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Leukotrien A4 hydrolase and the committed step in leukotriene B4 biosynthesis

  • Basic Sciences
  • The Immunobiology of Leukotriene Inhibitors
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References

  1. Samuelsson B. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation. Science 1983;220:568–575.

    Article  PubMed  CAS  Google Scholar 

  2. Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. New Engl J Med 1990;323:645–655.

    Article  PubMed  CAS  Google Scholar 

  3. Borgeat P, Samuelsson B. Arachidonic acid metabolism in polymorphonuclear leukocytes: Unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci USA 1979;76:32,133–32,217.

    Google Scholar 

  4. Serhan CN, Haeggstrom JZ, Leslie CC. Lipid mediator networks in cells signaling—update and impact of cytokines. FASEB J 1996;10:1147–1158.

    PubMed  CAS  Google Scholar 

  5. Haeggstrom J, Radmark O, Fitzpatrick FA. Leukotriene A4-hydrolase activity in guinea pig and human liver. Biochim Biophys Acta 1985;835:378–384.

    PubMed  CAS  Google Scholar 

  6. Samuelsson B, Funk CD. Enzymes involved in the biosynthesis of leukotriene B4. J Biol Chem 1989;264:19,469–19,472.

    CAS  Google Scholar 

  7. Stromberg F, Hamberg M, Rosenqvist U, Dahlen S-E, Haeggstrom JZ. Formation of a novel metabolite of leukotriene A4 in tissues of Xenopus laevis. Eur J Biochem 1996;238:599–605.

    Article  PubMed  CAS  Google Scholar 

  8. Williams JD, Czop JK, Austen KF. Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. J Immunol 1984;132:3034–3040.

    PubMed  CAS  Google Scholar 

  9. Odlander B, Jakobsson P-J, Rosen A, Claesson H-E. Human B and T lymphocytes convert leukotriene A4 into leukotriene B4. Biochem Biophys Res Commun 1988;153:203–208.

    Article  PubMed  CAS  Google Scholar 

  10. Fitzpatrick FA, Ligget W, McGee J, Bunting S, Morton D, Samuelsson B. Metabolism of leukotriene A4 by human erythrocytes. A novel cellular source of leukotriene B4. J Biol Chem 1984;259:11,403–11,407.

    CAS  Google Scholar 

  11. Weller PF, Lee CW, Foster DW, Corey EJ, Austen KF, Lewis RA. Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: Predominant production of leukotriene C4. Proc Natl Acad Sci USA 1983;80: 7626–7630.

    Article  PubMed  CAS  Google Scholar 

  12. Shaw RJ, Crowell O, Kay AB. Preferential generation of leukotriene C4 by human eosinophils. Clin Exp Immunol 1984;56:716–722.

    PubMed  CAS  Google Scholar 

  13. Warner JA, Freeland HS, MacGlashan Jr DW, Lichtenstein LM, Peters SP. Purified human basophils do not generate LTB4. Biochem Pharmacol 1987;36:3195–3199.

    Article  PubMed  CAS  Google Scholar 

  14. Bigby TD, Lee DM, Meslier N, Gruenert DC. Leukotriene A4 hydrolase activity of human airway epithelial cells. Biochem Biophys Res Commun 1989;164:1–7.

    Article  PubMed  CAS  Google Scholar 

  15. Brown GP, Monick MM, Hunninghake GW. Human alveolar macrophage arachidonic acid metabolism. Am J Physiol 1988;254:C809-C815.

    PubMed  CAS  Google Scholar 

  16. Peters SP, MacGlashan Jr DW, Schulman ES, Schleimer RP, Hayes EC, Rokach J, Adkinson Jr NF, Lichtenstein LM. Arachidonic acid metabolism in purified human lung mast cells. J Immunol 1984;132:1972–1979.

    PubMed  CAS  Google Scholar 

  17. Freeland HS, Schleimer RP, Schulman ES, Lichtenstein LM, Peters SP. Generation of leukotriene B4 by lung fragments and purlfied human lung mast cells. Am Rev Respir Dis 1988;138:389–394.

