Abstract
Voltage-and ligand-gated ion channels are key players in synaptic transmission and neuron-glia communication in the nervous system. Expression of these proteins can be regulated at several levels (transcriptional, translational, or posttranslational) and by multiple extracellular factors in the developing and mature nervous system. A wide variety of hormones and growth factors have been identified as important in neural cell differentiation, which is a complex process involving the acquisition of cell-type-specific ion channel phenotypes. Much literature has already accumulated describing the structural and functional characteristics of ion channels, but relatively little is known about the factors that influence their synthesis and cell surface expression, although this area has generated considerable interest in the context of neural cell development. This article reviews several examples of regulated expression of these channels by cellular factors, namely peptide growth factors and steroid hormones, and discusses, where applicable, current understanding of molecular mechanisms underlying such regulation of voltage-and neurotransmitter-gated ion channels.
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Abbud R. and Smith M. S. (1991) Differences in the luteinizing hormone and prolactin responses to multiple injections of kainate as compared to N-methyl-D,L-aspartate, in cycling rats.Endocrinology 129, 3254–3258.
Acheson A., Barker P. A., Anderson R. F., Miller F. D., and Murphy R. A. (1991) Detection of brainderived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibody to NGF.Neuron 7, 265–273.
Agnew W. S. (1984) Voltage-regulated sodium channel molecules.Ann. Rev. Physiol. 46, 517–530.
Akopian A. N., Sivilotti L., and Wood J. N. (1996) A tetrodoxin-resistant voltage-gated sodium channel expressed by sensory neurons.Nature 379, 258–262.
Akwa Y., Sawawes N., Robel P., Baulieu E. E., and Le Goascogne C. (1993) Astrocytes and neurosteroids: metabolism of prenenolone and dehydroepiandrosterone. Regulation by cell density.J. Cell Biol. 121, 135–143.
Alemá S., Casalbore P., Agostini E., and Tató F. (1985) Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene.Nature 316, 557–559.
Alonso R. and Lopez-Coviella I. (1998) Gonadal steroids and neuronal function.Neurochem. Res. 23, 675–688.
Altiok N., Bessereau J. L., and Changeux J. P. (1995)ERBB3 and ERBB2/NEU mediate the effect of heregulin on acetylcholine-receptor gene expression in muscle-differential expression at the endplate.EMBO J. 14, 4258–4266.
Amy C. M. and Bennett E. L. (1983) Increased sodium ion conductance through nicotinic acetylcholine receptor channels in PC12 cells exposed to nerve growth factors.J. Neurosci. 3, 1547–1553.
Araki T. and Tohyama M. (1992) Region-specific expression of GABAA receptor α3 and α4 subunit mRNAs in the rat brain.Mol. Brain Res. 12, 293–314.
Attardi B., Takimoto K., Gealy R., Severns C., and Levitan E. S. (1993) Glucocorticoid induced upregulation of a pituitary K+ channel mRNAin vitro andin vivo.Rec. Channels 1, 287–293.
Aubry J-M., Bartanusz V., Pagliusi S., Schulz P., and Kiss J. Z. (1996) Expression of ionotropic glutamate receptor subunit mRNAs by paraventricular corticotropin-releasing factor (CRF) neurons.Neurosci. Lett. 205, 95–98.
Auld V. J., Goldin A. L., Krafte D. S., Marshall J., Dunn J. M., Catterall W. A., Lester H. A., Davidson N., and Dunn R. J. (1988) A rat brain Na+ channel α-subunit with novel gating properties.Neuron 1, 449–461.
Bai G. and Kusiak J. W. (1993) Cloning and analysis of the 5′ flanking sequence of the rat N-methyl-D-aspartate receptor 1 (NMDAR1) gene.Biochim Biophys. Acta 1152, 197–200.
Bai G. and Kusiak J. W. (1995) Functional analysis of the proximal 5′-flanking region of the N-methyl-D-aspartate receptor subunit gene.J. Biol. Chem. 270, 7737–7744.
Bai G. and Kusiak J. W. (1997) Nerve growth factor up-regulates the N-methyl-D-aspartate receptor subunit 1 promoter in PC12 cells.J. Biol. Chem. 272, 5936–5942.
Bai G., Norton D. D., Prenger M. S., and Kusiak J. W. (1998) Single-stranded DNA-binding proteins and neuron-restrictive silencer factor participate in cell-specific transcriptional control of the NMDAR1 gene.J. Biol. Chem. 273, 1086–1091.
Bain G., Ray W. J., Yao M., and Gottlieb D. I. (1994) From embryonal carcinoma cells to neurons: the p19 pathway.Bioassays 16, 343–348.
Bandtlow C. E., Heumann R., Schwab M. E., and Thoenen H. (1987) Cellular localization of nerve growth factor synthesis by in situ hybridization.EMBO J. 6, 891–899.
Banner L. R. and Patterson P. H. (1994) Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia.Proc. Natl. Acad. Sci. USA 91, 7109–7113.
Barbacid M., Lamballe F., Pulido D., and Klein R. (1991) The trk family of tyrosine protein kinase receptors.Biochim. Biophys. Acta 1072, 115–127.
Barres B. A., Chun L. L. Y., and Corey D. P. (1989) Calcium current in cortical astrocytes: induction by cAMP and neurotransmitters and permissive effect of serum factors.J. Neurosci. 9, 3169–3175.
Barres B. A., Koroshetz W. J., Chun L. L. Y., and Corey D. P. (1990a) Ion channel expression by white matter glia: the type-1 astrocyte.Neuron 5, 527–544.
Barres B. A., Koroshetz W. J., Swartz K. J., Chun L. L. Y., and Corey D. P. (1990b) Ion channel expression by white matter glia: the O-2A glial progenitor cell.Neuron 4, 507–524.
Bartanusz V., Aubry J-M., Pagliusi S., Jezova D., Baffi J., and Kiss J. Z. (1995) Stress-induced changes in messenger RNA levels of N-methyl-D-aspartate and AMPA receptor subunits in selected regions of the rat hippocampus and hypothalamus.Neuroscience 66, 247–252.
Baulieu E. E. and Robel P. (1995) Non-genomic mechanisms of action of steroid hormones, inNon-Reproductive actions of Sex Steroids, (Bock G. R. and Goode J. A., eds.) Ciba Foundation Symposium 191, Wiley, Chichuster, UK, pp. 24–42.
Beattie C. E. and Siegel R. E. (1993) Developmental cues modulate GABAA receptor subunit mRNA expression in cultured cerebellar granule neurons.J. Neurosci. 13, 1784–1792.
Beckh S. and Pongs O. (1990) Members of the RCK potassium channel family are differentially expressed in the rat nervous system.EMBO J. 7, 2457–2463.
Behrens M. I. and Latorre R. (1991) Potassium channels in developing excitable cells.Curr. Topic Membr. 39, 325–355.
Ben-Ari Y., Khazipov R., Leinekugel X., Caillard, O., and Gaiarsa J.-L. (1997) GABAA, NMDA and AMPA receptors: a developmentally regulated «menage a trois».Trends Neurosci. 20, 523–529.
Bernal J. and Nunez J. (1995) Thyroid hormones and brain development.Eur. J. Endocrinol. 133, 390–398.
Bessis A., Champtiaux N., Chatelin L., and Changeux J.-P. (1997) The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brainProc. Natl. Acad. Sci. USA 94, 5906–5911.
Bessis A., Savatier N., Devillers-Thiery A., Bejanin S., and Changeux J.-P. (1993) Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor alpha-2 subunit gene.Nucleic Acids Res. 21, 2185–2192.
Bigger C. B., Casanova E. A., and Gardner P. D. (1996) Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes: functional interactions between Sp1 and the rat β4 subunit gene promoter.J. Biol. Chem. 271, 32,842–32,848.
Bigger C. B., Melnikova I. N., and Gardner P. D. (1997) Sp1 and Sp3 regulate expression of the neuronal nicotinic acetylcholine receptor beta 4 subunit gene.J. Biol. Chem. 272, 25,976–25,982.
Birnbauer L., Campbell K. P., Catterall W. A., Harpold M. M., Hofmann F., Horne W. A., Mori Y., Schwartz A., Snutch T. P., Tanabe T., and Tsien R. W. (1994) The naming of voltage-gated calcium channels.Neuron 13, 505,506.
Black J. A. and Waxman S. G. (1996) Sodium channel expression: a dynamic process in neurons and non-neuronal cells.Dev. Neurosci. 18, 139–152.
Bothwell M. A., Schechter A. L., and Vaughn K. M. (1980), Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factor.Cell 21, 857–866.
Boulter J., Evans J., Goldman D., Martin G., Treco D., and Heinemann S. (1986) Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit.Nature 319, 368–374.
Boulter J., O'Shea-Greenfield A., Duvosin R. M., Connolly J. G., Wada E., Jensen A., Gardner P. D., Ballivet M., Deneris E. S., McKinnon D., Heinemann S., and Patrick J. (1990) α3, α5 and β4: three members of the rat neuronal nicotinic acetycholine receptor-related gene family form a gene cluster.J. Biol. Chem. 265, 4472–4482.
Brann D. W. and Mahesh V. B. (1994) Excitatory amino acids: function and significance in reproduction and neuroendocrine regulation.Front. Neuroendocrinol. 15, 3–49.
Brann D. W., Zamorano P. L., Chorich L. P., and Mahesh V. B. (1993) Steroid hormone effects on NMDA receptor binding and NMDA receptor mRNA levels in the hypothalamus and cerebral cortex of the adult rat.Neuroendocrinology 58, 666–672.
Buller A. L., Larson H. C., Schneider B. E., Beaton J. A., Morrisett R. A., and Monaghan D. T. (1994) The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition.J. Neurosci. 14, 5471–5484.
Bureau M. H., and Olsen R. W. (1993) GABAA receptor subtypes—ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography.J. Neurochem. 61, 1479–1491.
Burnstein D. E. and Greene L. A. (1982) Nerve growth factor has both mitogenic and anti-mitogenic activity.Dev. Biol. 94, 477–482.
Burt D. R. and Kamatchi G. L. (1991) GABAA receptor subtypes—from pharmacology to molecular biology.FASEB J. 5, 2916–2923.
Caffrey J. M., Eng D. L., Black J. A., Waxman S. G., and Kocsis J. D. (1992) Three types of sodium channels in adult dorsal root ganglion neurons.Brain Res. 592, 283–297.
