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Comparative FTIR spectroscopic analysis of human breast benign and malignant tissues

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Chinese Science Bulletin

Abstract

Some remarkable FTlR spectral differences are observed and the differences at the molecular level are extracted between benign and malignant breast tissue samples. For the malignant tissue, the relative content of nucleic acids is increased whereas the collagen is decreased. The proteins are phosphorylated and become more flexible and disordered. And these significant differences have important implications not only for probing the process of the breast lesion at the molecular level, but also for evaluating the histological types and grades of breast diseases.

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Authors and Affiliations

  1. Department of Chemistry, Peking Uniccrsiry, 100871, Beijing, China

    Yunxiang Ci, Tiyu Gao & Jun Feng

  2. Department of Biology, Peking Univiersity, 100871, Beijing, China

    Zhenquan Guo

  3. Department of Pathology, Heijing Medical University, 100044, Beijing, China

    Xiu Kan & Jiangqiang Dong

Authors
  1. Yunxiang Ci
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  2. Tiyu Gao
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  3. Jun Feng
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  4. Zhenquan Guo
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  5. Xiu Kan
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  6. Jiangqiang Dong
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Cite this article

Ci, Y., Gao, T., Feng, J. et al. Comparative FTIR spectroscopic analysis of human breast benign and malignant tissues. Chin. Sci. Bull. 44, 804–808 (1999). https://doi.org/10.1007/BF02885024

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  • DOI: https://doi.org/10.1007/BF02885024

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