Abstract
Lipid emulsions with saturated triacylglycerols (TAGs) with 4 to 10 carbons in each acyl chain were prepared to study how the oil component alters the stability of the lipid emulsions when phosphatidylcholines were used as emulsifiers. The average droplet size of the emulsions became smaller as the chain length of the TAG increased. For a given oil, emulsion with smaller droplets was formed with an emulsifier having higher HLB value. The influence of HLB values on the droplet size was biggest for the tributyrin (C4) emulsions. For the tricaprylin (C8) emulsions, droplet size was identical at given emulsifier concentrations regardless of HLB values. The HLB value and the concentration of the emulsifiers also affect the droplet size of the emulsions. The emulsions with smaller average droplet size were more stable than with bigger size for 20 days. The oil and water (o/w) interfacial tension is inversely proportional to the initial droplet size of the emulsion.
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References
Tanford, C. (1980)The Hydrophobic Effect. 2nd ed., John Wiley, New York, USA.
Tardos, T. F. and B. Vincent (1983) Emulsion stability. pp. 129–285. P. Becher (ed.).Encyclopedia of emulsion technology, Volume 1 Basic Theory. Marcel Dekker, Inc., New York, USA.
Jumaa, M. and B. W. Müller (1998) The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions.Inter. J. Pharm. 163: 81–89.
Jumaa, M., P. Kleinebudde, and B. W. Müller (1998) Mixture experiments with the oil phase of parenteral emulsions.Eur. J, Pharm. Biopharm. 46: 161–167.
Ekman, S., A. Derksen, and D. M. Small (1988) The partitioning of fatty acid and cholesterol between core and surfaces of phosphatidylcholine-triolein emulsions at pH 7.4.Biochim. Biophys. Acta 959: 343–348.
Ishii, F., I. Sasaki, and H. Ogata (1990) Effect of phospholipid emulsifiers on physicochemical properties of intravenous fat emulsions and/or drug carrier emulsions.J. Pharm. Pharmacol. 42: 513–515.
Sjöstrom, B., B. Bergenståhl, and B. J. Kronberg (1993) A method for the preparation of submicron particles of sparingly water-soluble drugs by precipitation in oil-in-water emulsions: II. Influence of the emulsifier, the solvent, and the drug substance.Pharm. Sci. 82: 584–589.
Chung, H., T. W. Kim, M. Kwon, I. C. Kwon, and S. Y. Jeong (2001) Oil components modulate physical characteristics and function of the natural oil emulsions as drug or gene delivery system.J. Cont. Rel. 71: 339–350.
Girifalco, L. A. and R. J. Good (1957) A theory for the estimation of surface and interfacial energies: Part I. Derivation and application to interface tension.J. Phys. Chem. 61: 904–909.
Yamaguchi, T., K. Nishizaki, S. Itai, H. Hayashi, and H. Ohshima (1995) Physicochemical characterization of parenteral lipid emulsion: Influence of cosurfactants on flocculation and coalescence.Pharm. Res. 12:1273–1278.
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Chung, H., Kim, T.W., Kwon, I.C. et al. Stability of the oil-in-water type triacylglycerol emulsions. Biotechnol. Bioprocess Eng. 6, 284–288 (2001). https://doi.org/10.1007/BF02931991
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DOI: https://doi.org/10.1007/BF02931991