Canonaco M., Tavolaro R., and Maggi A. (1993) Steroid hormones and receptors of the GABAA supramolecular complex.Neuroendocrinology 57, 974–984.
Carbona S., Szwarcfarb B., Rondina D., Feleder C., and Moguilevsky J. A. (1996) Differential effects of the N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of the excitatory amino acids system on LH and FSH secretion. Its effects on the hypothalamic luteinizing hormone releasing hormone during maturation in male rats.Brain Res. 707, 139–145.
Carraway K. L. and Burden S. J. (1995) Neuregulins and their receptors.Curr. Opin. Neurobiol. 5, 606–612.
Catterall W. A. (1984) The molecular basis of neuronal excitability.Science 223, 653–661.
Cauley K., Marks M., Gahring L. C., and Rogers S. W. (1996) Nicotinic receptor subunits α3, α4 and β2 and high affinity nicotine binding sites are expressed by P19 embryonal cells.J. Neurobiol. 30, 303–314.
Cens T., Nargeot J., and Charnet P. (1997) Ca2+-permeability of muscle nicotinic acetylcholine receptor is increased by expression of the ε subunit.Rec. Channels 5, 29–40.
Changeux J. P., Duclert A., and Sekine S. (1992) Calcitonin gene-related peptides and neuromuscular interactions.Ann. NY Acad. Sci. 657, 361–378.
Chazot P. L., Coleman S. K., Cik M., and Stephenson F. A. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the co-existence of three subunit types within a discrete receptor molecule.J. Biol. Chem. 269, 24,403–24,409.
Cheng B., Furukawa K., O'Keefe J. A., Goodman Y., Kihiko M., Fabian T., and Mattson M. P. (1995) Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons.J. Neurochem. 6, 2525–2536.
Chew L.-J., Fleck M. W., Wright P., Scherer S. E., Mayer M. L., and Gallo V. (1997) Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells.J. Neurosci. 17, 227–240.
Chiu S. Y. and Wilson G. F. (1989) The role of potassium channels in Schwann cell proliferation in Wallerian degeneration of explant rabbit sciatic nerves.J. Physiol. (Lond.) 408, 199–222.
Chu G. C., Moscoso L. M., Sliwkowski M. X., and Merlie J. P. (1995) Regulation of the acetylcholine receptor epsilon subunit gene, by recombinant ARIA—an in vitro model for transynaptic gene regulation.Neuron 14, 329–339.
Cintra A., Fuxe K., Harfstrand A., Agnati L. F., Miller L. S., Greene J. L., and Gustafsson J. (1986) On the cellular localisation and distribution of estrogen receptors in the tel- and diencephalon using monoclonal antibodies to human estrogen receptor.Neurochem. Int. 8, 587–595.
Cobas A., Fairen A., Alvarez-Bolado G., and Sanchez M. P. (1991) Prenatal development of the intrinsic neurons of the rat neocortex: a comparative study of the distribution of GABA-immunoreactive cells and the GABAA receptor.Neuroscience 40, 375–397.
Cohen-Cory S., Dreyfus C. F., and Black I. B. (1991) NGF and excitatory neurotransmitters regulate survival and morphogenesis of cultured cerebellar Purkinje cells.J. Neurosci. 11, 462–471.
Corriveau R. A. and Berg D. K. (1994) Neurons in culture maintain acetylcholine receptor levels with far fewer transcripts thanin vivo.J. Neurobiol. 25, 1579–1592.
Corriveau R. A., Romano S. J., Conroy W. G., Oliva L., and Berg D. K. (1995) Expression of neuronal acetylcholine receptor genes in vertebrate skeletal muscle during development.J. Neurosci. 15, 1372–1383.
Corvalan V., Cole R., deVellis J., and Hagiwara S. (1990) Neuronal modulation of calcium channel activity in cultured rat astrocytes.Proc. Natl. Acad. Sci. USA 87, 4345–4348.
Costa A., Yasin S. A., Hucks D., Forsling M. L., Besser G. M., and Grossman A. (1992) Differential effects of neuroexcitatory amino acids on corticotropin-releasing hormone-41 and vasopressin release from rat hypothalamic explants.Endocrinology 131, 2595–2602.
Couturier S., Bertrand D., Matter J., Hernandez M., Bertrand S., Millar N., Valera S., Barkas T., and Ballivet M. (1990) A neuronal nicotinic acetylcholine receptor subunit (α7) is, developmentally regulated and forms a homomeric channel blocked by α-bungarotoxin.Neuron 5, 847–856.
Cowley S., Paterson H., Kemp P., and Marshall C. J. (1994) Activation of MAP kinase is necessary and sufficient for PC12 differentiation and transformation of NIH 3T3 cells.Cell 77, 841–852.
Cremins J., Wagner J. A., and Haleguoa S. (1986) Nerve growth factor action is mediated by cAMP- and Ca2+/phospholipid-dependent protein kinases.J. Cell. Biol. 103, 887–893.
Crosby S. D., Puetz J. J., Simburger K. S., Fahrner T. J., and Milbrandt J. (1991) The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.Mol. Cell Biol. 11, 3835–3841.
Crowley C., Spencer S. D., Nishimura N. C., Chen K. S., Pitts-Meek S., Armanini M. P.., Ling, L. H., MacMahon S. B., Shelyton D. L., Levinson A. D., and Phillips H. S. (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons.Cell 76, 1001–1011.
Csillik B., Rakic P., and Knyihar-Csillik E. (1998) Peptidergic innervation and the nicotinic acetylchline receptor in the primate basal nucleus.Eur. J. Neurosci. 10, 573–585.
Curtis R., Scherer S. S., Somogyi R., Adryan K. M., lp N. Y., Zhu Y., Lindsay R. M., and DiStefano P. S. (1994) Retrograde axonal transport of LIF is increased by peripheral nerve injury: correlation with increased LIF expression in distal nerve.Neuron 12, 191–204.
Cutting G. R., Lu L., O'Hara B. F.., Kasch L. M., Montrose-Rafizadeh C., Donovan D. M., Shimada S., Antonavakis S. E., Guggino W. B., and Uhl G. R. (1991) Cloning of the gamma-aminobutyric acid (GABA) rho I cDNA: a GABA receptor subunit highly expressed in the retina.Proc. Natl. Acad. Sci. USA 88, 2673–2677.
D'Arcangelo G. and Halegoua S. (1993) A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions.Mol. Cell. Biol. 13, 3146–3155.
D'Arcangelo G., Paradiso K., Shepherd D., Brehm P., Halegoua S., and Mandel G. (1993) Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways.J. Cell Biol. 4, 915–921.
Damon D., D'Amore P. A., and Wagner J. A. (1990) Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms.J. Cell. Biol. 110, 1333–1339.
Darlington D. N., Miyamoto M., Keil L., and Dallman M. (1989) Paraventricular stimulation with glutamate elicits bradycardia and pituitary responses.Am. J. Physiol. 256, R112-R119.
DeCoursey T. E., Chandy K. G., Gupta S., and Cahalan M. D. (1984) Voltage-gated K+ channels in human T-lymphocytes: a role in mitogenesis?Nature 307, 465–468.
De Jongh K. S., Warner C., and Catterall W. A. (1990) Subunits of purified, calcium channels. Alpha 2 and delta are encoded by the same gene.J. Biol. Chem. 265, 14,738–14,741.
De Kloet E. R. (1991) Brain corticosteroid receptor balance and homeostatic control.Frontiers Neuroendocrinol. 12, 95–164.
De Vries G. J., De Bruin J. P. C., Uylings H. B. M., and Corner M. A., eds. (1984)Prog. Brain Res., vol. 61.
Deneris E. S., Boulter J., Swanson L. W., Patrick J., and Heinemann S. (1989) β3: a new member of nicotinic acetylcholine receptor gene family is expressed in brain.J. Biol. Chem. 264, 6268–6272.
Diano S., Naftolin F., and Horvath T. L. (1997) Gonadal steroids target AMPA glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: a morphological and biochemical study.Endocrinology 138, 778–789.
Dib-Hajj S. D., Black J. A., Cummins T. R., Kenney A. M., Kocsis J. D., and Waxman S. G. (1998) Rescue of α-SNS sodium channel expression in small dorsal root ganglion neurons following axotomy by in vivo administration of nerve growth factor.J. Neurophysiol. 79, 2668–2678.
Dietzell. (1995) Voltage-gated ion currents in embryogenesis.Persp. Dev. Neurobiol. 2, 293–308.
Donaldson L. W., Petersen J. M., Graves B. J., and McIntosh L. P. (1996) Solution structure of the ETS domain from murine Ets-1: a winged helix-turnhelix DNA binding motif.EMBO J. 15, 125–134.
Dourado M. M. and Dryer S. E. (1992) Changes in the electrical properties of chick ciliary ganglion neurones during embryonic development.J. Physiol. (Lond.) 449, 411–428.
Dourado M. M. and Dryer S. E. (1994) Regulation of A-currents by cell-cell interactions and neurotrophic factors in developing chick parasympathetic neurones.J. Physiol. (Lond.) 474, 367–377.
Drewe J. A., Verma S., Frech G., and Joho R. H. (1992) Distinct spatial and temporal expression patterns of K+ channel mRNAs from different subfamilies.J. Neurosci. 12, 538–548.
Dryer S. E. (1994) Functional development of the parasympathetic neurons of the avian ciliary ganglion: a classic model system for the study of neuronal differentiation and development.Progr. Neurobiol. 43, 281–322.
Du Q., Tomkinson A. E., and Gardner P. D. (1997) Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes: a possible role for the DNA binding protein Purα.J. Biol. Chem. 272, 14990–14995.
Duffy S., Fraser D. D., and MacVicar B. A. (1995) Potassium channels, inNeuroglia (Kettenmann H. and Ransom B. R.), eds.. Oxford University Press, New York, pp. 185–201.
Dussault J. H. and Ruel J. (1987) Thyroid hormones and brain development.Ann. Rev. Physiol. 49, 321–334.
Elgoyhen A., Johnson D., Boulter J., Velter D., and Heinemann S. (1994) α9, an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells.Cell 79, 705–715.
Ellis S. B., Williams M. E., Ways N. R., Brenner R., Sharp A. H., Leung A. T., Campbell K. P., McKenna E., Koch W. J., Hui A., Schwartz A., and Harpold M. M. (1988) Sequence and expression of mRNAs encoding the α1 and the α2 subunits of a DHP-sensitive calcium channel.Science 241, 1661–1664.
