exposed to single dose irradiation. Strahlenther Onkol 1990;166:487–92.

    PubMed  CAS  Google Scholar 

  21. Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994;78:539–42.

    Article  PubMed  CAS  Google Scholar 

  22. Ganem G, Lambin P, Socie G, et al. Potential role for low dose limitedfield radiation therapy (2·2 grays) in advanced low-grade non-Hodgkin’s lymphomas. Hematol Oncol 1994;12:1–8.

    Article  PubMed  CAS  Google Scholar 

  23. Gorczyca W, Gong J, Ardelt B, Traganos F, Darzynkiewicz Z. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res 1993;53:3186–92.

    PubMed  CAS  Google Scholar 

  24. Gorczyca W, Tuziak T, Kram A, Melamed MR, Darzynkiewicz Z. Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labeling of fragmented DNA. Cytometry 1994;15:169–75.

    Article  PubMed  CAS  Google Scholar 

  25. Greenspan HC, Aruoma OI. Oxidative stress and apoptosis in HIV infection: a role for plant-derived metabolites with synergistic antioxidant activity. Imunol Today 1994;15:209–13.

    Article  CAS  Google Scholar 

  26. Han I, Ling Y, Khokhar AR, Perez-Soler R. Cell death and DNA fragmentation induced by liposomal platinium(II) complex, L-NDDP in A2780 and A2780/PDD cells. Anticancer Res 1994;14:421–6.

    PubMed  CAS  Google Scholar 

  27. Henriksen R, Wilander E, Öberg K. Expression and prognostic significance of bcl-2 in ovarian tumors. Br J Cancer 1995;72:1324–9.

    PubMed  CAS  Google Scholar 

  28. Higashiyama M, Doi O, Kodama K, Yockouchi H, Tateichi R. High prevalence of bcl-2 oncoprotein expression in small cell lung cancer. Anticancer Res 1995;15:503–5.

    PubMed  CAS  Google Scholar 

  29. Ijiri K, Potten CS. The circadian rhythm for the number and sensitivity of radiation-induced apoptosis in the crypts of mouse small intestine. Int J Radiat Biol 1990;58:165–75.

    Article  PubMed  CAS  Google Scholar 

  30. Inouye M, Tamarus M, Kameyama Y. Effects of cycloheximide and actinomycin D on radiation-induced apoptotic cell death in the developing mouse cerebellum. Int J Radiat Biol 1992;61:669–74.

    Article  PubMed  CAS  Google Scholar 

  31. Kanitakis J, Montazeri A, Ghohestani R, Faure M, Claudy A. bcl-2 oncoprotein expression in benign nevi and malignant melanomas of the skin. Eur J Dermatol 1995;5:501–7.

    Google Scholar 

  32. Kasagi N, Gomyo Y, Shirai H, Tsujitani S, Ito H. Apoptotic cell death in human gastric carcinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. J Cancer Res 1994; 85:939–45.

    CAS  Google Scholar 

  33. Kaufmann SH. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 1989;49:5870–8.

    PubMed  CAS  Google Scholar 

  34. Lee JM, Bernstein A. Apoptosis, cancer and the p53 tumour suppressor gene. Cancer Metast Rev 1995;14:149–61.

    Article  CAS  Google Scholar 

  35. Lennon SV, Martin SJ, Cotter TG. Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli. Cell Prolif 1991;24:203–14.

    Article  PubMed  CAS  Google Scholar 

  36. Levine B, Huang Q, Isaacs JT, Reed JC, Griffin DE, Hardwick JM. Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature 1993;361:739–42.

    Article  PubMed  CAS  Google Scholar 

  37. Levine EL, Davidson SE, Roberts SA, Chadwick CA, Potten CS, West CML. Apoptosis as predictor of response to radiotherapy in cervical carcinoma. Lancet 1994;344:472.

    Article  PubMed  CAS  Google Scholar 

  38. Ling CC, Chen CH, Li WX. Apoptosis induced at different dose rates: implication for the shoulder region of cell survival curves. Radiother Oncol 1994;32:129–36.

    Article  PubMed  CAS  Google Scholar 

  39. Lotem J, Sachs L. Regulation of bcl-2, bcl-xl and bax in the control of apoptosis by hematopoletic cytokines and dexamethasone. Cell Growth Different 1995;6:647–53.

    CAS  Google Scholar 

  40. Lu QL, Elia G, Lucas S, Thomas JA. bcl-2 proto-oncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma. Int J Cancer 1993;53:29–35.

    Article  PubMed  CAS  Google Scholar 

  41. Marx J. Cell death studies yield cancer clues. Science 1993;259:760–1.

    Article  PubMed  CAS  Google Scholar 

  42. Merritt AJ, Potten CS, Watson, AJM, et al. Differential expression o-bcl-2 i in intestinal epithelia. J Cell Sci 1995;108:2261–71.

    PubMed  CAS  Google Scholar 

  43. Meyn RE, Stephens LC, Ang KK, Hunter, et al. Heterogeneity in the development of apoptosis in irradiated murine tumours of different histologies. Int J Radiat Biol 1993;64:583–91.

