Abstract
The coupling of urethane protected amino acidfluorides is accomplished in the presence ofactivated, commercial zinc dust to synthesize severaldi- and tripeptides.The coupling was fast and racemization free. The yieldas well as purity of the peptides was satisfactory.The method was extended for the incorporation ofsterically hindered α,α-dialkylaminoacids and N-methylamino acids as well.
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Suresh Babu, V.V., Ananda, K. Synthesis of peptides employing Fmoc-/Boc-/Z-amino acid fluorides and activated commercial zinc dust. Letters in Peptide Science 7, 41–46 (2000). https://doi.org/10.1023/A:1008982020303
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DOI: https://doi.org/10.1023/A:1008982020303