Abstract
Photodynamic therapy of cancer (PDT) at early stages of various types of cancer is based on the use of the phototoxicity of photosensitizers (PS) which appears upon their excitation by light in tumor tissues. The review concentrates mainly on the data for the second and third generations of photosensitizers: the structure of PS, their photophysical and photochemical properties, and some results of theirin vitro andin vivo application. A carefully designed PS should exhibit the following properties: long-wave absorption, good singlet oxygen quantum yield, an intramolecular polarity axis, and lowin vivo (photooxidation) stability. Uncharged PS that are lipophilic, positively charged, and capable of binding with monoclonal antibodies are discussed as an example.
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Universität Bremen, Fachbereich 2 (Biologie/Chemie), Institut für Organische und Makromolekulare Chemie, Postfach 330 440, D-28334 Bremen, Deutschland.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 836–845, May, 1998.
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Wöhrle, D., Hirth, A., Bogdahn-Rai, T. et al. Photodynamic therapy of cancer: Second and third generations of photosensitizers. Russ Chem Bull 47, 807–816 (1998). https://doi.org/10.1007/BF02498146
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DOI: https://doi.org/10.1007/BF02498146