Falls D. L., Rosen K. M., Corfas G., Lane W. S., and Fischbach G. D. (1993) ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the NEU ligand family.Cell 72, 801–815.
Fanger G. R., Brennan C., Henderson L. P., Gardner P. D., and Maue R. A. (1995) Differential expression of sodium channels and nicotinic acetylcholine receptor channels in nnr variants of the PC12 pheochromocytoma cell line.J. Memb. Biol. 144, 71–80.
Farah J. M., Rao T. S., Mick S. J., Coyne K. E., and Lyegenar S. (1991) N-methyl-D-aspartate treatment increases circulating adrenocorticotropin and luteinizing hormone in the rat.Endocrinology 128, 1875–1880.
Federoff H. J., Geschwind M. D., Geller A. I., and Kessler J. A. (1992) Expression of nerve growth factor in vivo from a defective Herpes simplex virus I vector prevents effects of axotomy on sympathetic ganglia.Proc. Natl. Acad. Sci. USA 89, 1636–1640.
Felts P. A., Yokoyama S., Dib-Hajj S., Black I. J. A., and Waxman S. G. (1997) Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.Mol. Brain Res. 45, 71–82.
Fiszman M. L., Novotny E. A., Lange G. D., and Barker J. L. (1990). Embryonic and early postnatal hippocampal cells respond to nanomolar concentrations of muscimol.Dev. Brain Res. 53, 186–193.
Fitzgerald E. M. and Dolphin A. C. (1997) Regulation of rat neuronal voltage-dependent calcium channels by endogeneous p21-ras.Eur. J. Neurosci. 9, 1252–1261.
Flood J. F., Morley J. E., and Roberts E. (1992) Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.Proc. Natl. Acad. Sci. USA 89, 1567–1571.
Flores C. M., Rogers S. W., Pabreza L. A., Wolfe B. B., and Kellar K. J. (1992) A subtype of nicotinic cholinergic receptor in rat brain is comprised of α4 and β2 subunits and is up-regulated by chronic nicotine treatment.Mol. Pharmacol. 41, 31–37.
Fontaine B., Klarsfeld A., and Changeux J-P. (1987) Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alphasubunit mRNA levels by distinct intracellular pathways.J. Cell Biol. 5, 1337–1342.
Friedman B., Scherer S. S., Rudge J. S., Helgren M., Morrisey D., McClain J., Wang D., Weigand S. J., Lindsay R. M., and Ip N. Y. (1992) Regulation of ciliary neurotrophic factor expression in myelinrelated Schwann cells in vivo.Neuron 9, 295–305.
Fyodorov D., Nelson T., and Deneris E. (1998) Pet-1, a novel ETS domain factor that can activate neuronal nAChR gene transcription.J. Neurobiol. 34, 151–163.
Gallin W. J. and Greenberg M. E. (1995) Calcium regulation of gene expression in neurons: the mode of entry matters.Curr. Opin. Neurobiol. 5, 367–374.
Gallo V., Ciotti M. T., Coletti A., Aloisi F., and Levi G. (1982) Selective release of glutamate from cerebellar granule cells differentiating in culture.Proc. Natl. Acad. Sci. USA 79, 7919–7923.
Gallo V., Zhou J. M., McBain C. J., Wright P. W., Knutson P. L., and Armstrong R. C. (1996) Oligodendrocyte progenitor cell proliferation and lineage progression are regulated by glutamate receptor-mediated K+ channel block.J. Neurosci. 16, 2659–2670.
Galzi J. L. and Changeux J. P. (1995) Neuronal nicotinic receptors: molecular organization and regulation.Neuropharmacology 34, 563–582.
Gambarana C., Beattie C. E., Rodriguez Z. R., and Siegel R. E. (1991) Region-specific expression of messenger RNAs encoding GABAA receptor subunits in the developing rat brain.Neuroscience 45, 423–432.
Gambarana C., Pittman R., and Siegel R. E. (1990) Developmental expression of the GABAA receptor α1 subunit mRNA in the rat brain.J. Neurobiol. 21, 1169–1179.
Gautron S., Dos Santos G., Pinto-Henrique D., Koulakoff A., Gros F., and Berwald-Netter Y. (1992) The glial voltage-gated sodium channel: cell-and tissue-specific mRNA expression.Proc. Natl. Acad. Sci. USA 89, 7272–7276.
Gazzaley A. H., Weiland N. G., McEwen B. S., and Morrison J. H. (1996) Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus.J. Neurosci. 16, 6830–6838.
George A. L. (1995) Molecular genetics of ion channels diseases.Kidney Int. 48, 1180–1190.
Gerzanich V., Anand R., and Lindstrom J. (1994) Homomoers of α8 subunits of nicotinic receptors functionally expressed in Xenopus oocytes exhibit similar channel but contrasting binding site properties compared to α7 homomers.Mol. Pharmacol. 45, 212–220.
Gevorkyan E. S., Nazaryan K. B., and Kostanyan A. A. (1989) Modifying effect of estradiol and progesterone on epileptic activity of the rat brain.Neurosci. Behav. Physiol. 19, 412–415.
Ghosh A. and Greenberg M. E. (1995) Calcium signaling in neurons: molecular mechanisms and cellular consequences.Science 268, 239–247.
Ginty D. D., Fanger G. R., Wagner J. A., and Maue R. A. (1992) The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.J. Cell Biol. 116, 1465–1473.
Ginty D. D., Glowacka D., DeFranco C., and Wagner J. A. (1991) Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities.J. Biol. Chem. 266, 15,325–15,333.
Glencorse T. A., Bateson A. N., and Darlison M. G. (1991) Sequence of the chicken GABA-A receptor gamma2 subunit cDNA.Nucleic Acids Res. 10, 7157.
Gomez N. and Cohen P. (1991) Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases.Nature 353, 170–173.
Gospodarowicz D., Neufeld G., and Schwigerer L. (1986) Molecular and biological characterization of fibroblast growth factor, an angiogenic factor which also controls proliferation and differentiation of mesoderm and neuroectoderm derived cells.Cell Differ. 19, 1–17.
Gottmann K., Dietzel I. D., Lux H. D., Huck S., and Rohrer H. (1988) Development of inward currents in chick sensory and autonomic neuronal precursor cells in culture.J. Neurosci. 8, 3722–3732.
Gottmann K., Rohrer H., and Lux H. D. (1991) Distribution of Ca2+ and Na+ conductances during neuronal differentiation of chick DRG precursor cells.J. Neurosci. 11, 3371–3378.
Gould E., Woolley C. S., Frankfurt M., and McEwen B. S. (1990) Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood.J. Neurosci. 10, 1286–1291.
Grantyn R., Perouansky M., Rodriguez-Tebar A., and Lux H. D. (1989) Expression of depolarizing voltage-and transmitter-activated currents in neuronal precursor cells from the rat brain is preceded by a proton-activated sodium current.Dev. Brain Res. 49, 150–155.
Greene L. A. and Kaplan D. R. (1995) Early events in neurotrophin signalling via Trk and p75 receptors.Curr. Opin. Neurobiol. 5, 579–587.
Greene L. A. and Tischler A. S. (1982) PC12 pheochromocytoma cells in neurobiology research.Adv. Cell. Neurobiol. 3, 373–414.
Greene L. A. and Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.Proc. Natl. Acad. Sci. USA 73, 2424–2428.
Greensmith L., Hasen H. I., and Vrbova G. (1994) Nerve injury increases the susceptibility of motoneurons to N-methyl-D-aspartate-induced neurotoxicity in the developing rat.Neuroscience 58, 727–733.
Gu H. J., Wenger B. W., Lopez I., McKay D. B., and Boyd R. T. (1996) Characterization and localization of adrenal nicotinic acetylcholine receptors: evidence that mAb35—nicotinic receptors are the principal receptors mediating adrenal catecholamine secretion.J. Neurochem. 66, 1454–1461.
Gurantz D., Harootunian A. T., Tsien R. Y., Dionne V. E., and Margiotta J. F. (1994) VIP modulates neuronal nicotinic acetylcholine receptor function by a cyclic AMP-dependent mechanism.J. Neurosci. 14, 3540–3547.
Gustafson T. A., Clevinger E. C., O'Neill T. J., Yarowsky P. J., and Krueger B. K. (1993) Mutually exclusive exon splicing of type III brain sodium channel alpha subunit RNA generates developmentally regulated isoforms in rat brain.J. Biol. Chem. 268, 18,648–18,653.
Haas S., Thatikunta P., Steplewski A., Johnson E. M., Khaliki K., and Amini S. (1995) A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells.J. Cell Biol. 130, 1171–1179.
Hagihara K., Hirata S., Osada T., Hirai M., and Kato J. (1992) Distribution of cells containing progesteron receptor mRNA in the female rat di- and telencephalon: anin situ hybridization study.Mol. Brain Res. 14, 239–249.
Halegoua S., Armstrong R. C., and Kremer N. E. (1991) Dissecting the mode of action of a neuronal growth factor, inCurrent Topics in Microbiology and Immunology, vol. 165 (Bothwell M., ed.) Springer-Verlag, Berlin, pp. 119–170.
Hardingham G. E., Chawla S., Johnson C. M., and Bading H. (1997) Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression.Nature 385, 260–265.
Harris R. A., Mihic S. J., Dildymayfield J. E., and Machu T. K. (1995) Actions of anaesthetics on ligand-gated ion channels—role of receptor subunit composition.FASEB J. 9, 1454–1462.
Hartshorne R. P., Messner D. J., Coppersmith J. C., and Catterall W. A. (1982) The saxitoxin-receptor of the sodium channel from rat brain: evidence for two non-identical β-subunits.J. Biol. Chem. 257, 13888–13891.
Harvey R. J., Chinchetru M. A., and Darlison M. G. (1994) Alternative splicing of a 51-nucleotide exon that encodes a putative protein kinase C phosphorylation site generates two forms of the chicken γ-aminobutyric acidA receptor β2 subunit.J. Neurochem. 62, 10–16.
Hefti F., Hartikka J., and Knusel B. (1989) Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases.Neurobiol. Aging 10, 515–533.
Henderson C. E. (1996) Role of neurotrophic factors in neuronal development.Curr. Opin. Neurobiol. 6, 64–70.
