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Topoisomerase i inhibitors from theStreptomyces sp. strain KM86-9B isolated from a marine sponge

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Abstract

The crude extract ofStreptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.

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Author notes

  1. Junghyun Lim

    Present address: Department of Horticulture Science, Kon-Kuk University, 143-701, Seoul, Korea

Authors and Affiliations

  1. Microbiology Lab., Korea Ocean Research & Development Institute, 425-600, Ansan, Korea

    Hong Kum Lee, Deuk-Soo Lee & Junghyun Lim

  2. College of Pharmacy, Pusan National University, 609-735, Pusan, Korea

    Jung Sun Kim, Kwang Sik Im & Jee H. Jung

Authors
  1. Hong Kum Lee
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  2. Deuk-Soo Lee
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  3. Junghyun Lim
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  4. Jung Sun Kim
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  5. Kwang Sik Im
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  6. Jee H. Jung
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Lee, H.K., Lee, DS., Lim, J. et al. Topoisomerase i inhibitors from theStreptomyces sp. strain KM86-9B isolated from a marine sponge. Arch. Pharm. Res. 21, 729–733 (1998). https://doi.org/10.1007/BF02976766

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  • DOI: https://doi.org/10.1007/BF02976766

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