Skip to main content
Log in

Regeneration in autologous and allogenic nerve grafts in the rat with MHC-disparity with and without cyclosporin a: A preliminary report

  • Originals
  • Published:
European Journal of Plastic Surgery Aims and scope Submit manuscript

Summary

The experimental studies show different stages of regeneration and degeneration in autologous and allogenic nerve grafts in 187 rats with and without immunosuppression with Cyclosporin A. Allografts were used in related rats only differing in the major histocompatibility complex (MHC) with the same non-MHC background.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Berger A, Millesi H (1980) Die chirurgische Therapie des Plexus brachialis. Bericht über die 6. Murnauer Unfalltagung der Landesverbände der gewerblichen Berufsgenossenschaften am 14. Juni 1980

  2. Berger A, Meissl G, Millesi H, Pizza H (1975) Verletzungen des Plexus brachialis (Konzpet einer integierten Therapie). Kongreßbericht, Int Congr Notfallchir, Zürich, pp 382–392

  3. Butcher StW, Howard JC (1986) The MHC of the laboratory rat, rattus norwegicus. In: Weir, Machang (eds) Handbook of experimental immunology, 4th edn, vol 3. Blackwell, pp 101.1–101.18

  4. Dhirandra NM, Saad AN, Kunz HW, Gill III TJ (1982) Identification of two class I antigens coded by the major histocompatibility complex of the rat by using monoclonal antibodies. J Immunol 128:1651–1658

    Google Scholar 

  5. Gallico GG (1975) The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts. J Exp Med 149:244

    Article  Google Scholar 

  6. Gill III TJ, Kunz HW, Dhirendra NM and Cortese Hassett AL (1987) The major histocompatibility complex of the rat. Transplantation, 43:773–785.

    PubMed  CAS  Google Scholar 

  7. Günther E, Wurst W, Wonigeit K, Epplen JT (1985) Analysis of the rat major histocompatibility system by southern blot hybridization. J Immunol 134:1257–1261

    PubMed  Google Scholar 

  8. Günther E, Stark O, Koch C (1978) Genetic definition of I region-determined antigens of the rat major histocompatibility complex. Eur J Immunol 8:206–212

    Article  PubMed  Google Scholar 

  9. Günther E, Stark O. The major histocompatibility system of the rat (AG-B or H1-system). In: Götze (ed) The organisation of the major histocompatibility system in animals. pp 207–253

  10. Grochowicz P, Romaniuk A, Jedrzejewska A, Olszewski WL (1987) Rejection pattern of nerve allografts—changes in graft and host cell determinants. Transplantat Proc XIX:1131–1132

    Google Scholar 

  11. Hedrich HJ, Wonigeit K, Günther E (1983) Description of a new RT1 (variant and mapping of the variant gene to the RT1C region. Transplantat Proc XV:1562–1564

    Google Scholar 

  12. Kohoutovå M, Stark O, Kormuth E, Günther E (1981) The recombinant RT1 haplotype of the LEW.1WR2 rat strain. Transplant Proc XIII:1322–1325

    Google Scholar 

  13. Kunz HW, Gill III TJ, Dhirendra NM (1982) The identification and mapping of a second class I locus in the major histocompatibility complex of the rat. J Immunol 128:402–408

    PubMed  CAS  Google Scholar 

  14. Marshak A, Doherty PC, Wilson (1977) DB The control of specificity of cytotoxic T lymphocytes by the MHC (AG-B) in rats and identification of a new alloantigen system showing no AG-B registration. J Exp Med 146:1773–1790

    Article  PubMed  CAS  Google Scholar 

  15. Mackinnon SE, Hudson AR, Falk RE, Hunter DA (1985) The nerve allograft response—an experimental model in the rat. Ann Plast Surg 14:334–339

    Article  PubMed  CAS  Google Scholar 

  16. Millesi H, Berger A, Meissl G (1972) Experimentelle Untersuchung zur Heilung durchtrennter peripherer Nerven. Chir Plastica 1:174–206

