Abstract
The present investigation deals with the synthesis of some new salicylamidoacetyl sulfonamides3a,b, salicylamido ethylacetate4, salicylamido acetic acid hydrazide5, which is considered as the key intermediate for the synthesis of several series of new compounds such as salicylamido pyrazol 6 and pyrazolone 7.N-imido-derivatives9, 10, 11, thiadiazole13, oxadiazole14, 15, Schiffs bases16a-f. Cyclocondensation of Schiffs bases with thioglycolic acid gave thiazolidinone18a-c while with acetylchloride afforded azitidinones19a-c and with acetic anhydride gave 1,4-benzoxazepine-3,5-dione. Some of the compounds were tested for their analgesic and antiinflammatory activities as well as ulcerogenic effects. Some derivatives were more effective than salicylamide and ulcerogenic activity was variably lowered.
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Fahmy, H.H., El-Eraky, W. Synthesis and evaluation of the analgesic and antiinflammatory activities ofO-Substituted salicylamides. Arch Pharm Res 24, 171–179 (2001). https://doi.org/10.1007/BF02978252
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DOI: https://doi.org/10.1007/BF02978252