Abstract
Normal and alloxan induced diabetic guinea pigs were kept on whole seed diet of green gram for 4 weeks. Serum total lipids were found to be significantly decreased in both normal and diabetic guinea pigs (P <0.001)—Both free and esterified fractions of cholesterol were found to be lowered significantly in diabetic animals (P<0.05; <0.01, respectively), whereas only esterified fraction was reduced significantly in case of normals (P<0.05). Significant lowering of triglyceride levels (P<0.01) was also noticed in both normal as well as diabetic guinea pigs while phospholipids remained almost unaffected. Green gram feeding decreased the total cholesterol / phospholipid ratio from 0.630 to 0.625 in normal and from 1.039 to 0.850 in diabetic guinea pigs indicating its antiatherogenic nature.
Similar content being viewed by others
References
Kannel, W.B. andMc Gee, D.L. (1979), J.A.M.A.241, 2035–2038.
Kannel, W.B. andMc Gee, D.L. (1979) Circulation59, 8–13.
Stamler, J. (1978), Arch. Surg.113, 21–25.
Mayes, P.A. (1977) in Review of physiological chemistry (Harper, H.A., Rodwell, V.W. and Mayes, P.A., Eds) pp 280–320, Lange Medical publications, Maruzen company Ltd. California.
Albrink M.J. andMan, E.B. (1959), Arch. Intero. Med.103, 4.
Hulley, S.B., Roseman, R.H., Bowol, R.D. et al (1980) New Engl. J. Med.302, 1383.
Srivastava, A., Longia, G.S., Singh, S.P. andJoshi, L.D. (1987), Ind. J. Physiol. Pharma.31, 77–83.
Patricio, H. andWillard, J.V. (1979) J. Nutr.109, 32–38.
Soni, G.L., Sohal, B.S. andSingh, R. (1979), Ind. J. Biochem. Biophys.16, 444–446
Kritchevsky, D., Kolman, R.R., Guttmacher, R.M. andForbes, M. (1959), Arch. Biochem.85, 444–451.
Anderson, J.T., Grande, F. andKeys, A. (1971), Am. J. Clin. Nutr.24, 524–530.
Sirtori, C.R., Agradi, E., Couti, F. Mantero, O. andGatti, E. (1977), Lancet1, 275–277
Caroll, K.K. (1978), Nutr. Rev.36, 1–5.
Yadav, N.R. andLiener, I.E. (1977), Nutr. Rept. Int.16. 385–389.
Davidson, S.S., Passmore, R., Brock, J.F. andTruswell, A.S. (1975), In Human Nutrition and Dietetics, pp 422, Churchill Livingstone, London.
Kiehm, T.G., Anderson, J.W. andWard, K. (1976) Am. J. Clin. Nutr.19, 895–899.
Kritchevsky, D. andStory, J.A. (1974), J. Nutri.104, 458.
Eastwood, M.A., Anderson, R., Mitchell, W.D., Robertson, J. andPocock, S. (1976), J. Nutr.106, 1429.
Joshi, L.D., Singhal, P.C. andGupta, R.K. (1979), Curr. Sci.48, 684.
Capell, D.F. andAnderson, J.R. (1971), In Muir’s Text Book of Pathology IX edn., pp 268, Edward Arnold Publication, London.
Pandey, A.K. andPandey, K.C. (1977), Indian J. Exp Biol.15, 569.
Nelson, N. (1944) J. Biol. Chem.120, 51;Somogyi, M. andNelson, N. (1945), J. Biol. Chem.160, 69.
Frings, C.S., Fendley, T.W., Dunn, R.T. andQueen, C.A. (1972), Clin. Chem.18, 673.
Wootton, I.D.P. (1964) in Microanalysis in medical biochemistry, pp 86, Churchill Ltd. London.
Gottfried, S.P. andRosenberg, B. (1973), Clin. Chem.19, 1077.
Connerty, H.V., Briggs, A.R. andEaton, J.E.H. (1961) Clin. Chem.7, 37.
Grande, F., Anderson, J.T. andKeys, A. (1965), J. Nutr.86 313.
Devi, S.K. andKurup, P.A. (1972), Atherosclerosis15, 223–230.
Nishida, T.A.V. andKummerow, F.A. (1960), Circ. Res.8, 742.
Dixit, V.P. andJoshi, S.C. (1985), Ind. J. Physiol. Pharmac.29, 47–50.
Rifkind, B.M., Goor, R.S. andLevy, R.I. (1979) in The medical clinics of North America. Symposium on Applied Nutrition in Clinical Medicine 63, pp. 911–926, W.B. Saunders Company, Philadelphia.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Srivastava, A., Joshi, L.D. & Singh, S.P. Changes in serum lipids in normal and diabetic guinea pigs on feeding Phaseolus aureus (Green gram). Indian J Clin Biochem 4, 50–57 (1989). https://doi.org/10.1007/BF02867652
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02867652