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Pectin microspheres for oral colon delivery: Preparation using spray drying method andin vitro release of indomethacin

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Abstract

Drug delivery systems that are based on pectin have been studied for colon specific delivery using the specific activity of colon microflora. The aim of this study was to design a novel method of manufacturing pectin microspheres without oils and surfactants and to investigate the potential use of the pectin microsphere as an oral colon-specific drug carrier. The pectin microspheres were successfully formed using the spray drying method and crosslinking with calcium chloride. From the crosslinked pectin microspheres, indomethancin (IND) release was more supressed than its release from non-crosslinked microspheres. In a low pH (pH 1.4) environment, the pectin microspheres released IND at an amount of about 18±2% of the total loaded weight for 24h while the release rate of IND was stimulated at neutral pH (pH 7.4). IND release from the pectin microspheres was increased by the addition of pectinase. The results clearly demonstrate that the pectin microspheres that were prepared by the spray drying and crosslinking methods are potential carriers for colon-specific drug deliveries.

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Authors and Affiliations

  1. Interdisciplinary Program of Biomedical Engineering, Chonnam National University, 500-757, Gwangju, Korea

    Chang-Moon Lee

  2. Department of Health and Hygiene, Gwang-Yang Health College, 545-703, Jeonnam, Korea

    Dong-Woon Kim

  3. Department of Microbiology, Chonnam National University Medical School, 501-190, Gwangju, Korea

    Hyun-Chul Lee

  4. Faculty of Applied Chemical Engineering and The Research Institute for Catalysis, Chonnam National University, 500-757, Gwangju, Korea

    Ki-Young Lee

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  1. Chang-Moon Lee
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  2. Dong-Woon Kim
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  3. Hyun-Chul Lee
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  4. Ki-Young Lee
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Correspondence to Ki-Young Lee.

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Lee, CM., Kim, DW., Lee, HC. et al. Pectin microspheres for oral colon delivery: Preparation using spray drying method andin vitro release of indomethacin. Biotechnol. Bioprocess Eng. 9, 191–195 (2004). https://doi.org/10.1007/BF02942291

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  • DOI: https://doi.org/10.1007/BF02942291

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