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Studies on the gastric hunger mechanism

II. The inhibitory effect of dextrose solutions

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The American Journal of Digestive Diseases

Summary

1. Evidence is provided confirming previous observations that dextrose solutions (ten, twenty, twenty-five per cent) placed in the stomach inhibit hunger contractions and that the appearance of gastric motility is not always associated with a drop in blood sugar.

2. Gastric motor activity induced by pilocarpine and insulin are also inhibited by introducing dextrose solutions into the stomach.

3. Gastric secretion provoked by histamine, pilocarpine, insulin as well as psychic secretion also is inhibited by dextrose.

4. Further evidence is presented of a genuine dissociation between the secretory and motor activity of the stomach.

5. The clinical application of these results is discussed.

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Authors and Affiliations

  1. Portland, Oregon

    Ira A. Manville M.D., Ph.D. & Walter R. Munroe B.S.

Authors
  1. Ira A. Manville M.D., Ph.D.
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  2. Walter R. Munroe B.S.
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Additional information

From the Department of Physiology and the Department of Medicine, University of Oregon Medical School, Portland, Oregon.

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Manville, I.A., Munroe, W.R. Studies on the gastric hunger mechanism. American Journal of Digestive Diseases and Nutrition 4, 561–573 (1937). https://doi.org/10.1007/BF02999980

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  • DOI: https://doi.org/10.1007/BF02999980

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