Henderson L. P., Gdovin M. J., Liu C. L., Gardner P. D., and Maue R. A. (1994) Nerve growth factor increases nicotinic acetylcholine receptor gene expression and current density in wild type and protein kinase A-deficient PC12 cells.J. Neurosci. 14, 1153–1163.
Herb A., Burnashev N., Werner P., Sakmann B., Wisden W., and Seeburg P. H. (1992) The KA2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits.Neuron 8, 775–785.
Herbison A. E. (1997) Estrogen regulation of GABA transmission in rat preoptic area.Brain Res. Bull. 44, 321–326.
Herbison A. E. and Fenelon V. S. (1995) Estrogen regulation of GABAA receptor subunit mRNA expression in preoptic area and bed nucleus of the stria terminalis of female rat brain.J. Neurosci. 15, 2328–2337.
Hesen W., Karst H., Meijer O., Cole T. J., Schmid W., de Kloet E. R., Schütz G., and Joëls M. (1996) Hippocampal cell responses in mice with a targeted glucocorticoid receptor gene disruption.J. Neurosci. 16, 6766–6774.
Hess P. (1990) Calcium channels in vertebrate cells.Annu. Rev. Neurosci. 13, 337–356.
Hill C. E., Belford D. A., Godovac-Zimmerman D. A., and Hendry I. A. (1991) Class 1 heparin binding growth factor promotes the differentiation but not survival of ciliary neurones in vivo.Dev. Brain Res. 63, 13–19.
Hille B. (1992)Ionic Channels of Excitable Membranes. Sinauer Associates. Sunderland, MA.
Hinson A. W., Gu X. Q., Dib-Hajj S., Black J. A., and Waxman S. G. (1997) Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro. Glia21, 339–349.
Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors.Ann. Rev. Neurosci. 17, 31–108.
Honegger P. and Lenoir D. (1980) Triiodothyronine enhancement of neuronal differentiation in aggregating fetal rat brain cells cultured in a chemically-defined medium.Brain Res. 199, 425–434.
Honmou O., Utzschneider D. A., Rizzo M. A., Bowe C. M., Waxman S. G. and Kocsis J. D. (1994) Delayed depolarization and slow sodium currents in cutaneous afferents.J. Neurophysiol. 71, 1627–1637.
Howe J. R. (1996) Homomeric and heteromeric channels formed from the kainate-type subunits GluR6 and KA2 have very small, but different, unitary conductances.J. Neurophysiol. 76, 510–519.
Howe L. R., Leevers S. J., Gomez N., Nakielny S., Cohen P., and Marshall C. J. (1992) Activation of the MAP kinase pathway by the protein kinase raf.Cell 71, 335–342.
Hu M., Bigger C. B., and Gardner P. D. (1995) A novel regulatory element of a nicotinic acetylcholine receptor gene interacts with a DNA binding activity enriched in rat brain.J. Biol. Chem. 270, 4497–4502.
Hu M., Theobald N. L. W., and Gardner P. D. (1994) Nerve growth factor increases the transcriptional activity of the rat neuronal nicotinic acetylcholine receptor β4 subunit promoter in transfected PC12 cells.J. Neurochem. 62, 392–395.
Hughes R. A., Sendtner M., and Thoenen H. (1993) Members of several gene families influence survival of rat motoneurons in vitro and in vivo.J. Neurosci. Res. 36, 663–671.
Huguenard J. R., Hamill, O. P., and Prince D. A. (1988) Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component.J. Neurophysiol. 59, 778–795.
Hullin R., Singer-Lahat D., and Freichel M. (1992) Calcium channel β subunit heterogeneity.EMBO J. 11, 885–890.
Jaiswall R. K., Moodie S. A., Wolfman A., and Landreth G. A. (1994) The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.Mol. Cell. Biol. 14, 6944–6953.
Jan L. Y. and Jan Y. N. (1997a) Voltage-gated and inwardly rectifying potassium channels.J. Physiol. (Lond.) 505, 267–282.
Jan L. Y. and Jan Y. N. (1997b) Cloned potassium channels from eukaryotes and prokaryotes.Ann. Rev. Neurosci. 20, 91–123.
Jezova D., Oliver C., and Jurcovicova J. (1991) Stimulation of adrenocorticotropin but not prolactin and catecholamine release by N-methyl-aspartic acid.Neuroendocrinology 54, 488–492.
Jo S. A., Zhu X., Marchionni M. A., and Burden S. J. (1995) Neuregulins are concentrated at nervemuscle synapse and activate acetylcholine receptor gene expression.Nature 373, 158–161.
Joëls M. and de Kloet E. R. (1992) Control of neuronal excitability by corticosteroid hormones.Trends Neurosci. 15, 25–30.
Joëls M. and de Kloet E. R. (1994) Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems.Prog. Neurobiol. 43, 1–36.
Joëls M. and Karst H. (1995) Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons.J. Neurosci. 15, 4289–4297.
Joëls M., Bosma A., Hendriksen H., Diegenbach P., and Kamphuis W. (1996) Corticosteroid actions on the expression of kainate receptor subunit mRNAs in rat hippocampus.Mol. Brain Res. 37, 15–20.
Johnson E. M. Jr, Koike T., and Franklin J. L. (1992) A calcium set point hypothesis of neuronal dependence on neurotrophic factors.Exp. Neurol. 115, 163–166.
Jones A., Korpi E. R., McKernan R. M., Pelz R., Nusser Z., Makela R., Mellor J. R., Pollard S., Bahn S., Stephenson F. A., Randall A. D., Sieghart W., Womogyi P., Smith A. J. H., and Wisden W. (1997) Ligand-gated ion channel subunit partnerships: GABAA receptor α6 subunit gene inactivation inhibits δ subunit expression.J. Neurosci. 17, 1350–1362.
Jones-Villeneuve E. M. V., McBurney M. W., Rogers K. A., and Kalnins V. I. (1982) Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells.J. Cell Biol. 94, 253–262.
Joseph L. J., Le Beau M. M., Jamieson G. J., Acharya S., Shows T. B., Rowley J. D., and Sukhatme V. P. (1988) Molecular cloning, sequencing, and mapping ofEGR2, a human early growth response gene encoding a protein with “zinc-binding finger” structure.Proc. Natl. Acad. Sci. USA 85, 7164–7168.
Jung-Testas I., Hu Z., Robel P., and Baulieu E. E. (1989) Biosynthesis of prenenolone and progesterone in primary cultures of rat glial cells.Endocrinology 125, 2083–2091.
Kalman D., Wong B., Horvai A. E., Cline M. J., and O'Lague P. H. (1990) Nerve growth factor acts through a cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells.Neuron 2, 355–366.
Kamp T. J., Mitas M., Fields K. L., Asoh S., Chin H., Marban E., and Nirenberg M. (1995) Transcriptional regulation of the neuronal L-type calcium channel αID subunit gene.Cell. Mol. Neurobiol. 15, 307–326.
Kang H. J. and Schuman E. M. (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus.Science 267, 1658–1662.
Karst H., Werkman T. R., Struik M., Bosma A., and Joëls M. (1997) Effects of adrenalectomy on Ca2+ currents and Ca2+ channel subunit mRNA expression in hippocampal CA1 neurons of young rats.Synapse 26, 155–164.
Kayano T., Noda M., Flockerzi V., Takahashi H., and Numa S. (1988) Primary structure of the rat brain sodium channel III deduced from the cDNA sequence.FEBS Lett. 228, 187–194.
Kessler J. A. and Black I. B. (1979) The role of axonal transport in the regulation of enzyme activity in sympathetic ganglia of adult rats.Brain Res. 171, 415–424.
Kettenmann H. and Ransom B. (1995)Neuroglia. Oxford University Press, New York.
Kim H. G., Wang T., Olafsson P., and Lu B. (1994) Neurotrophin 3 potentiates neuronal activity and inhibits γ-aminobutyratergic synaptic transmission in cortical neurons.Proc. Natl. Acad. Sci. USA 91, 12,341–12,345.
Knutson P., Ghiani C. A., Zhou J.-M., Gallo V., and McBain C. J. (1997) K+ channel expression and cell proliferation are regulated by intracellular sodium and membrane depolarization in oligodendrocyte progenitor cells.J. Neurosci. 17, 2669–2682.
Kobrinsky E. M., Pearson H. A., and Dolphin A. C. (1994) Low- and high-voltage-activated calcium channel currents and their modulation in the dorsal root ganglion cell line ND7-23.Neuroscience 58, 539–552.
Koenig H. L., Schumacher M., Ferzaz B., Thi A. N., Ressouches A., Guennoun R., Jung-Testas I., Robel P., Akwa Y., and Baulieu E. E. (1995) Progesterone synthesis and myelin formation by Schwann cells.Science 268, 1500–1503.
Kohama S. G., Garyfallou V. T., and Urbanski H. F. (1998) Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: influence of estradiol.Mol. Brain Res. 53, 328–332.
Koike T., Martin D. P., and Johnson E. M. Jr. (1989) Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.Proc. Natl. Acad. Sci. USA 86, 6421–6425.
Koob G. F. (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathway.Trends Pharmacol. Sci. 13, 177–184.
Kostyuk P., Pronchuck N., Savchenko A., and Verkhratsky A. (1993) Calcium currents in aged rat dorsal root ganglion neurones.J. Physiol. (Lond.) 461, 467–483.
Kubo Y. (1989) Development of ion channels and neurofilaments during neuronal differentiation of mouse embryonic carcinoma cell lines.J. Physiol. (Lond.) 409, 497–523.
Kus L., Handa R., Sanderson, J., Kerr J., and Beitz A. (1995) Distribution of NMDAR1 receptor subunit mRNA and [I125]MK-801 binding in the hypothalamus of intact, castrate and castrate-DHTP treated male rats.Mol. Brain Res. 28, 55–60.
Kyriakis J. M., App H., Zhang X. F., Banerjee P., Brautigan D. L., Rapp U. R., and Avruch J. (1992) Raf-1 activates MAP kinase-kinase.Nature 358, 417–421.
Lasaga M., Duvilauski B. H., Seilicovich A., Afione S., and Debuljuk L (1988) Effect of sex steroids on GABA receptors in the rat hypothalamus and anterior pituitary gland.Eur. J. Pharmacol. 155, 163–166.