    PubMed  CAS  Google Scholar 

  18. Gut J, Goldman DW, Jamieson GC, Trudell JR. Conversion of leukotriene A4 to leukotriene B4: Catalysis by human liver microsomes under anaerobic conditions. Arch Biochem Biophys 1987;259:497–509.

    Article  PubMed  CAS  Google Scholar 

  19. Haeggstrom JZ. Leukotriene A4 hydrolase. In Drazen JM, Dahlen S.-E, Lee T (eds). Lung biology in health and disease, 5-lipoxygenase products in asthma. New York, Marcel Dekker, 1998, pp. 51–76.

    Google Scholar 

  20. Evans JF, Nathaniel DJ, Zamboni RJ, Ford-Hutchinson AW. Leukotriene A3: A poor substrate but a potent inhibitor of rat and human neutrophil leukotriene A4 hydrolase. J Biol Chem 1985;260:10,966–10,970.

    CAS  Google Scholar 

  21. Nathaniel DJ, Evans JF, Leblanc Y, Leveille C, Fitzsimmons B, Ford-Hutchinson AW. Leukotriene As is a substrate and inhibitor of rat and human neutrophil LTA4 hydrolase. Biochem Biophys Res Commun 1985;131:827–835.

    Article  PubMed  CAS  Google Scholar 

  22. Ohishi N, Izumi T, Minami M, Kitamura S, Seyama Y, Ohkawa S, Terao S, Yotsumoto H, Takaku F, Shimizu T. Leukotriene A4 hydrolase in the human lung: Inactivation of the enzyme with leukotriene A4 isomers. J Biol Chem 1987;262:10,200–10,205.

    CAS  Google Scholar 

  23. McGee J, Fitzpatrick F. Enzymatic hydration of leukotriene A4: Purification and characterization of a novel epoxide hydrolase from human erythrocytes. J Biol Chem 1985;260:12,832–12,837.

    CAS  Google Scholar 

  24. Rybina IV, Liu H, Gor Y, Feinmark SJ. Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation. J Biol Chem 1997;272:31,865–31,871.

    Article  CAS  Google Scholar 

  25. Funk CD, Radmark O, Fu JY, Matsumoto T, Jornvall H, Shimizu T, Samuelsson B. Molecular cloning and amino acid sequence of leukotriene A4 hydrolase. Proc Natl Acad Sci USA 1987;84:6677–6681.

    Article  PubMed  CAS  Google Scholar 

  26. Minami M, Ohno S, Kawasaki H, Radmark O, Samuelsson B, Jornvall H, Shimizu T, Seyama Y, Suzuki K. Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. J Biol Chem 1987;262:13,873–13,876.

    CAS  Google Scholar 

  27. Medina JF, Radmark O, Funk CD, Haeggstrom JZ. Molecular cloning and expression of mouse leukotriene A4 hydrolase cDNA. Biochem Biophys Res Commun 1991;176:1516–1524.

    Article  PubMed  CAS  Google Scholar 

  28. Makita N, Funk CD, Imai E, Hoover RL, Badr KF. Molecular cloning and functional expression of rat leukotriene A4 hydrolase using the polymerase chain reaction. FEBS Lett 1992;299:273–277.

    Article  PubMed  CAS  Google Scholar 

  29. Minami M, Mutoh H, Ohishi N, Honda ZI, Bito H, Shimizu T. Amino-acid sequence and tissue distribution of guinea-pig leukotriene A4 hydrolase. Gene 1995;161:249–251.

    Article  PubMed  CAS  Google Scholar 

  30. Mancini JA, Evans JF. Cloning and characterization of the human leukotriene A4 hydrolase gene. Eur J Biochem 1995;231:65–71.

