Abstract
The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesized trichothecenes against human solid tumor cell lines. Among them, trichothecin (I) and 4-β-Acetoxy-12,13-epoxytrichothec-9-ene (trichodermin, II) exhibited highly cytotoxic activities. 4-β-Hydroxy-12,13-epoxytrichothec-9-ene (trichodermol, III) and 4-β-Methoxy-12,13-epoxytrichothec-9-ene and 4-α-Hydroxy-12,13-epoxytrichothec-9-ene(VI) had no cytotoxicities up to 10 μg/ml. And in the tested cell lines, HCT15 colon cancer cell line was the most sensitive to all tested trichothecenes.
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Choi, S.U., Choi, E.J., Kim, K.H. et al. Cytotoxicity of trichothecenes to human solid tumor cellsin vitro . Arch. Pharm. Res. 19, 6–11 (1996). https://doi.org/10.1007/BF02976812
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DOI: https://doi.org/10.1007/BF02976812