Le Greves P., Huang, W., Johansson P., Thornwall M., Zhou Q., and Nyberg F. (1997) Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat.Neurosci. Lett. 226, 61–64.
Lesser S. S. and Lo D. C. (1995) Regulation of voltage-gated ion channels by NGF and ciliary neurotrophic factor in SK-N-SH neuroblastoma cells.J. Neurosci. 15, 253–261.
Lesser S. S., Sherwood N. T., and Lo D. C. (1997) Neurotrophins differentially regulate voltagegated ion channels.Mol. Cell. Neurosci. 10, 173–183.
Levey M. S., Brumwell C. L., Dryer S. E., and Jacob M. H. (1995) Innervation and target tissue interactions differentially regulate acetylcholine receptor subunit mRNA levels in developing neurons in situ.Neuron 14, 153–162.
Levi-Montalcini R. (1987) The nerve growth factor: thirty-five years later.EMBO J. 6, 1145–1154.
Levi-Montalcini R. and Angeletti P. U. (1968) Nerve growth factor.Physiol. Rev. 48, 534–569.
Levine E. S., Dreyfus C. F., Black I. B., and Plummer M. R. (1995) Differential effects of NGF and BDNF on voltage-gated calcium currents in embryonic basal forebrain neurons.J. Neurosci. 15, 3084–3091.
Lewis D. L., de Aizpurua H. J., and Rausch D. M. (1993) Enhanced expression of Ca2+ channels by nerve growth factor and the v-src oncogene in rat phaeochromocytoma cells.J. Physiol. (Lond.) 465, 325–342.
Lindstrom J. (1996) Neuronal nicotinic acetylcholine receptors, inIon Channels, vol. 4 (Toshio N., ed.), Plenum, New York, pp. 377–450.
Lindstrom J. (1997) Nicotinic acetylcholine receptors in health and disease.Mol. Neurobiol. 15, 193–222.
Liu S. J. and Kaczmarek L. K. (1998) The expression of two splice variants of the Kv3.1 potassium channel gene is regulated by different signaling pathways.J. Neurosci. 18, 2881–2890.
Loeb D. M., Maragos J., Martin-Zanca D., Chao M. V., Parada L. F., and Greene L. A. (1991) The trk proto-oncogene resuces NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines.Cell 66, 961–966.
Luine V. N. (1994) Steroid hormone influences on spatial memory.Ann. NY Acad. Sci. 14, 201–211.
Luneau C. J., Williams J. B., Marshall J., Levitan E. S., Oliva C., Smith J. S., Antanavage J., Folander K., Stein R. B., Swanson R., Kaczmarek L. K., and Buhrow S. A. (1991) Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.Proc. Natl. Acad. Sci. USA 88, 3932–3936.
Macdonald R. L., and Angelotti T. P. (1993) Native and recombinant GABAA receptor channels.Cell Physiol. Biochem. 3, 352–373.
Macdonald R. L., and Olsen R. W. (1994) GABAA receptor channels.Ann. Rev. Neurosci. 17, 569–602.
Maconochie D. J. and Knight D. E. (1992) A study of the bovine adrenal chromaffin nicotinic receptor using patch clamp and concentration-jump techniques.J. Physiol. (Lond.) 454, 124–153.
MacVicar B. A. (1984) Voltage-dependent calcium channels in glial cells.Science 226, 1345–1347.
Maggi A. and Perez J. (1986) Estrogen-induced upregulation of γ-aminobutyric acid receptors in the CNS of rodents.J. Neurochem. 47, 1793–1797.
Majewska M. D. (1992) Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance.Prog. Neurobiol. 38, 379–395.
Majewska M. D., Harrison N. L., Schwartz R. D., Barker J. L., and Paul S. M. (1986) Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.Science 232, 1004–1007.
Makara G. B. and Stark E. (1975) Effect of intraventricular glutamate on ACTH release.Neuroendocrinology 18, 213–216.
Mandel G., Cooperman S. S., Maue R. A., Goodman R. H., and Brehm P. (1988) Selective induction of brain type II Na+ channels by nerve growth factor.Proc. Natl. Acad. Sci. USA 85, 924–928.
Mano I. and Teichberg V. I. (1998) A tetrameric subunit stoichiometry for a glutamate receptor-channel complex.NeuroReport 9, 327–331.
Marchionni M. A., Goodearl A. D. J., Chen M. S., Berminghammcdonogh O., Kirk C., Hendricks M., Danehy F., Misumi D., Sudhalter J., Kobayashi K., Wroblewski D., Lynch C., Baldassare M., Hiles I., Davis J. B., Hsuan J. J., Totty N. F., Otsu M., McBurney R. N., Waterfield M. D., Stroobant P., and Gwynne D. (1993) Glial growth factors are alternatively splicedERBB2 ligands expressed in the nervous system.Nature 362, 312–318.
Margiotta J. F., Berg D. K., and Dionne V. E. (1987) Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons.Proc. Natl. Acad. Sci. USA 84, 8155–8159.
Marshall C. J. (1995) Specificity of receptor tyrosine kinase signalling: transient versus sustained extracellular signal-regulated kinase activation.Cell 80, 179–185.
Mascarelli J., Tassin J., and Courtois Y. (1990) Fibroblast growth factor phosphorylation and receptors in rod outer segments. Interaction with glial cells: intracrine and paracrine role in retina.Invest. Ophthalmol. Vis. Sci. 31, 227 (Suppl.).
Matter J. M., Mattersadzinski L., and Ballivet M. (1995) Activity of the beta-3 nicotinic receptor promoter is a marker of neuron fate determination during retina development.J. Neurosci. 15, 5919–5928.
Matter-Sadzinski L., Hernandez M., Roztocil T., Ballivet M., and Matter J. (1992) Neuronal specificity of the α7 nicotinic acetylcholine receptor promoter develops during morphogenesis of the central nervous system.EMBO J. 11, 4529–4538.
Mattson M. P., Kumar K., Cheng B., Wang H., and Michaelis E. K. (1993) Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in cultured hippocampal neurons.J. Neurosci. 13, 4575–4588.
Mattson M. P., Murrain M., Guthrie P. B., and Kater S. B. (1989) Fibroblast growth factor and glutamate: opposing actions in the generation and degeneration of hippocampal neuroarchitecture.J. Neurosci. 9, 3728–3740.
McCobb D. P., Best P. M., and Beam K. G. (1989) Development alters the expression of calcium currents in chick limb motoneurons.Neuron 2, 1633–1643.
McDonough J. and Deneris E. (1997) β43′: an enhancer displaying neural-restricted activity is located in the 3′-ultraslated exon of the rat nicotinic acetylcholine receptor β4 gene.J. Neurosci. 17, 2273–2283.
McEwen B. S. (1991) Steroid hormones are multifunctional messengers to the brain.Trands Endocrinol. Metab. 6, 62–67.
McGehee D. S. and Role L. W. (1995) Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons.Ann. Rev. Physiol. 57, 521–546.
McIntosh L. J., Cortopassi K. M., and Sapolsky R. M. (1998) Glucocorticoids may alter antioxidant enzyme capacity in the brain: kainic acid studies.Brain Res. 791, 215–222.
McKinnon R. D., Matsui T., Dubois-Dalcq M., and Aaronson S. A. (1990) FGF modulates the PDGF-driven pathway of oligodendrocyte development.Neuron 5, 603–614.
Meinecke D. L. and Rakic P. (1990) Developmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum.Dev. Brain Res. 55, 73–86.
Memo M., Bovolin P., Costa E., and Grayson D. R. (1991) Regulation of γ-aminobutyric acidA receptor subunit expression by activation of N-methyl-D-aspartate-selective glutamate receptors.Mol. Pharmacol. 39, 599–603.
Mentis G. Z., Greensmith L., and Vrbova G. (1993) Motoneurons destined to die are rescued by blocking NMDA receptors by MK801.Neuroscience 54, 283–285.
Milton N. G. N., Bessis A., Changeux J-P., and Latchman D. S. (1996) Differential regulation of neuronal nicotinic acetylcholine receptor subunit gene promoters by Brn-3 POU family transcription factors.Biochem. J. 317, 419–423.
Minturn J. E., Southeimer H., Black J. A., Ransom B. R., and Waxman S. G. (1992) Sodium channel expression in optic nerve astrocytes chronically-deprived of axonal contact.Glia 6, 19–29.
Mishina M., Takai T., Imoto K., Noda M., Takahashi T., Numa S., Methfessel C., and Sakmann B. (1986) Molecular distinction between fetal and adult forms of muscle acetylcholine receptor.Nature 321, 406–411.
Montpied P., Weizman A., Weizman R., Kook K. A., Morrow A. L., and Paul S. M. (1993) Repeated swim stress reduces GABAA receptor α subunit mRNAs in the mouse hippocampus.Mol. Brain Res. 18, 267–272.
Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B., and Seeburg P. (1992) Heterodimeric NMDA receptors: molecular and functional distinction of subtypes.Science 256, 1217–1221.
Murrell R. D. and Tolkovsky A. M. (1993) Role of voltage-gated Ca2+ channels and intracellular Ca2+ in rat sympathetic neuron survival and function promoted by high K+ and cyclic AMP in the presence or in the absence of NGF.Eur. J. Neurosci. 5, 1261–1272.
Nair S. M., Werkman T. R., Craig J., Finnell R., Joëls M., and Eberwine J. H. (1998) Corticosteroid regulation of ion channel conductances and mRNA levels in individual hippocampal CA1 neurons.J. Neurosci. 18, 2685–2696.
Newman E. A. (1985) Voltage-dependent calcium and potassium channels in retinal glial cells.Nature 317, 809–811.
Noda M., Ikeda T., Kayano T., Suzuki H., Takeshima H., Kurasaki M., Takahashi H., and Numa S. (1986) Existence of distinct sodium channel messenger RNAs in rat brain.Nature 320, 188–192.
Nooney J. and Lodge M. (1986) The use of invertebrate peptide toxins to establish Ca2+ channel identity of CA3–CA1 neurotransmission in rat hippocampal slices.Eur. J. Pharmacol. 306, 41–50.
Nutter T. J. and Adams D. J. (1991) The permeability of neuronal nicotinic receptor channels to monovalent and divalent inorganic cations.Biophys. J. 59, A34.
O'Connor L. H., Nock B., and McEwen B. S. (1988) Regional specificity of gamma-aminobutyric acid receptor regulation by estradiol.Neuroendocrinology 47, 473–481.