    Article  PubMed  CAS  Google Scholar 

  44. Meyn RE, Stephens LC, Voehringer DW, Story MD, Mirkovic N, Milas L. Biochemical modulation of radiation-induced apoptosis in murine lymphoma cells. Radiat Res 1993;136:327–34.

    Article  PubMed  CAS  Google Scholar 

  45. Meyn RE, Strasfeld L, Allen C. Testing the role of p53 in the expression of genetic instability and apoptosis in ataxia-telangiectasia. Int J Radiat Biol 1994;66:141–9.

    Article  Google Scholar 

  46. Mori N, Nishikawa R, Okumoto M, et al. Strain difference in the susceptibility of thymocytes to radiation-induced apoptosis: in vitro study. J Radiat Res 1991;32:277–85.

    Article  PubMed  CAS  Google Scholar 

  47. Mori N, Okumoto M, Morimoto J, et al. Genetic analysis of susceptibility to radiation-induced apoptosis of thymocytes in mice. Int J Radiat Biol 1992;62:153–9.

    Article  PubMed  CAS  Google Scholar 

  48. Olsen DR. Calculation of the biological effect of fractionated radio-therapy: the importance of radiation-induced apoptosis. Br J Radiol 1995; 68:1230–6.

    Article  PubMed  CAS  Google Scholar 

  49. Palayoor ST, Macklis RM, Bump EA, Coleman CN. Modulation of radiation-induced apoptosis and G2/M block in murine T-lymphoma cells. Radiat Res 1995;141:235–43.

    Article  PubMed  CAS  Google Scholar 

  50. Potten CS. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metast Rev 1992;11:179–95.

    Article  CAS  Google Scholar 

  51. Saegusa M, Takano Y, Wakabayashi T, Okayasu I. Apoptosis in gastric carcinomas and its association with cell proliferation and differentiation. Jpn J Cancer Res 1995;86:743–8.

    PubMed  CAS  Google Scholar 

  52. Schwartz GK, Haimovitz-Friedman A, Dhupar SK, et al. Potentiation of apoptosis by treatment with the protein kinase c-specific inhibitor safingol in mitomycin c-treated gastric cancer cells. J Nat Cancer Inst 1995; 87:1394.

    Article  PubMed  CAS  Google Scholar 

  53. Stapper NJ, Stuschke M, Sak A, Stüben G. Radiation-induced apoptosis in human sarcoma and glioma cell lines. Int J Cancer 1995;62:58–62.

    Article  PubMed  CAS  Google Scholar 

  54. Staunton MJ, Gaffney EF. Tumor type is a determinant of susceptibility to apoptosis. Am J Clin Pathol 1995;103:300–12.

    PubMed  CAS  Google Scholar 

  55. Stephens LC, Ang KK, Schultheiss TE, Milas L, Meyn RE. Apoptosis in irradiated murine tumors. Radiat Res 1991;127:308–16.

    Article  PubMed  CAS  Google Scholar 

  56. Stephens LC, Hunter NR, Ang KK, Milas L, Meyn RE. Development of apoptosis in irradiated murine tumors as a function of time and dose. Radiat Res 1993;135:75–80.

    Article  PubMed  CAS  Google Scholar 

  57. Wheeler JA, Stephens LC, Tornos C, et al. ASTRO research fellowship: apoptosis as a predictor of tumor response to radiation in stage IB cervical carcinoma. Int J Radiat Oncol Biol Phys 1995;32:1487–93.

    PubMed  CAS  Google Scholar 

  58. Wood AC, Elvin P, Hickman JA. Induction of apoptosis by anti-cancer drugs with disparate modes of action: kinetics of cell death and changes in c-myc expression. Br J Cancer 1995;71:937–41.

    PubMed  CAS  Google Scholar 

  59. Woods CM, Zhu J, McQueney PA, Bollag D, Lazarides E. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Med 1995;1:506–26.

    PubMed  CAS  Google Scholar 

  60. Zhen W, Vaughan ATM. Effect of caffeine on radiation-induced apoptosis in TK6 cells. Radiat Res 1995;141:170–175.

    Article  PubMed  CAS  Google Scholar 

  61. Zinzani PL, Martinelli G, Buzzi M, Farabegoli P, Bendandi M, Tura S. Apoptosis induction with purine analogs on freshly isolated chronic myeloid leukemia cells. Haematologica 1995;80:390–1.

    PubMed  CAS  Google Scholar 

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Teil I dieser Arbeit, der Definition, Morphologie und biochemische Prozesse der Apoptose, klinisch relevante Nachweismethoden sowie Signaltransduktion behandelt, ist in Strahlenther Onkol 1998; 174:156–66 (Nr. 3) erschienen.

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Abend, M., van Beuningen, D. Bedeutung apoptotischer prozesse für die Strahlentherapie. Strahlenther Onkol 174, 212–216 (1998). https://doi.org/10.1007/BF03038529

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