    Article  PubMed  CAS  Google Scholar 

  31. Malfroy B, Kado-Fong H, Gros C, Giros B, Schwartz J-C, Hellmiss R. Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: A member of a super family of zinc-metallohydrolases. Biochem Biophys Res Commun 1989;161:236–241.

    Article  PubMed  CAS  Google Scholar 

  32. Vallee BL, Auld DS. Zinc coordination, function, and structure of zinc enzymes and other proteins. Biochemistry 1990;29:5647–5659.

    Article  PubMed  CAS  Google Scholar 

  33. Haeggstrom JZ, Wetterholm A, Shapiro R, Vallee BL, Samuelsson B. Leukotriene A4 hydrolase: a zinc metalloenzyme. Biochem Biophys Res Commun 1990;172:965–970.

    Article  PubMed  CAS  Google Scholar 

  34. Haeggstrom JZ, Wetterholm A, Vallee BL, Samuelsson B. Leukotriene A4 hydrolase: An epoxide hydrolase with peptidase activity. Biochem Biophys Res Commun 1990;173:431–437.

    Article  PubMed  CAS  Google Scholar 

  35. Minami M, Ohishi N, Mutoh H, Izumi T, Bito H, Wada H, Seyama Y, Toh H, Shimizu T. Leukotriene A4 hydrolase is a zinc-containing aminopeptidase. Biochem Biophys Res Commun 1990;173:620–626.

    Article  PubMed  CAS  Google Scholar 

  36. Wu Q, Lahti JM, Air GM, Burrows PD, Cooper MD. Molecular cloning of the murine BP1/6C3 antigen: A member of the zinc-dependent metallopeptidase family. Proc Natl Acad Sci USA 1990;87:993–997.

    Article  PubMed  CAS  Google Scholar 

  37. Menard A, Mock M, Montecucco C. Similarities between the lethal factor of bacillus anthracis and leukotriene A4 hydrolase. Mol Microbiol 1995;18:991, 992.

    Article  CAS  Google Scholar 

  38. NC-IUBMB (Nomenclature Committee of the International Union of Biochemistry and Molecular Biology) Enzyme nomenclature. Recommendations 1992, Suppl. 3. Eur J Biochem 1996;237:1–5.

    Article  Google Scholar 

  39. Fukasawa KM, Fukasawa K, Kanai M, Fujii S, Harada M. Molecular cloning and expression of rat liver aminopeptidase B. J Biol Chem 1996;271:30,731–30,735.

    Article  CAS  Google Scholar 

  40. Cadel S, Foulon T, Viron A, Balogh A, Midol-Monnet S, Noel N, Cohen P. Aminopeptidase B from the rat testis is a bifunctional enzyme structurally related to leukotriene A4 hydrolase. Proc Natl Acad Sci USA 1997;94:2963–2968.

    Article  PubMed  CAS  Google Scholar 

  41. Nasr F, Becam AM, Herbert CJ. The sequence of 12.8 kb from the left arm of chromosome XIV reveals a sigma element, a pro-tRNA and six complete open reading frames, one of which encodes a protein similar to the human leukotriene A4 hydrolase. Yeast 1996;12:493–499.

    Article  PubMed  CAS  Google Scholar 

  42. Wetterholm A, Haeggstrom JZ. Leukotriene A4 hydrolase: an anion activated peptidase. Biochim Biophys Acta 1992;1123:275–281.

    PubMed  CAS  Google Scholar 

  43. Fitzpatrick FA, Haeggstrom J, Granstrom E, Samuelsson B. Metabolism of leukotriene A4 by an enzyme in blood plasma: A possible leukotactic mechanism. Proc Natl Acad Sci USA 1983;80:5425–5429.

    Article  PubMed  CAS  Google Scholar 

  44. Munafo DA, Shindo K, Baker JR, Bigby TD. Leukotriene A4 hydrolase in human bronchoalveolar ravage fluid. J Clin Invest 1994;93:1042–1050.

    Article  PubMed  CAS  Google Scholar 

  45. Orning L, Fitzpatrick FA. Albumins activate peptide hydrolysis by the bifunctional enzyme LTA4 hydrolase/aminopeptidase. Biochemistry 1992;31:4218–4223.