O'Neill E. M., Rebay I., Tijan R., and Rubin G. M. (1994) The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.Cell 78, 137–147.
Opas M., Kalnins V. I., and Fedoroff S. (1986) Spectrin does not redistribute with actin during dbcAMP-induced changes in astrocytes in vitro.Dev. Brain Res. 25, 314–317.
Orchinik M., Weiland N. G., and McEwen B. S. (1994) Adrenalectomy selectively regulates GABAA receptor subunit expression in the hippocampus.Mol. Cell Neurosci. 5, 451–458.
Oyelese A. A., Rizzo M. A., Waxman S. G., and, Kocsis J. D. (1997) Differential effects of NGF and BDNF on axotomy-induced changes in GABAA-receptor-mediated conductance and sodium currents in cutaneous afferent neurons.J. Neurophysiol. 78, 31–42.
Ozaki M., Sasner M., Yano R., Lu H. S., and Buonanno A. (1997) Neuregulin-β induces expression of an NMDA-receptor subunit.Nature 390, 691–694.
Pappas C. A., Ulrich N., and Sontheimer H. (1994) Reduction of glial proliferation by K+ channel blockers is mediated by changes in pHi.NeuroReport 6, 193–196.
Parsons B., Rainbow T. C., MacLusky N. J., and McEwen B. S. (1982) Progestin receptor levels in rat hypothatlamic and limbic nuclei.J. Neurosci. 2, 1446–1452.
Partin K. M., Patneau D. K., Winters C. A., Mayer M. L., and Buonanno A. (1993) Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A.Neuron 11, 1069–1082.
Patchev V. K., Karalis K., and Chrousos G. P. (1994) Effects of excitatory amino acid transmitters on hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) release in vitro: implications in pituitary-adrenal regulation.Brain Res. 633, 312–316.
Patel A. J., Smith R. M., Kingsbury A. E., Hunt A., and Balazs R. (1980) Effects of thyroid state on brain development: muscarinic acetylcholine and GABA receptors.Brain Res. 198, 389–402.
Patwardhan S., Gashler A., Siegel M. G., Chang L. C., Joseph L. J., Shows T. B., Le B. M., and Sukhatme V. P. (1991) EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.Oncogene 6, 917–928.
Paul S. M. and Purdy R. H. (1992) Neuroactive steroids.FASEB J. 6, 2311–2322.
Pelletier G., Liao N., Follea N., and Govindan M. V. (1988) Mapping of estrogen receptor-producing cells in rat brain by in situ hybridization.Neurosci. Lett. 94, 23–28.
Pelligrini-Giampietro D. E., Bennett M. V., and Zukin R. S. (1991) Differential expression of three glutamate receptor genes in developing rat brain: an in situ hybridisation study.Proc. Natl. Acad. Sci. USA 88, 4157–4161.
Perney T. M. and Kaczmarek L. K. (1993) Expression and regulation of mammalian K+ channel genes.Neurosciences 5, 135–145.
Perney T. M., Marshall J., Martin K. A., Hockfield S., and Kaczmarek L. K. (1992) Expression of the mRNAs for the Kv3.1 potassium channel gene in the adult and developing brain.J. Neurophys. 68, 756–766.
Peterson S. L., McCrone S., Coy D., Adelman J. P., and Mahon L. C. (1993a) GABAA receptor subunit mRNAs in cells of the preoptic area: colocalisation with LHRH mRNA using dual-label in situ hybridisation histochemistry.Endocr. J. 1, 29–34.
Peterson S. L., Reeves A., Keller M., Gardoner E., Mahan L. C., and McCrone S. (1993b) Effects of estradiol (E2) and progesterone (P4) on expression of mRNAs encoding GABAA receptor subunits.Soc. Neurosci. Abstr. 19, 489.14
Pettigrew A. G., Crepel F., and Krupa M. (1988) Development of ionic conductances in neurons of the inferior olive in the rat: an vitro study.Proc. R. Soc. Lond. B 234, 199–218.
Piehl F., Arvidsson U., Johnson H., Cullheim S., Dagerlind A., Ulfhake B., Cao Y., Elde R., Pettersson R. F., Terneius L., and Hökfelt T. (1993) GAP-43, aFGF, CCK and α- and β-CGRP, in rat spinal motoneurons subjected to axotomy and/or dorsal root severance.Eur. J. Neurosci. 5 1321–1333.
Piehl F., Tabar G., and Cullheim S. (1995) Expression of NMDA receptor mRNAs in rat motoneurons is down-regulated after axtomy.Eur. J. Neurosci. 7, 2101–2110.
Pollock J. D. and Rane S. G. (1996) p21ras signaling is necessary but not sufficient to mediate neurotrophin induction of calcium channels in PC12 cells.J. Biol. Chem. 271, 8008–8014.
Potthoff O. and Dietzel I. D. (1997) Thyroid hormone regulates Na+ currents in cultured hippocampal neurons from postnatal rats.Proc. R. Soc. Lond. 264, 367–373.
Poulter M. O., Barker J. L., O'Carroll A. M., Lolait S. J., and Mahan L. C. (1992) Differential and transient expression of GABAA receptor α-subunit mRNAs in the developing rat CNS.J. Neurosci. 12, 2888–2900.
Puchalski R. B., Louis J-C., Brose N., Traynelis S. F., Egebjerg J., Kukekov V., Wenthold R. J., Rogers S. W., Lin F., Moran T., Morrison J. H., and Heinemann S. F. (1994) Selective RNA editing and subunit assembly of native glutamate receptors.Neuron 13, 131–147.
Puia G., Santi M. R., Vicini S., Pritchett D., Purdy R. H., Paul S. M., Seeburg P., and Costa E. (1990) Neurosteroids act on recombinant human GABAA receptors.Neuron 4, 759–765.
Puro D. G. and Mano T. (1991) Modulation of calcium channels in human retinal glial cells by basic fibroblast growth factor: a possible role in retinal pathobiology.J. Neurosci. 11, 1873–1880.
Rabow L. E., Russek S. J., and Fabr D. H. (1995) From ion currents to genomic analysis—recent advances in GABAA receptor research.Synapse 21, 189–274.
Raff M. C. (1989) Glial cell diversification in the rat optic nerve.Science 243, 1450–1455.
Randall A. and Tsien R. W. (1995) Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons.J. Neurosci. 15, 2995–3012.
Raucher S. and Dryer S. E. (1995) Target-derived factors regulate the expression of Ca2+-activated K+ currents in developing chick sympathetic neurones.J. Physiol. (Lond.) 486, 605–614.
Ray W. J. and Gottlieb D. I. (1993) Expression of ionotropic glutamate receptor genes by P19 embryonal carcinoma cells.Biochem. Biophys. Res. Comm. 197, 1475–1482.
Ribera A. B. (1990) A potassium channel gene is expressed at neural induction.Neuron 5, 691–701.
Ribera A. B. and Spitzer N. C. (1992) Developmental regulation of potassium channels and the impact on neuronal differentiation, inIon Channels (Narahashi T., ed.), Plenum, New York, pp. 1–38.
Richards J. G., Schoch P., and Haefely W. (1991) Benzodiazepine receptors: new vistas.Sem. Neurosci. 3, 191–203.
Rizzo M. A., Kocsis J. D., and Waxman S. G. (1994) Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity.J. Neurophysiol. 72, 2796–2815.
Rogers S. W., Mandelzys A., Deneris E. S., Cooper E., and Heinemann S. (1992) The expression of nicotinic acetylcholine receptors by PC12 cells treated with NGF.J. Neurosci. 12, 4611–4623.
Role L. and Berg D. K. (1996) Nicotinic receptors in the development and modulation of CNS synapses.Neuron 16, 1077–1085.
Rosemund C., Stern-Bach Y., and Stevens C. F. (1998) The tetrameric structure of a glutamate receptor channel.Science 280, 1596–1599.
Rosen L. B., Ginty D. D., and Greenberg M. E. (1995) Calcium regulation of gene expression.Adv. Second Messenger Phosphoprotein Res. 30, 225–253.
Rothhut B, Romano S. J., Vijayaraghavan S., and Berg D. K. (1996) Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line.J. Neurobiol. 29, 115–125.
Roy M. L. and Narahashi T. (1992) Differential properties of tetrodotoxin-sensitive and terodotoxin-resistant sodium channels in rat dorsal root ganglion neurons.J. Neurosci. 12, 2104–2111.
Rudy B., Kirschenbaum B., Rukenstein A., and Greene L. A. (1987) Nerve growth factor increases the number of functional Na channels and induces TTX-resistant Na channels in PC12 pheochromocytoma cells.J. Neurosci. 7, 1613–1625.
Sah D. W. Y., Ray J., and Gage F. H. (1997) Regulation of voltage- and ligand-gated currents in rat hippocampal progenitor cells in vitro.J. Neurobiol. 32, 95–110.
Sanner C. A., Cunningham T. J., and Goldberger M. E. (1994) NMDA receptor blockade rescues Clarke's and red nucleus neurons after spinal hemisection.J. Neurosci. 14, 6472–6480.
Sapru M. K., Florance S. K., Kirk C., and Goldman D. (1998) Identification of a neuregulin and protein-tyrosine phophatase response element in the nicotinic acetylcholine receptor epsilon subunit gene: regulatory role of an Ets transcription factor.Proc. Natl. Acad. Sci. USA 95, 1289–1294.
Sapru M. K., Zhou G., and Goldman D. (1994) Protein-tyrosine phosphatases specifically regulate muscle adult-type nicotinic acetylcholine receptor gene expression.J. Biol. Chem. 269, 27,811–27,814.
Sarao R., Gupta S. K., Auld V. J., and Dunn R. J. (1991) Developmentally regulated alternative RNA splicing of rat brain sodium channel mRNAs.Nucleic Acid Res. 19, 5673–5679.
Sargent P. B. (1993) The diversity of neuronal nicotinic acetylcholine receptors.Ann. Rev. Neurosci. 16, 403–443.
Schaller K. L., Krzemien D. M., Yarowsky P. J., Krueger B. K., and Caldwell J. H. (1995) A novel abundant sodium channel expressed in neurons and glia.J. Neurosci. 15, 3231–3242.
Schaller K. L., Krzemien, D. M., McKenna N. M., and Caldwell J. H. (1992) Alternatively spliced sodium channel transcripts in brain and muscle.J. Neurosci. 12, 1370–1381.
