Abstract
One new stillbene glucoside (6), along with five known compounds (1–5), were isolated from the roots ofPolygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound3 showed DNA topoisomerase I and II inhibitory activities.
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Chang, I. M., Yun, H. S., and Yamasaki, K., β-Sitosterol and β-sitosteryl-3-O-β-D-glucopyranoside isolated fromPlantago asiatica seed.Korean J. Pharmcogn., 12, 12–24 (1981).
Chen, Y., Wang, M. F., Rosen, R. T., and Ho, C. T., 2,2-Diphenyl-1-picrylhydrazyl radical-scavenging active components fromPolygonum multiflorum Thunb.,J. Agric. Food Chem., 47, 2226–2228 (1999).
Fukuda, M., Nishio, K., Kanzawa, F., Ogasawara, H., Ishida, T., Arioka, H., Bojamowski, K., Oka, M., and Saijo, N., Synergism between cisplatin and topoisomerase I inhibitors, NB-506 and SN-38, in human small cell lung cancer cells.Cancer Res., 56, 789–793 (1996).
Crublet, M. L., Long, C., Sevenet, T., Hadi, H. A., and Lavaud, C., Acylated flavonol glycosides from leaves ofPlanchonia grandis.Phytochemistry, 64, 589–594 (2003).
Do, J. C., Son, K. H., and Kang, S. S., Studies on the constituents of the root ofRubus parvifolius (I). Isolation of (−)-epicatechin.Kor. J. Pharmacogn., 19, 170–173 (1988).
Goncalves M. L. S. and Mors, W. B., Vismiaquinone, a β1-isopentenyl substituted anthraquinone fromVismia reichardtiana, Phytochemistry, 20, 1947–1950 (1981).
Kiem, P. V., Cai, X. F., Minh, C. V., Lee, J. J., and Kim, Y. H., Lupane-triterpene carboxylic acids from the leaves ofAcanthopanax trifoliatus.Chem. Pharm. Bull., 51, 1432–1435 (2003).
Kim, D. K., Lim, J. P., Kim, J. W., Park, H. W., and Eun J. S., Antitumor and anti-inflammatory constituents fromCeltis sinensis.Arch. Pharm. Res., 28, 39–43 (2005).
Kitanaka, S. and Takido, M., Dimeric hydroanthracenes from the unripe seeds ofCassia torosa., Phytochemistry, 21(8), 2103–2106 (1982).
Li, G., Lee, C. S., Woo, M. H., Lee, S. H., Chang, H. W., and Son, J. K., Lignans from the bark ofMachilus thunbergii and their DNA topoisomerases I and II inhibition and cytotoxicity.Biol. Pharm. Bull., 27, 1147–1150 (2004).
Lin, L. C., Nalawade, S. M., Mulabagal, V., Yeh, M. S., and Tsay, H. S., Micropropagation ofPolygonum multiflorum Thunb and quantitative analysis of the anthraquinones emodin and physcion formed inin vitro propagated shoots and plants.Biol. Pharm. Bull., 26, 1467–1471 (2003).
Nonaka, G. I., Miwa, N., and Nishioka, I., Stilbene glycoside gallates and proanthocyanidins fromPolygonum multiflorum, Phytochemistry, 21, 429–432 (1982).
Park, S. W., Yook, C. S., and Lee, H. K., Chemical components from the fruits ofCrataegus pinnatifida var. psilosa.Kor. J. Pharmacogn., 25, 328–335 (1994).
Qin, H. L., Zhao, T. Z., Yuan, W. M., Shang, Y. J., Zhao, W., and Zhang, J. X., Assignments of the1H-NMR finger-prints of the roots ofPolygonum cuspidatum, Polygonum multiflorum, Rheum palmatum andRheum tanguticum.Acta Pharmaceutica Sinica, 34, 828–834 (1999).
Rubinstein, L. V., Shoemaker, R. H., Paul, K. D., Simon, R. M., Tosini, S., Skehan, P., Scudiero, D. A., Monks, A., and Boyd, M. R., Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.J. Nat. Cancer Inst., 82, 1113–1118 (1990).
Ryu, G., Ju, J. H., Park, J. Ju., Ryu, S. Y., Choi, B. W., and Lee, B. H., Radical scavenging effects of stilbene glucosides fromPolygonum multiflorum.Arch Pharm Res, 25, 636–639 (2002).
Takeshi, K. and Yutaka M., Anthraquinone compounds inRumex acetosa L..Shoyakugaku Zasshi, 41, 67–74 (1987).
Xiao, P. G., Xing, S. T., and Wang, L. W., Immunological aspects of Chinese medicinal plants as anti-aging drugs.J. Ethnopharmacol., 38, 167–175 (1993).
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Xu, ML., Zheng, M.S., Lee, YK. et al. A new stilbene glucoside from the roots ofPolygonum multiflorum Thunb.. Arch Pharm Res 29, 946–951 (2006). https://doi.org/10.1007/BF02969276
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DOI: https://doi.org/10.1007/BF02969276