    Article  PubMed  CAS  Google Scholar 

  46. Orning L, Gierse JK, Fitzpatrick FA. The bifunctional enzyme leukotriene A4 hydrolase an arginine aminopeptidase of high efficiency and specificity. J Biol Chem 1994;269:11,269–11,273.

    CAS  Google Scholar 

  47. Griffin KJ, Gierse J, Krivi G, Fitzpatrick FA. Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase. Prostaglandins 1992;44:251–257.

    Article  PubMed  CAS  Google Scholar 

  48. Nissen JB, Iversen L, Kragballe K. Characterization of the aminopeptidase activity of epidermal leukotriene A4 hydrolase against the opioid dynorphin fragment 1–7. Br J Dermatol 1995;133:742–749.

    Article  PubMed  CAS  Google Scholar 

  49. MacLouf J, Fitzpatrick FA, Murphy RC. Transcellular biosynthesis of eicosanoids. Pharmacol Res 1989;21:1–7.

    Article  PubMed  CAS  Google Scholar 

  50. Claesson H-E, Haeggstrom J. Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4. Eur J Biochem 1988;173:93–100.

    Article  PubMed  CAS  Google Scholar 

  51. Medina JF, Barrios C, Funk CD, Larsson O, Haeggstrom J, Radmark O. Human fibroblasts show expression of the leukotriene A4 hydrolase gene, which is increased after SV-40 transformation. Eur J Biochem 1990;191:27–31.

    Article  PubMed  CAS  Google Scholar 

  52. Iversen L. The role of leukotriene A4 hydrolase/aminopeptidase in transcellular leukotriene B4 synthesis in human epidermis. Acta Derm Venereol 1997;Suppl.199.

  53. Brady HR, Serhan CN. Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions—inhibition by antibodies against CD18 and L-selectin. Biochem Biophys Res Commun 1992;186:1307–1314.

    Article  PubMed  CAS  Google Scholar 

  54. Zhou SY, Stark JM, Leikauf GD. Leukotriene B4 formation—human neutrophil airway epithelial cell interactions. J Appl Physiol 1995;78:1396–1403.

    PubMed  CAS  Google Scholar 

  55. Grimminger F, Sibelius U, Seeger W. Amplification of LTB4 generation in AM-PMN cocultures—transcellular 5-lipoxygenase metabolism. Am J Physiol 1991;261:L195-L203.

    PubMed  CAS  Google Scholar 

  56. Medina JF, Wetterholm A, Radmark O, Shapiro R, Haeggstrom JZ, Vallee BL, Samuelsson B. Leukotriene A4 hydrolase: Determination of the three zincbinding ligands by site-directed mutagenesis and zinc analysis. Proc Natl Acad Sci USA 1991;88:7620–7624.

    Article  PubMed  CAS  Google Scholar 

  57. Wetterholm A, Medina JF, Radmark O, Shapiro R, Haeggstrom JZ, Vallee BL, Samuelsson B. Leukotriene A4 hydrolase: Abrogation of the peptidase activity by mutation of glutamic acid-296. Proc Natl Acad Sci USA 1992;89:9141–9145.

    Article  PubMed  CAS  Google Scholar 

  58. Watt VM, Yip CC. Amino acid sequence deduced from a rat kidney cDNA suggests it encodes the Zn-peptidase Aminopeptidase N. J Biol Chem 1989;264:5480–5487.

    PubMed  CAS  Google Scholar 

  59. Minami M, Bito H, Ohishi N, Tsuge H, Miyano M, Mori M, Mori M, Wada H, Mutoh H, Shimada S, Izumi T, Abe K, Shimizu T. Leukotriene A4 hydrolase, a bifunctional enzyme. Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site-directed mutagenesis at Glu-297. FEBS Lett 1992;309:353–357.

