Abstract
This paper gives an overview of the biology of monoclonal antibodies in tumor therapy. The complexity of the monoclonal antibody concept is discussed with functional aspects on tumor antigen, antigen binding, Ig isotypes and effector mechanisms involved.
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Currie G A: Eighty years of immunotherapy: A review of immunological methods used for the treatment of human cancer.BrJ Cancer 26, 141 (1972).
Köhler G, Milstein C: Continuous cultures of fused cells secreting antibody of predef'med specificity.Nature 256, 495 (1975).
Janson C H, Tehrani M J, Wigzell H, Mellstedt H: Rational use of biological response modifiers in hematological malignancies - A review of treatment with interferon, cytotoxic cells and antibodies.Leuk Res 13, 1039 (1989).
Janson C H, TehraniM J, Mellstedt H, Wigzell H: Anti-idiotypic monoclonal antibody to a T-cell chronic lymphatic leukemia. Characterization of the antibody,in vitro effector functions and results of therapy.Cancer lmmunol lmmunother 28, 225 (1989).
Klaus G G B, Pepys M B. Kitajima K, Askonas B A: Activation of mouse complement by different classes of mouse antibody.Immunology 38, 687 (1979).
Denkers E Y, Badger C C, Ladbetter J A, Bernstein I D: Influence of antibody isotype on passive serotherapy of lymphoma.Jlmmuno1 135, 2183 (1985).
McConkey D J, Orrenius S, Jondal M: Cellular signalling in programmed cell death (apoptosis).lmmunol Today 11, 120 (1990).
Goodman G E, Hellström L Brodzinsky L, Nicaise C, Kulander B, Hummel D, HeUström K E: Phase I trial of murine monoclonal antibody L6 in breast, colon, ovarian and lung cancer.J Clin Oncol 8, 1083 (1990).
Lowder J, Meeker T, Campbell M, Garcia C F, Gralow L Miller R A, Warnke R, Levy R: Studies on B lymphoid tumors treated with monoclonal anti-idiotype antibodies: Correlation with clinical responses.Blood 69, 199 (1987).
Jerne N K; Towards a network theory of the immune system.Ann Immunol 125c, 373 (1974).
Lanzavecchia A, Abrignani S, Scheidegger D, Obrist R, Dörken B, Moldenhauer G: Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets.J Exp Med 167, 345 (1988).
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Janson, C.H. Biology of monoclonal antibodies in tumor therapy. Med Oncol. & Tumor Pharmacother. 10, 21–23 (1993). https://doi.org/10.1007/BF02987764
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DOI: https://doi.org/10.1007/BF02987764