    Article  Google Scholar 

  17. Mizumoto S, Tamai S, Goshima J, Yajima H, Yoshi T, Fukui A, Masuhara K (1986) Experimental study of vascularized tibiofibula graft in inbred rats: a preliminary report. J Reconstr Microsurg 3:1–9

    PubMed  CAS  Google Scholar 

  18. Pollard JD, Fitzpatrick L (1973) An ultrastructural comparison of peripheral nerve allografts and autografts. Acta Neuropathol 23:166–180

    Article  PubMed  CAS  Google Scholar 

  19. Ryffel B. Experimental toxicological studies with cyclosporin A. Toxicology Department 881, Preclinical Research. Sandoz, Basle, Switzerland

  20. Singh R, Vriesendorp HM, Mechelse K, Stefanko S (1977) Nerve allografts and histocompatibility in dogs. J Neurosurg 47:737–743

    PubMed  CAS  Google Scholar 

  21. Steiniger B, Klempnauer J, Wonigeit K (1985) Altered distribution of class I and class II MHC antigens during acute pancreas allograft rejection in the rat. Transplantation 40:234–239

    Article  PubMed  CAS  Google Scholar 

  22. Sullivan BA, Hak LJ, Finn WF (1985) Cyclosporine nephrotoxicity: studies in laboratory animals. Transplant Proc XVII:145–159

    Google Scholar 

  23. Stock W, Günther E (1982) Serologic and cellular characterization of products of a new major histocompatibility gene region, RT1.C, of the rat; possible homology to mouse H-2 Qa. J Immunol 128:1923–1928

    PubMed  CAS  Google Scholar 

  24. Wonigeit K, Hedrich HJ, Günther E (1979) Serologic and histogenetic analysis of apparently identical RT1 haplotypes. Transplant Proc XI:1584–1587

    Google Scholar 

  25. Wonigeit K, Schwinzer R, Inomata T, Kunz HW, Gill III TJ (1987) Reactivity of a nonoclonal antibody directed against RT1.E with recombinants defining the RT1C region. Transplant Proc XIX:3006–3007

    Google Scholar 

  26. Wonigeit K (1981) Transplantationsimmunologie. In: Pichlmayr R (ed) Allgemeine und spezielle Operationslehre, Transplantationschirurgie. Springer, Heidelberg, pp 29–121

    Google Scholar 

  27. Whiting PH, Thomson AW, Simpson JG (1985) Cyclosporine: toxicity, metabolism, and drug interactions—implications from animal studies. Transplantat Proc XVII:134–143

    Google Scholar 

  28. Zalewski AA, Silvers WK, Gulati AK Failure of host axons to regenerate through a once successful but later rejected long nerve allograft. J Comp Neurol 209: 347–351

  29. Zalewski AA, Gulati AK (1982) Evaluation of histocompatibility as a factor in the repair of nerve with a frozen nerve allograft. J Neurosurg 56:550–554

    PubMed  CAS  Google Scholar 

  30. Zalewski AA, Gulati AK, Silvers WK (1981) Loss of host axons in nerve allografts after abolishing immunological tolerance in rats. Exp Neurol 72:502–506

    Article  PubMed  CAS  Google Scholar 

  31. Zalewski AA, Silvers WK (1980) An evaluation of nerve repair with nerve allografts in normal and immunologically tolerant rats. J Neurosurg 52:557–563

    Article  PubMed  CAS  Google Scholar 

  32. Zalewski AA, Gulati AK (1980) Survival of nerve and Schwann cells in allografts after cyclosporin A treatment. Exp Neurol 70:219–225

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schaller, E., Becker, M., Mailänder, P. et al. Regeneration in autologous and allogenic nerve grafts in the rat with MHC-disparity with and without cyclosporin a: A preliminary report. Eur. J. Plast. Surg. 12, 261–268 (1989). https://doi.org/10.1007/BF02892722

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02892722

Key words

Navigation