    Article  PubMed  CAS  Google Scholar 

  60. Blomster M, Wetterholm A, Mueller MJ, Haeggstrom JZ. Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase. Eur J Biochem 1995;231:528–534.

    Article  PubMed  CAS  Google Scholar 

  61. Pangburn MK, Walsh KA. Thermolysin and neutral protease: Mechanistic considerations. Biochemistry 1975;14:4050–4054.

    Article  CAS  Google Scholar 

  62. Kester WR, Matthews BW. Crystallographic, study of the binding of dipeptide inhibitors to thermolysin: Implications for the mechanism of catalysis. Biochemistry 1977;16:2506–2516.

    Article  PubMed  CAS  Google Scholar 

  63. Orning L, Jones DA, Fitzpatrick FA. Mechanism-based inactivation of leukotriene A4 hydrolase during leukotriene B4 formation by human erythrocytes. J Biol Chem 1990;265:14,911–14,916.

    CAS  Google Scholar 

  64. Orning L, Gierse J, Duffin K, Bild G, Krivi G, Fitzpatrick FA. Mechanism-based inactivation of leukotriene A4 hydrolase/aminopeptidase by leukotriene A4. Mass spectrometric and kinetic characterization. J Biol Chem 1992;267:22,733–22,739.

    CAS  Google Scholar 

  65. Mueller MJ, Wetterholm A, Blomster M, Jornvall H, Samuelsson B, Haeggstrom JZ. Leukotriene A4 hydrolase: Mapping of a heneicosapeptide involved in mechanism-based inactivation. Proc Natl Acad Sci USA 1995;92:8383–8387.

    Article  PubMed  CAS  Google Scholar 

  66. Mueller, MJ, Blomster, M, Opperman UCT, Jornvall H, Samuelsson B, Haeggstrom JZ, Leukotriene A4 hydrolase: Protection from mechanism-based inactivation by mutation of tyrosine-378. Proc Natl Acad Sci USA 1996;93:5931–5935.

    Article  PubMed  CAS  Google Scholar 

  67. Mueller MJ, Blomster M, Samuelsson B, Haeggstrom JZ Leukotriene A4 hydrolase: mutation of tyrosine-383 allows conversion of leukotriene A4 into an isomer of leukotriene B4. J Biol Chem 1996;271:24,345–24,348.

    CAS  Google Scholar 

  68. Tsuge H, Ago H, Aoki M, Furuno M, Noma M, Miyano M, Minami M, Izumi T, Shimizu T. Crystallization and preliminary X-ray crystallographic studies of recombinant human leukotriene A4 hydrolase complexed with bestatin. J Mol Biol 1994;238:854–856.

    Article  PubMed  CAS  Google Scholar 

  69. Odlander B, Claesson H-E, Bergman T, Radmark O, Jornvall H, Haeggstrom JZ. Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: Indications of catalytically divergent forms of the enzyme. Arch Biochem Biophys 1991;287:167–174.

    Article  PubMed  CAS  Google Scholar 

  70. Haeggstrom J, Bergman T, Jornvall H, Radmark O. Guinea-pig liver leukotriene A4 hydrolase: Purification, characterization and structural properties. Eur J Biochem 1988;174:717–724.

    Article  PubMed  CAS  Google Scholar 

  71. Bito H, Ohishi N, Miki I, Minami M, Tanabe T, Shimizu T, Seyama Y. Leukotriene A4 hydrolase from guinea pig lung: The presence of two catalytically active forms. J Biochem 1989;105:261–264.

    PubMed  CAS  Google Scholar 

  72. Bigby TD, Lee DM, Minami M, Ohishi N, Shimizu T, Baker JR. Characterization of human airway epithelial cell leukotriene A4 hydrolase. Am J Respir Cell Mol Biol 1994;11:615–624.

    PubMed  CAS  Google Scholar 

  73. Baker JR, Kylstra TA, Bigby TD. Effects of metalloproteinase inhibitors on leukotriene A4 hydrolase in human airway epithelial cells. Biochem Pharmacol 1995;50:905–912.

