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Diabetes mellitus, serum urate and gout. A study in 314 patients

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Riassunto

La somiglianza chimica esistente tra acido urico ed allossana ha indotto l’A. ad eseguire determinazioni dell’uricemia in 314 soggetti diabetici. Solo un paziente era affetto da gotta, mentre la malattia non figurava nell’anamnesi familiare di nessuno di essi. Il valore medio dell’uricemia era di 4,8 mg/100 ml (SD ± 1,57) negli uomini e di 4,2 mg/100 ml (SD ± 1,59) nelle donne. Nei primi, i livelli uricemici erano significativamente più elevati che nelle seconde (p<0,001). In entrambi i sessi, essi aumentavano in maniera significativa con l’età. In 17 diabetici su 25 (68%) aventi livelli uricemici superiori a quelli «normali», i valori dell’azotemia superavano i 40 mg/100 ml. I risultati del presente studio non suffragano l’ipotesi secondo cui tra gotta, iperuricemia e diabete mellito esisterebbe una relazione significativa.

Résumé

La ressemblance chimique entre l’urate et l’alloxane suggéra de mésurer le niveau de l’urate dans le sérum de 314 sujets diabétiques. Un patient seulement était goutteux et personne ne possedait un précédent de goutte dans sa famille. Le niveau moyen de l’urate dans le sérum était de 4,8 mg/100 ml (SD ± 1,57) pour les hommes, et de 4,2 mg/100 ml (SD ± 1,59) pour les femmes. Les valeurs étaient significativement plus élévées pour les hommes que pour les femmes (p ≤ 0,001) et, dans les deux cas, elles augmentaient de façon significative avec l’âge des patients. Soixante-huit pour cents des diabétiques avec un niveau d’urate hors de la règle, c’est à dire 17 patients sur 25, possédait un niveau d’azotémie supérieur à 40 mg/100 ml. Cet étude ne confirme pas l’hypothèse d’une relation significative entre goutte, hyperuricémie et diabète.

Resumen

La semejanza química existente entre ácido úrico y aloxana ha inducido al autor a realizar determinaciones de la uricemia en 314 individuos diabéticos. Sólo un paciente estaba afectado de gota, mientras que la enfermedad no figuraba en la anamnesis familiar de ninguno de ellos. El valor medio de la uricemia era de 4,8 mg/100 ml (SD ± 1,57) en los hombres y de 4,2 mg/100 ml (SD ± 1,59) en las mujeres. En los primeros, los niveles uricémicos eran significativamente más elevados que en las segundas (p<0,001). En ambos sexos, aquéllos aumentaban con la edad de modo significativo. De 25 diabéticos, en 17 (68%) con niveles uricémicos superiores a los «normales», los valores de la azoemia superaban los 40 mg/100 ml. Los resultados del presente estudio no abonan la hipótesis de que entre gota, hiperuricemia y diabetes mellitus exista una relación significativa.

Zusammenfassung

Die Ähnlichkeit der chemischen Beschaffenheit von Harnsäure und Alloxan veranlasste den Verfasser bei 314 Diabetikern den Harnsäurespiegel des Blutes zu bestimmen. Nur ein Patient litt an Gicht, während bei keinem eine positive Familienanamnese für Gicht bestand. Der mittlere Harnsäurespiegel im Blut betrug 4,8 mg/100 ml (SD ± 1,57) bei den männlichen und 4,2 mg/100 ml (SD ± 1,59) bei den weiblichen Patienten. Die Werte waren bei den Männern wesentlich höher als bei den Frauen (p<0,001). Bei beiden Geschlechtern nahm die Harnsäurekonzentration im Blut mit dem Alter stark zu. Bei 17 von 25 (68%) Diabetikern mit über die «Norm» erhöhtem Harnsäurespiegel war auch der Blutstickstoff höher als 40 mg/100 ml. Aufgrund der Ergebnisse der vorliegenden Untersuchung erscheint die Hypothese, dass zwischen Gicht, Hyperurikämie und Diabetes mellitus eine bedeutsame Beziehung besteht, nicht gerechtfertigt.

Summary

The chemical similarity between urate and alloxan stimulated the measurement of serum urate in 314 diabetics. Only one patient had gout and none had a family history of gout. The mean serum urate level in males was 4.8 mg/100 ml (SD ± 1.57) whilst the mean value in females was 4.2 mg/100 ml (SD ± 1.59). Males had significantly higher levels than females (p<0.001). The levels in both sexes increased significantly with age. Seventeen of the 25 diabetics (68%) with serum urate levels above the ‘normal’ range were known to have blood urea levels of over 40 mg/100 ml. This study does not support the hypothesis of a significant relationship between gout, raised serum urate levels and diabetes mellitus.

