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An immunosensor for syphilis

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Abstract

An immuno responsive membrane was prepared by immobilizing Wasserman antigen to acetylcellulose. The antigen-binding membrane was used in developing an immunosensor for determining specifically corresponding antibody in serum. The senor is characterized by electrochemical determination of the antigen-antibody complex formed at the membranesoluti on interface. Experimental data on the applicability of the sensor to serology tests for syphilis are given as well as an outline of a possible mechanism for evaluating the electrical potential difference across the antigen-binding membrane.

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References

  1. Guilbault, G. G. (1972) Biotechnol. Bioeng. Symp. 3, p. 361.

    Google Scholar 

  2. Clark, Jr.,L. C. (1972) Biotechnol. Bioeng. Symp. 3, p. 377.

    Google Scholar 

  3. Gough, D. A., andAndrade, K. E. (1973) Science 180: 380.

    Article  CAS  Google Scholar 

  4. Rechnits, G. A. (1975) Science 190: 234.

    Article  Google Scholar 

  5. Aizawa, M., Karube, I., andSuzuki, S. (1974) Anal. Chim. Acta 69: 431.

    Article  CAS  Google Scholar 

  6. Aizawa, M., andSuzuki, S. (1976) Denki Kagaku 44: 279.

    CAS  Google Scholar 

  7. Satoh, I., Karube, I., andSuzuki, S. (1976) Biotechnol. Bioeng. 18: 269.

    Article  CAS  Google Scholar 

  8. Aizawa, M., Kato, S., andSuzuki, S. (1977) J. Membrane Sci. 2:125.

    Article  CAS  Google Scholar 

  9. Portnoy, J., Garson, W., andSmith, C. A. (1957) U. S. Public Health Reports 72: 761.

    Google Scholar 

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Authors and Affiliations

  1. Research Laboratory of Resources Utilization, Tokyo Institute of Technology Nagatsuta, Midori-ku, Yokohama 227

    Masuo Aizawa & Shuichi Suzuki

  2. Department of Biochemistry, School of Medicine, Fujita Gakuen University, 470-11, Aichi, Japan

    Yoichi Nagamura, Rikio Shinohara & Isao Ishiguro

Authors
  1. Masuo Aizawa
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  2. Shuichi Suzuki
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  3. Yoichi Nagamura
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  4. Rikio Shinohara
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  5. Isao Ishiguro
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Aizawa, M., Suzuki, S., Nagamura, Y. et al. An immunosensor for syphilis. Journal of Solid-Phase Biochemistry 4, 25–31 (1979). https://doi.org/10.1007/BF02991805

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  • DOI: https://doi.org/10.1007/BF02991805

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