Summary
Glucose tolerance, plasma FFA and insulin response following an oral glucose load (1 g/kg body weight) were studied in normal healthy subjects of different age groups. Although there was no obvious loss of glucose tolerance, the peak and 120 min blood glucose levels, and the glucose area under the glucose curve in the sixth decade were significantly higher than in the other decades. Fasting plasma FFA levels were also significantly elevated in the sixth decade but the insulin response was normal. The subtle degree of loss of glucose tolerance observed in the sixth decade could be either due to decreased sensitivity to insulin produced by elevated plasma FFA or atherosclerotic changes interfering with ready availability of circulating insulin to the tissues.
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Sinha, M.K., Mondal, A.N. & Rastogi, G.K. Influence of age on glucose tolerance in normal subjects. Acta diabet. lat 11, 78–83 (1974). https://doi.org/10.1007/BF02581942
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DOI: https://doi.org/10.1007/BF02581942