Schiffer H. H., Swanson G. T., and Heinemann S. F. (1997) Rat GluR7 and a carboxyterminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate.Neuron 19, 1141–1146.
Schlumpf M., Ramseier H., Abriel H., Youmbi M., Baumann J. B., and Lichtensteiger W. (1989) Diazepam effects on the fetus.Neurotoxicology 10, 501–516.
Schmid S. and Guenther E. (1996) Developmental regulation of voltage-activated Na+ and Ca2+ currents in rat retinal ganglion cells.NeuroReport 7, 677–681.
Schoepfer R., Conroy W. G., Whiting P., Gore M., and Lindstrom J. (1990) Brain α-bungarotoxin-binding protein cDNAs and mAbs reveal subtypes of this branch of the ligand-gated ion channel superfamily.Neuron 5, 35–48.
Schuetze S. M. and Role L. W. (1987) Developmental regulation of nicotinic acetylcholine receptors.Ann. Rev. Neurosci. 10, 403–457.
Schwartz A., Palti Y., and Meiri H. (1990) Structural and developmental differences between three types of sodium channels in dorsal root ganglion cells of newborn rats.J. Membr. Biol. 116, 117–128.
Schwartz-Giblin S., Korotzer A., and Pfaff D. W. (1989) Steroid hormone effects on picrotoxin-induced seizures in female and male rats.Brain Res. 476, 240–247.
Seeburg P. H. (1996) The role of RNA editing in controlling glutamate receptor channel properties.J. Neurochem. 66, 1–5.
Seguela P., Wadiche J., Dinnelly-Millet K., Dani J., and Patrick J. (1993) Molecular cloning, functional properties, and distribution of rat brain α7, a nicotinic cation channel highly permeable to calcium.J. Neurosci. 13, 596–604.
Sendtner M., Holtmann B., Kolbeck R., Thoenen H., and Barde Y. A. (1992) Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section.Nature 360, 757–759.
Sendtner M., Kreutzberg G. W., and Thoenen H. (1990) Ciliary neurotrophic factor prevents the degeneration of motoneurons after axotomy.Nature 345, 440,441.
Serafini R., Valeyev A. V., Barker J. L., and Poulter M. O. (1995) Depolarizing GABA-activated Cl− channels in embryonic rat spinal and olfactory bulb cells.J. Physiol. (Lond.) 488, 371–386.
Sharma N., D'Arcangelo G., Kleinklaus A., Halegoua S., and Trimmer J. S. (1993) Nerve growth factor regulates the abundance and distribution of K+ channels in PC12 cells.J. Cell Biol. 123, 1835–1843.
Sheng M., Tsaur M.-L., Jan Y. N., and Jan L. Y. (1992) Subcellular segregation of two A-type K+ channel protein in rat central neurons.Neuron 9, 271–284.
Shitaka Y., Matsuki N., Saito H., and Katsuki H. (1996) Basic fibroblast growth factor increases functional L-type Ca2+ channels in fetal rat hippocampal neurons: implications for neurite morphogenesisin vitro.J. Neurosci. 16, 6476–6489.
Si J., Luo S., and Mei L. (1996) Induction of acetylcholine receptor gene expression by ARIA requires activation of mitogen-activated protein kinase.J. Biol. Chem. 271, 19,752–19,759.
Simerly R. B., Chang C., Muramatsu M., and Swanson L. W. (1990) Distribution of adrogen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridisation study.J. Comp. Neurol. 294, 76–95.
Singh M., Meyer E. M., Millard W. J., and Simpkins J. W. (1994) Ovarian steroid deprivation results in reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.Brain Res. 644, 305–312.
Snider W. D. (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.Cell 77, 627–638.
Snutch T. P., Tomlison W. J., Leonard J. P., and Gilbert S. (1991) Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS.Neuron 7, 45–57.
Sontheimer H. and Ritchie J. M. (1995) Voltage-gated sodium and calcium channels, inNeuroglia (Kettenmann H. and Ransom B. R., eds.), Oxford University Press, New York, pp. 202–220.
Sontheimer H., Black I., and Waxman S. G. (1996) Voltage-gated Na+ channels in glia: properties and possible functions.Trends Neurosci. 19, 325–331.
Sontheimer H., Trotter J., Schachner M., and Kettenmann H. (1989) Channel expression correlates with differentiation stage during the development of oligodendrocytes from their precursor cells in culture.Neuron 2, 1135–1145.
Strübing C., Ahnert-Hilger G., Shan J., Wiedenmann B., Hescheler J., and Wobus A. M. (1995) Differentiation of pluripotent embryonic stem cells into the neuronal lineagein vitro gives rise to mature inhibitory and excitatory neurons.Mech. Dev. 53, 275–287.
Strübing C., Rohwedel J., Ahnert-Hilger G., Wiedenmann B., Hescheler J., and Wobus A. M. (1997) Development of G protein-mediated Ca2+ channel regulation in mouse embryonic stem cell-derived neurons.Eur. J. Neurosci. 9, 824–832.
Sucher N. J., Brose N., Dietcher D. L., Awobuluyi M., Gassic G. P., Bading H., Cepko C. L., Greenberg M. E., Jahn R., Heinemann S. F., and Lipton S. A. (1993) Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells.J. Biol. Chem. 30, 22,299–22,304.
Sun Y. and Zigmond R. (1996) Involvement of leukemia inhibitory factor in the increases in galanin and vasoactive intestinal peptide mRNA and the decreases in neuropeptide Y and tyrosine hydroxylase mRNA after axotomy of sympathetic neurons.J. Neurochem. 67, 1751–1760.
Sun Y., Rao M. S., Zigmond R. E., and Landis S. C. (1994) Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture and after axotomy: the role of cholinergic differentiation factor/leukemia inhibitory factor.J. Neurosci. 25, 415–430.
Swanson G. T., Feldmeyer D., Kaneda M., and Cull-Candy S. G. (1996) Effect of editing and subunit co-assembly on single-channel properties of recombinant kainate receptors.J. Physiol. (Lond.) 492, 129–142.
Swanson R., Marshall J., Smith J. S., Williams J. B., Boyle M. B., Folander K., Luneau C. J., Antanavage J., Oliva C., Buhrow S. A., Bennett D., Stein R. B., and Kaczmarek L. K. (1990) Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain.Neuron 4, 929–939.
Takahashi T. and Momiyama A. (1993) Different types of calcium channels mediate central synaptic transmission.Nature 366, 156–158.
Takimoto K., Fomina A. F., Gealy R., Trimmer J. S., and Levitan E. S. (1993) Dexamethasone rapidly induces Kv1.5 K+ channel gene transcription and expression in clonal pituitary cells.Neuron 11, 359–369.
Takimoto K., Gealy R., Fomina A. F., Trimmer J. S., and Levitan E. S. (1995) Inhibition of voltagegated K+ channel gene expression by the neuropeptide thyrotropin-releasing hormone.J. Neurosci. 15, 449–457.
Tanabe T., Takeshima H., Mikami A., Flockerzi V., Takahashi H., Kangawa K., Kojima M., Matsuo H., Hirose T., and Numa S. (1987) Primary structure of the receptor for calcium channel blockers from skeletal muscle.Nature 328, 313–318.
Tansey M. G., Chu G. C., and Merlie J. P. (1996) ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phophatidylinositol 3-kinase and Ras/MAPK pathway.J. Cell Biol. 134, 465–476.
Tejani-Butt S. M., Yang J., and Kaviani A. (1993) Time course of altered thyroid states on 5-HT1A receptors and 5-HT uptake sites in rat brain: an autoradiographic analysis.Neuroendocrinology 57, 1011–1018.
Thio C. L., Waxman S. G., and Sontheimer H. (1993) Ion channels in spinal cord astrocytes in vitro. III. Modulation of channel expression by co-culture with neurons and neuron-conditioned medium.J. Neurophysiol. 69, 819–831.
Thoenen H. (1995) Neurotrophins and neuronal plasticity.Science 270, 593–598.
Thomas S. M., DeMarco M., D'Arcangelo G., Halegoua S., and Brugge J. S. (1992) Ras is essential for nerve growth factor and phorbol esterinduced tyrosine phosphorylation of MAP kinases.Cell 68, 1031–1040.
Thompson S. M. and Wong R. K. S. (1991) Development of calcium current subtypes in isolated rat hippocampal pyramidal cells.J. Physiol. (Lond.) 439, 671–689.
Thompson C. L., Pollard S., and Stephenson F. A. (1996a) Developmental regulation of expression of GABAA receptor α1 and α6 subunits in cultured rat cerebellar granule cells.Neuropharmacology 35, 1337–1346.
Thompson C. L., Pollard S., and Stephenson F. A. (1996b) Bidirectional regulation of GABAA receptor α1 and α6 subunit expression by a cyclic AMP-mediated signalling mechanism in cerebellar granule cells in primary culture.J. Neurochem. 67, 434–437.
Timpe L. C., and Fantl W. J. (1994) Modulation of a voltage-activated potassium channel by peptide growth factor receptors.J. Neurosci. 14, 1195–1201.
Titmus M. J. and Faber D. S. (1990) Axotomy-induced alterations in the electrophysiological characteristics of neurons.Prog. Neurobiol. 35, 1–51.
Toledo-Aral J. J., Brehm P., Halegoua S., and Mandel G. (1995) A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction.Neuron 14, 607–611.
Toledo-Aral J. J., Moss B. L., He Z.-J., Koszowski A. G., Whisenand T., Levinson S. R., Wolf J. J., Silos-Santiago I., Halegoua S., and Mandel G. (1997) Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons.Proc. Natl. Acad. Sci. USA 94, 1527–1532.
Tolle T. R., Berthele A., Zieglgansberger W., Seeburg P. H., and Wisden W. (1994) The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray.J. Neurosci. 13, 5009–5028.
Trapp T., Rupprecht R., Castren M., Reul J. M. H. M., and Holsboer F. (1994) Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.Neuron 13, 1457–1462.
Traverse S., Gomez N., Paterson H., Marshall C., and Cohen P. (1992) Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells.Biochem. J. 288, 351–355.
Traverse S., Seedorf K., Paterson H., Marshall C., Cohen P., and Ulrich A. (1994) EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.Curr. Biol. 4, 694–701.