    Article  PubMed  CAS  Google Scholar 

  74. Radmark O, Haeggstrom J. Properties of leukotriene A4 hydrolase. Adv Prostaglandin, Leukotriene Thromboxane Res 1990;20:35–45.

    CAS  Google Scholar 

  75. Jendraschak E, Kaminski WE, Kiefl R, von Schacky C. The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms. Biochem J 1996;314:733–737.

    PubMed  CAS  Google Scholar 

  76. Orning L, Krivi G, Fitzpatrick FA: Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes. J Biol Chem 1991;266:1375–1378.

    PubMed  CAS  Google Scholar 

  77. Orning L, Krivi G, Bild G, Gierse J, Aykent S, Fitzpatrick FA. Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril. J Biol Chem 1991;266:16,507–16,511.

    CAS  Google Scholar 

  78. Yuan W, Zhong Z, Wong CH, Haeggstrom JZ, Wetterholm A, Samuelsson B. Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity. Bioorg Med Chem Lett 1991;1:551–556.

    Article  CAS  Google Scholar 

  79. Yuan W, Wong C-H, Haeggstrom JZ, Wetterholm A, Samuelsson B. Novel tight-binding inhibitors of leukotriene A4 hydrolase. J Am Chem Soc 1992;114:6552–6553.

    Article  CAS  Google Scholar 

  80. Yuan W, Munoz B, Wong C-H, Haeggstrom JZ, Wetterholm A, Samuelsson B. Development of selective tight-binding inhibitors of leukotriene A4 hydrolase. J Med Chem 1993;36:211–220.

    Article  PubMed  CAS  Google Scholar 

  81. Wetterholm A, Haeggstrom JZ, Samuelsson B, Yuan W, Munoz B, Wong C-H. Potent and selective inhibitors of leukotriene A4 hydrolase: Effects on purified enzyme and human polymorphonuclear leukocytes. J Pharmacol Exp Ther 1995;275:31–37.

    PubMed  CAS  Google Scholar 

  82. Hogg JH, Ollmann IR, Haeggstrom JZ, Wetterholm A, Samuelsson B, Wong C-H. Amino hydroxamic acids as potent inhibitors of LTA4 hydrolase. Bioorg Med Chem 1995;3:1405–1415.

    Article  PubMed  CAS  Google Scholar 

  83. Yuan JH, Birkmeier J, Yang DC, Hribar JD, Liu N, Bible R, Hajdu E, Rock M, Schoenhard G. Isolation and identification of metabolites of leukotriene A4 hydrolase inhibitor SC57461 in rats. Drug Metab Dispos 1996;24:1124–1133.

    PubMed  CAS  Google Scholar 

  84. Smith WG, Russell MA, Liang C, Askonas LA, Kachur JF, Kim S, Souresrafil N, Price DV, Clapp NK. Pharmacological characterization of selective inhibitors of leukotriene A4 hydrolase. Prostaglandins Leukot Essent Fatty Acids 1996:55(Suppl 1):13.

    Google Scholar 

  85. Yokomizo T, Izumi T, Chang K, Takuwa Y, Shimizu T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 1997;387:620–624.

    Article  PubMed  CAS  Google Scholar 

  86. Owman C, Nilsson C, Lolait SJ. Cloning of cDNA encoding a putative chemoattractant receptor. Genomics 1996;37:187–194.

    Article  PubMed  CAS  Google Scholar 

  87. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPARα leukotriene B4 pathway to inflammation control. Nature 1996;384:39–43.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Medical Biochemsitry and Biophysics, Division of Chemistry II, Karolinska Institutet, S-171 77, Stockholm, Sweden

    Jesper Z. Haeggström

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Haeggström, J.Z. Leukotrien A4 hydrolase and the committed step in leukotriene B4 biosynthesis. Clinic Rev Allerg Immunol 17, 111–131 (1999). https://doi.org/10.1007/BF02737600

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