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References

  1. Archibald R. M.: Colorimetric Measurement of Uric Acid — Clin. Chem.3, 102, 1957.

    PubMed  CAS  Google Scholar 

  2. Beckett A. G., Lewis J. G.: Gout and the Serum Uric Acid in Diabetes Mellitus — Quart. J. Med.29, 443, 1960.

    PubMed  CAS  Google Scholar 

  3. Berkowitz D.: Blood Lipid and Uric Acid Interrelationships — J. Amer. med. Ass.190, 856, 1964.

    CAS  Google Scholar 

  4. Berkowitz D.: Gout, Hyperlipidemia, and Diabetes Interrelationships — J. Amer. med. Ass.197, 77, 1966.

    Article  CAS  Google Scholar 

  5. Brøchner-Mortensen K., Cobb S., Rose B. S.: Report of Sub-Committee on Criteria for the Diagnosis of Gout in Surveys — In:Kellgren J. H. (Ed.): The Epidemiology of Chronic Rheumatism. F. A. Davis Co., Philadelphia, 1963; vol. 1, p. 295.

    Google Scholar 

  6. Cannon P. J., Stason W. B., Demartini F. E., Sommers S. C., Laragh J. H.: Hyperuricaemia in Primary and Renal Hypertension — New Engl. J. Med.275, 457, 1966.

    Article  PubMed  CAS  Google Scholar 

  7. De Wardener H. E.: The Kidney — J. & A. Churchill, London, 1967; p. 357.

    Google Scholar 

  8. Duncan H., Dixon A. St. J.: Gout, Familial Hyperuricaemia and Renal Disease — Quart. J. Med.29, 127, 1960.

    PubMed  CAS  Google Scholar 

  9. Dunn J. P., Moses C.: Correlation of Serum Lipids with Uric Acid and Blood Sugar in Normal Males — Metabolism14, 788, 1965.

    Article  CAS  Google Scholar 

  10. Dunn J. S., Sheehan H. L., McLetchie N. G. B.: Necrosis of Islets of Langerhans Produced Experimentally — Lancet1, 484, 1943.

    Google Scholar 

  11. Gout and Diabetes Mellitus — Brit. med. J.2, 1280, 1966.

  12. Griffiths M.: Uric Acid Diabetes — J. biol. Chem.172, 853, 1948.

    CAS  PubMed  Google Scholar 

  13. Griffiths M.: The Mechanism of the Diabetogenic Action of Uric Acid — J. biol. Chem.184, 289, 1950.

    PubMed  CAS  Google Scholar 

  14. Hall A. P., Barry P. E., Dawber T. R., McNamara P. M.: Epidemiology of Gout and Hyperuricaemia — Amer. J. Med.42, 27, 1967.

    Article  PubMed  CAS  Google Scholar 

  15. Holland W. W., Trevelyan H.: Personal communication, 1972.

  16. Ishmael W. K.: The Familial Aspects of Gout, Diabetes Mellitus and Obesity — J. Okla. St. med. Ass.38, 415, 1945.

    Google Scholar 

  17. Joslin E. P., Root H. F., White P., Marble A. (Eds): The Treatment of Diabetes Mellitus — Lea & Febiger, Philadelphia, 1959; p. 92.

    Google Scholar 

  18. Kellgren J. H.: Diagnosis in Arthritis — In:Trounce J. R. (Ed.): Second Symposium on Advanced Medicine. Roy. Coll. of Physicians, London, 1965; p. 173.

    Google Scholar 

  19. Lazarow A.: Development and Progression of Diabetes — Physiol. Rev.29, 48, 1949.

    CAS  PubMed  Google Scholar 

  20. Liddle L., Seegmiller J. E., Laster L.: The Enzymatic Spectrophotometric Method for the Determination of Uric Acid — J. Lab. clin. Med.54, 903, 1959.

    PubMed  CAS  Google Scholar 

  21. Malins J.: Clinical Diabetes Mellitus — Eyre and Spottiswoode, London, 1968; p. 267.

    Google Scholar 

  22. Mikkelsen W. M., Dodge H. J., Valkenburgh H.: The Distribution of Serum Uric Acid Values in a Population Unselected as to Gout or Hyperuricaemia — Amer. J. Med.39, 242, 1965.

    Article  PubMed  CAS  Google Scholar 

  23. Popert A. J., Hewitt J. V.: Gout and Hyperuricaemia in Rural and Urban Populations — Ann. Rheum. Dis.21, 154, 1962.

    Article  PubMed  CAS  Google Scholar 

  24. Prior I. A. M., Rose B. S., Davidson F.: Metabolic Maladies in New Zealand Maoris — Brit. med. J.1, 1065, 1964.

    Article  PubMed  CAS  Google Scholar 

  25. Thompson R. H. S., King E. J.: Biochemical Disorders in Human Disease — 2nd ed. J. & A. Churchill, London, 1964; p. 660.

    Google Scholar 

  26. van Noorden C. H., Isaac S.: Die Zuckerkrankheit (Diabetes mellitus) — Springer-Verlag, Berlin, 1927.

    Google Scholar 

  27. Whitehouse F. W., Cleary W. J. Jr.: Diabetes Mellitus in Patients with Gout — J. Amer. med. Ass.197, 73, 1966.

    Article  CAS  Google Scholar 

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  1. Department of Medicine, University of Dundee, DD1 4HN, Dundee, Great Britain

    Louis Herzberg

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Traduzione a cura di G. U.

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Herzberg, L. Diabetes mellitus, serum urate and gout. A study in 314 patients. Acta diabet. lat 10, 1202–1215 (1973). https://doi.org/10.1007/BF02590711

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