Abstract
Increasing attention is being paid to the relationship between nutrition and health, particularly in regard to the possible linkage between nutrition and the development of chronic disease. The elderly are likely to suffer from one or more chronic diseases. The impact of these diseases on mineral status of the elderly population is poorly understood. In addition, little information is available about the mineral requirements of this population. The focus of this paper is to review the reasons why the elderly population is at increased risk of developing mineral deficiencies, our current understanding of the mineral requirements of this vulnerable group, and a consideration of recommendations for future research needs in this area. For illustrative purposes, special attention has been given to three selected mineral nutrients: phosphorus, magnesium and zinc. Research priorities include studies to: improve methods for assessing mineral status; investigate the relation of habitual mineral intake and status; assess the impact of dietary change on mineral bioavailability in the elderly; determine the effect of hypochlorhydria on intestinal mineral absorption; and assess the effects of aging on the adaptive response to low mineral intakes. Studies such as these will help to provide a stronger research data base for estimating Recommended Dietary Allowances for these mineral nutrients in the elderly.
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References
Report of the task force on the evidence relating six dietary factors to the nation’s health. Am. J. Clin. Nutr., 32: 2621–2748, 1979.
U.S. Dept. of Health and Human Services, Public Health Service National Center for Health Statistics. Health Statistics for Older Persons. U.S., 1986. Analytical and Epidemiological Studies. Series 3, No. 25. Hyattsville, MD. Natl. Ctr. for Health Stat., June 1987.
Spencer, G.: Projections of the Population of the United States, by age, sex, and race: 1983 to 2080. U.S. Bureau of the Census, Current Population Reports, Series p-25, No. 952. Washington, D.C.: U.S. Printing Office, May, 1984.
National Council on Aging. Fact Book on Aging: A Profile of America’s Older Population. 1978, Washington, D.C.: Natl. Counc. on the Aging, inc.
U.S. Dept. of Health, Education, and Welfare. Public Health Service, National Institutes of Health. Patterns of Disease Among the Aged. N.I.H. Publication No. 79-1407, Revised July 1979.
Lofholm, P.: Self-medication in the elderly, in Drugs and the Elderly, edited by Kayne, R.C., Los Angeles, Univ. of Southern Calif. Press, 1978, p. 8.
Recommended Dietary Allowances. Subcommittee on the Tenth Edition of the RDAs. Food and Nutrition Board. Commission on Life Sciences. Natl. Res. Counc. Natl. Acad. Press, Washington, D.C., 1989.
Dean, W.: Biological Aging Measurements: Clinical Applications. Los Angeles, The Ctr. for Bio-Gerontol., 1988.
Shock, N.W.: Physiological aspects of aging. J. Am. Dietet. Assoc., 56: 491–496, 1970.
Rowe, J.W. and Kahn, R.L.: Human aging: usual and successful. Science, 237: 143–149, 1987.
Munro, H.N.: Aging and nutrition: a multifaceted problem, in Nutrition and Aging, edited by Hutchinson, M.L. and Munro, H.N., San Diego, Acad. Press., 1986, pp. 1–10.
Nutrition and Your Health: Dietary Guidelines for Americans. Third Edition, 1990. U.S. Dept. of Agric. and U.S. Dept. of Health and Human Svcs. Home and Garden Bulletin No. 232.
American Heart Association. Dietary guidelines for healthy American adults: a statement for physicians and health professionals by the Nutrition Committee, American Heart Association. Circul., 74: 1465A–1468A, 1986.
Spivey Fox, M.R. and Tao, S.H.: Antinutritive effects of phytate and other phosphorylated derivatives, in Nutritional Toxicology, Vol. III, edited by Hathcock, J.N., San Diego, Acad. Press, INc., 1989, pp. 59–96.
Schiller, L.R., Santa Ana, C.A., Sheikh, M.S., Emmett, M., and Fortran, J.S.: Effect of the time of administration of calcium acetate on phosphorus binding. New Engl. J. Med., 320: 1110–1113, 1989.
Freeland-Graves, J.: Mineral adequacy of vegetarian diets. Am. J. Clin. Nutr., 48: 859–862, 1988.
