Conclusion
The hard terrain of pancreatic diagnosis has been traversed. Looking back, we can see certain definite landmarks:
-
(1)
The examination of the stool.
-
(2)
Serial serum enzyme levels.
-
(3)
Stimulated serum enzyme levels.
-
(4)
Blood sugar levels.
All these tests are easily done. Duodenal drainage, which has been discussed, may be helpful, may be confirmatory, but is probably not worth the effort; the presence of blood in the aspirate may localize disease. Papanicalaou studies of the duodenal aspirate are valuable, but unfortunately the necessary technical assistance is not universally available.
The ultimate in pancreatic diagnosis has not been described, nor yet have the most complete pancreatic diagnostic tests necessarily been covered. However, from the vantage point of the practicing medical officer, the simplest and the most practical tests for everyday diagnostic use have been amplified.
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References
Andersen, D. H.: Celiac syndrome. I. Determination of fat in feees; reliability of two chemical methods and of microscopic estimate; excretion of feces and of fecal fat in normal children. Am. J. Dis. Child. 69:141–151, Mar. 1945.
Arkin, A., and Weisberg, S. W.: Carcinoma of pancreas, clinical and pathological study of 75 cases. Gastroenterology 13: 118–126, Aug. 1949.
Babkin, B. P.: Secretory mechanisms of the digestive glands. Paul B. Hoeber, Inc., New York, N. Y., 1950.
Bauman L.: The Diagnosis of Pancreatic Diseases. J. B. Lippincott Co., Philadelphia, Pa., 1949.
Berk, J. E.: Diagnosis of carcinoma of the pancreas, Arch. Int. Med. 68:525–559, Sept., 1941.
Bockus, Henry L.: Gastroenterology, Vol. Ill—W. B. Saunders, Philadelphia, Pa., 1946.
Burke, J. O., Plummer, K., and Bradford, S.: Serum amylase response to morphine, mecholyl and secretin as a test of pancreatic function. Gastroenterology 15:699–707, Aug., 1950.
Dashiell, G. F., and Palmer, W. L.: Carcinoma of the pancreas, Arch. Int. Med. 81:173–183, Feb., 1948.
Dornberger, G. R., Comfort, M. W., Wollaeger, E. E., and Power, M. H.: Total fecal solids, fat and nitrogen; study of patients with chronic relapsing pancreatitis. Gastroenterology 11:691–700, Nov., 1948.
Dreiling, D. A., and Hollander, F.: Studies in pancreatic function; preliminary series of clinical studies with secretin test. Gastroenterology 11: 714–729, Nov., 1948.
Fowweather, F. S.: Determination of amount and composition of fat of faeces; composition of fat of faeces of normal adult as ascertained by “wet” method, together with some results in pathological conditions. Brit. J. Exper. Path. 7:15–21, Feb., 1946. (Quoted by Sunderman.)
Frazer, A. C.: Fat metabolism and sprue syndrome. Brit. M. J. 2:769–773, Oct. 8, 1949.
Friedman, M. H. F., and Snape, W. J.: Dissociation of secretion of pancreatic enzymes and bicarbonate in patients with chronic pancreatitis. Gastroenterology 15: 296–303, June 1950.
Grossman, M. I. and Ivy, A. C.: Effect of alloxan upon external secretion of the pancreas, Proc. Soc. Exper. Biol. & Med., 63:62–63, Oct., 1946.
Ingelfinger, F. J.: Medical progress; diagnosis of cancer of pancreas. New England J. Med. 235:653–661, Oct. 31, 1946.
Keith, L. M., Jr., Zollinger, E. M., and McCleery, R. S.: Peritoneal fluid amylase determinations as aids in diagnosis of acute pancreatitis. Arch. Surg. 61:930–936, Nov., 1950.
Lagerlof, H. O.: Pancreatic Function and Pancreatic Disease Studied by Means of Secretin. The Macmillan Co., New York, N. Y.) 1942.
Lake, M.: Diagnostic value of the secretin test, including a report of 19 operated or autopsied cases with anatomical studies of the pancreas. Am. J. Med. 3:18–30, July, 1950.
Lopusniak, M. S., and Bockus, H. L.: Symposium on pancreatic disease; study of pancreatic serum enzymes following secretin injection of pancreatic affections. Gastroenterology 16:294–308, Oct., 1950.
Marble, A. N.: The treatment of diabetes mellitus, Joslin. E. P. et al. Lea & Febiger, Philadelphia, Pa., 1946.
Muether, R. O., and Knight, W. A.: Chronic recurrent pancreatitis. I. Clinical and laboratory aspects. Gastroenterology 12:294–308, Oct., 1950.
Myhre, P., Nesbitt, S., and Hurly, J. T.: Response of serum amylase and lipase to pancreatic stimulation as a test of pancreatic function. Gastroenterology 13:127–134, Aug., 1949.
Peters, J. P. and VanSlvke, D. D.: Quantitative Clinical Chemistry. Williams Wilkins Co., Baltimore, Md., 1946.
Popper, H. L., and Necheles, H.: New test for pancreatic function; experimental observations. Gastroenterology 1:490–499, May, 1943.
Pratt, J. H.: Pancreatic disease. P. A. M. A. 120:175–182, Sept. 19, 1942.
Pratt, J. H.: Diagnosis of pancreatic disease. New York State J. Med. 43:1847–1855, Oct. 1, 1943.
Reinhoff, W. F., and Pickrell, K. L.: Pancreatitis; an anatomic study of the pancreatic and extrahepatic biliary systems. Arch. Surg. 51:205–219, Nov.-Dec., 1945.
Ryan, J. D., Doubilet, H., and Mulholland, J. H.: Observations on biliary-pancreatic dynamics in a normal human. Gastroenterology 13:1–8, July, 1949.
Shohl, A. T., May, C. D., and Shwachman, H.: Studies of nitrogen and fat metabolism on infants and children with pancreatic fibrosis. J. Pediat. 23:267–279, Sept., 1943.
Shwachman, H., Patterson, R., and Laguna, J.: Studies in pancreatic flbrosis; a simple diagnostic gelatin film test for stool trypsin. Pediatrics 4:222–230, Aug., 1949.
Spiro, H. M., Reifenstein, R. W., and Gray, S. J.: Effect of adrenocortieotropic hormone upon uropepsin excretion. J. Lab. & Clin. Med. 35:899–910, June, 1950.
Sunderman, F. U., and Boerner, F.: Normal Values in Clinical Medicine. W. B. Saunders Co., Philadelphia, Pa., 1949.
Thomas, J. E.: External Secretion of the Pancreas. Chas. C. Thomas, Publisher, Springfield, Ill., 1950.
Wainwright, C. W.: Intrapancreatic obstruction. New England J. Med. 244:161–170, Feb. 1, 1951.
Wollaeger, E. E., Comfort, M. W., Clagett, O. T., and Osterberg, A. E.: Efficiency of gastrointestinal tract after resection of head of pancreas. J. A. M. A. 137:838–848, July 3, 1948.
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No objection to publication on grounds of military security 6 August, 1952 (LGA), office of the Surgeon General, department of the Army, by authority, office of Public Information Department of Defense.
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Spiro, H.M. Practical diagnosis of pancreatic disease. Amer. Jour. Dig. Dis. 20, 78–84 (1952). https://doi.org/10.1007/BF02885564
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DOI: https://doi.org/10.1007/BF02885564