Treier M., Bohmann D., and Mlodzik M. (1995) Jun cooperates with the ETS domain proteinPOINTED to induce photoreceptor R7 fate in the Drosophila eye.Cell 83, 753–760.
Trimmer J. S. (1993) Expression of Kv2.1 delayed rectifier K+ channel isoforms in the developing rat brain.FEBS Lett. 324, 205–210.
Tsien R. W., Ellinor P. T., and Horne W. A. (1991) Molecular diversity of voltage-dependent Ca2+ channels.Trends Pharmacol. Sci. 12, 349–354.
Tsien R. W., Lipscombe D., Madison D. V., Bley K. R., and Fox A. P. (1988) Multiple types of neuronal calcium channels and their selective modulation.Trends Neurosci. 11, 431–438.
Urbano F. J., Sierra F., Colombo J. A., Velasco J. M., and Buno W. (1997) Different voltage-gated sodium currents are expressed by human neuroblastoma NB69 cells when cultured in defined serum-free and in astroglial-conditioned media.Glia 19, 161–170.
Usowicz M. M., Porzig H., Becker C., and Reuter H. (1990) Differential expression by nerve growth factor of two types of Ca2+ channels in rat phaeochromocytoma cell lines.J. Physiol. 426, 95–116.
Valenzuela C. F., Kazlaukas A., Brozowski S. J., Weiner J. L., Demali K. A., McDonald B. J., Moss S. J., Dunwiddie T. V., and Harris R. A. (1995) Platelet-derived growth factor receptor is a novel modulator of type A γ-aminobutyric acid-gated ion channels.Mol. Pharmacol. 48, 1099–1107.
Valenzuela C. F., Kazlauskas A., and Weiner J. L. (1997) Roles of platelet-derived growth factor in the developing and mature nervous systems.Brain Res. Rev. 24, 77–89.
Van der Greer P. and Hunter T. (1994) Receptor protein tyrosine kinases and their signal transduction pathways.Ann. Rev. Cell Biol. 10, 251–337.
Vejsada R., Tseng J. L., Lindsay R. M., Acheson A., Aebischer P., and Kato A. C. (1998) Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons.Neuroscience 84, 129–139.
Verkhratsky A. and Kettenmann H. (1996) Calcium signaling in glial cells.Trends Neurosci. 19, 346–352.
Vescovi A. L., Reynolds B. A., Fraser D. D., and Weiss S. (1993) bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.Neuron 11, 951–966.
Walker D. and De Waard M. (1998) Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function.Trends Neurosci. 21, 148–154.
Wall P. D. and Devor M. (1981) The effect of peripheral nerve injury on dorsal root potentials and on transmission of afferent signals into the spinal cord.Brain Res. 209, 95–111.
Wan Q., Xiong Z. Q., Man H. Y., Ackerley C. A., Braunton J., Lu W. Y., Becker L. E., MacDonald J. F., and Wang Y. T. (1997) Recruitment of functional GABAA receptors to postsynaptic domains by insulin.Nature 388, 686–690.
Watanabe M., Inoue Y., Sakimura K., and Mishina M. (1992) Developmental changes in distribution of NMDA receptor channel subunit mRNAs.NeuroReport 3, 1138–1140.
Waxman S. G., Kocsis J. D., and Black J. A. (1994) Type III sodium channel mRNA is expressed in embryonic but not in adult spinal sensory neurons, and is reexpressed following axotomy.J. Neurophysiol. 72, 466–470.
Wehling M. (1997) Specific, nongenomic actions of steroid hormones.Ann. Rev. Physiol. 59, 365–393.
Weiland N. G. (1992) Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus.Endocrinology 131, 662–668.
Weiland N. G., Orchinik M., and Tanapat P. (1997) Chronic corticosterone treatment induces parallel changes in N-methyl-D-aspartate receptor subunit messenger RNA levels and antagonist binding sites in the hippocampus.Neuroscience 78, 653–662.
Weiland N. G. and Orchinik M. (1995) Specific subunit mRNAs of the GABAA receptor are regulated by progesterone in subfields of the hippocampus.Mol. Brain Res. 32, 271–278.
Wenthold R. J., Yokotani N., Doi K., and Wada K. (1992) Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies: evidence for a heterooligomeric structure in rat brain.J. Biol. Chem. 267, 501–507.
Wheeler D., Randall A., and Tsien R. (1994) Roles of N-type and Q-type Ca2+ channels in supporting synaptic transmission.Science 264, 107–111.
Whiting P. and Lindstrom J. (1988) Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies.J. Neurosci. 8, 3395–3404.
Whiting P. J., Schoepfer R., Swanson L. W., Simmons D. M., and Lindstrom J. M. (1987) Functional acetylcholine receptor in PC12 cells reacts with a monoclonal antibody to brain nicotinic receptors.Nature 327, 515–518.
Wiedehage J., Schmidtmayer J., and Buse E. (1992) Development of membrane currents in mammalian neuroventricular cells from the early neural tube stagein vitro: aspects of the neuronal lineage.Int. J. Dev. Neurosci. 10, 375–385.
Williams K. (1994) Subunit-specific potentiation of recombinant N-methyl-D-aspartate receptors by histamine.Mol. Pharmacol. 46, 531–541.
Williams K., Zappia A. M., Pritchett D. B., Chen Y. M., and Molinoff P. B. (1994) Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits.Mol. Pharmacol. 45, 803–809.
Wilson G. F. and Chiu S. Y. (1990) Regulation of potassium channels in Schwann cells during early developmental myelinogenesis.J. Neurosci. 10, 1615–1625.
Wisden W., Laurie D. J., Monyer H., and Seeburg P. H. (1992) The distribution of 13 GABAA receptor subunit mRNAs in the rat brain I. Telencephalon, diencephalon, mesencephalon.J. Neurosci. 12, 1040–1062.
Wissenbach U., Bosse-Doenecke E., Freise D., Ludwig A., Murakami M., Hofmann F., and Flockerzi V. (1998) The structure of the murine calcium channel gamma-subunit gene and protein.J. Biol. Chem. 379, 45–50.
Witcher D. R., Dewaard M., Sakamoto J., Franzini-Armstrong C., Pragnell M., Kahl S. D., and Campbell K. P. (1993) Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain.Science 261, 486–489.
Witzemann V., Stein E., Barg B., Konno T., Koenen M., Kues W., Criado M., Hofmann M., and Sakmann B. (1990) Primary structure and functional expression of the α, β, γ, δ and ε subunits of the acetylcholine receptor from rat muscle.Eur. J. Biochem. 194, 347–448.
Wood K. W., Sarnecki C., Roberts T. M., and Blenis J. (1992) Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinases, Raf-1, and RSK.Cell 68, 1041–1050.
Wu R.-L. and Barish M. E. (1994) Astroglial modulation of transient potassium current development in cultured mouse hippocampal neurons.J. Neurosci. 14, 1677–1687.
Yan Q., Elliott J., and Snider W. D. (1992) Brainderived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death.Nature 360, 753–755.
Yang X., Fyodorov D., and Deneris E. S. (1995) Transcriptional analysis of acetylcholine receptor alpha 3 gene promoter motifs that bind Sp1 and AP2.J. Biol. Chem. 270, 8514–8520.
Yang X., McDonough J., Fyodorov D., Morris M., Wang F., and Deneris E. S. (1994) Characterization of an acetylcholine receptor alpha 3 gene promoter and its activation by the POU domain factor SCIP/Tst-1.J. Biol. Chem. 269, 10,252–10,264.
Yang X., Yang F., Fyodorov D., Wang F., McDonough J., Herrup K., and Deneris E. (1997) Elements between the protein-coding regions of the adjacent β4 and α3 acetylcholine receptor genes direct neuron-specific expression in the central nervous system.J. Neurobiol. 32, 311–324.
Yarowsky P. J., Krueger B. K., Olson C. E., Clevinger E. C., and Koos R. D. (1991) Brain and heart sodium channel subtype mRNA expression in rat cerebral cortex.Proc. Natl. Acad. Sci. USA 88, 9453–9457.
Yu R. and Ticku M. K. (1995a) Chronic neurosteroid treatment produces functional heterologous uncoupling at the GABAA-benzodiazepine receptor complex in mammalian cortical neurons.Mol. Pharmacol. 47, 603–610.
Yu R. and Ticku M. K. (1995b) Chronic neurosteroid treatment decreases the efficacy of benzodiazepine ligands and neurosteroids at the GABAA receptor complex in mammalian cortical neurons.J. Pharmacol. Exp. Ther. 275, 784–789.
Yu R. Hay M., and Ticku M. K. (1996a) Chronic neurosteroid treatment attenuates single cell GABA(A) response and its potentiation by modulators in cortical neurons.Brain Res. 706, 160–162.
Yu R., Follesa P., and Ticku M. K. (1996b) Downregulation of the GABA receptor subunits mRNA levels in mammalian cultured cortical neurons following chronic neurosteroid treatment.Mol. Brain. Res. 41, 163–168.
Zhang L., Zheng X., Paupard M.-C., Wang A. P., Santchi L., Friedman L. K., Zukin R. S., and Bennett M. V. L. (1994) Spermine potentiation of recombinant N-methyl-D-aspartate receptors is affected by subunit composition.Proc. Natl. Acad. Sci. USA 91, 10,883–10,887.
Zhou Y., Deneris E., and Zigmond R. E. (1998) Differential regulation of levels of nicotinic receptor subunit transcripts in adult sympathetic neurons after axotomy.J. Neurobiol. 34, 164–178.
Zhu X. J., Lai C., Thomas S., and Burden S. J. (1995) Neuregulin receptors,ERBB3 andERBB4, are localized at neuromuscular synapses.EMBO J. 14, 5842–5848.
Zoli M., LeNovere N., Hill J. A. Jr., and Changeux J.-P. (1995) Developmental regulation of nicotinic acetylcholine receptor subunit mRNAs in the rat central and peripheral nervous systems.J. Neurosci. 15, 1912–1939.
Zur K. B., Oh Y., Waxman S. G., and Black J. A. (1995) Differential up-regulation of sodium channel α- and β1-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF.Mol. Brain Res. 30, 97–103.
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Chew, LJ., Gallo, V. Regulation of ion channel expression in neural cells by hormones and growth factors. Mol Neurobiol 18, 175–225 (1998). https://doi.org/10.1007/BF02741300
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DOI: https://doi.org/10.1007/BF02741300