Roe, D.A.: Drug-Induced Nutritional Deficiencies, Second Edition. Westport, Avi Pub. Co., Inc., 1985.
Martin, B.J. and Milligan, K.: Diuretic-associated hypomagnesemia in the elderly. Arch. Intern. Med., 147: 1768–1771, 1987.
Ramirez, J.A., Emmett, M., White, M.G., Fathi, N., Santa Ana, C.A., Morawski, S.G., and Fordtran, J.S.: The absorption of dietary phosphorus and calcium in hemodialysis patients. Kidney Internat., 30: 753–759, 1986.
Chen, L.H., Liu, S., Cook Newell, M.E., and Barnes, K.: Survey of drug use by the elderly and possible impact of drugs on nutritional status. Drug-Nutrient Interact., 3: 73–86, 1985.
Armbrecht, H.J., Zenser, T.V., Gross, C.J., and Davis, B.B.: Adaptation to dietary calcium and phosphorus restriction changes with age. Am. J. Physiol., 239: E322–E327, 1980.
Ireland, P. and Fortran, J.S.: Effect of dietary calcium and age on jejunal calcium absorption in humans studied by intestinal perfusion. J. Clin. Invest., 52: 2672–2681, 1973.
Kassarjian, Z. and Russell, R.M.: Hypochlorhydria: a factor in nutrition. Ann. Rev. Nutr., 9: 271–285, 1989.
Krasinski, S.D., Russell, R.M., and Samloff, I.M.: Fundic atrophic gastritis in an elderly population. J. Am. Geriatr. Soc., 34: 800–806, 1986.
Faber, K.: Achylia gastrica mit anamie. Med. Klin., 5: 1310, 1909.
Ivanovich, P., Fellows, H., and Rich, C.: The absorption of calcium carbonate. Ann. Intern. Med., 66: 917–923, 1967.
Recker, R.R.: Calcium absorption and achlorhydria. N. Engl. J. Med., 313: 70–73, 1985.
Bo-Linn, G.W., Davis, G.R., Buddrus, D.J., Morawski, S.G., Santa Ana, C., and Fordtran, J.S.: An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium. J. Clin. Invest., 73: 640–647, 1984.
Knox, T.A., Kassarjian, Z., Dawson-Hughes, B., Golner, B.B., Dallal, G.E., Arora, S., and Russell, R.M.: Calcium absorption in elderly subjects on high-and low-fiber diets: effect of gastric acidity. Am. J. Clin. Nutr., 53: 1480–1486, 1991.
Armbrecht, H.J.: Age-related changes in calcium, phosphorus and osmolality homeostasis — role of the kidney, in Homeostatic Function and Aging, edited by Davis, B.B. and Wood, W.G., New York, Raven Press, 1985, pp. 1–14.
Tsai, K-S., Heath, H., Kumar, R., and Riggs, L.: Impaired vitamin D metabolism with aging in women. J. Clin. Invest., 73: 1668–1672, 1984.
Wood, R.J., Theall, C., Contois, J.H., and Rosenberg, I.H.: Intestinal end-organ resistance to 1,25-dihydroxyvitamin D stimulation of calcium absorption in the senescent rat, in Vitamin D: Molecular, Cellular and Clinical Endocrinology, edited by Norman, A.W., Schaefer, K., Grigolet, H.G., and Herrath, D.V., Berlin, Walter de Gruyter, 1988, pp. 907–908.
Turnlund, J.R., Durkin, N., Costa, F., and Margen, S.: Stable isotope studies of zinc absorption and retention in young and elderly men. J. Nutr., 116: 1239–1247, 1986.
Disorders of Mineral Metabolism, Vol. III, Pathophysiology of Calcium, Phosphorus and Magnesium, edited by Bronner, F. and Coburn, J.W., New York, Academic Press, 1981.
Escoubet, B., Djabali, K., and Amiel, C.: Adaptation to Pi deprivation of cell Na-dependent Pi uptake: a widespread process. Am. J. Physiol., 256: C322–C328, 1989.
Shils, M.: Experimental human magnesium depletion. Medicine (Baltimore), 48: 61–85, 1969.
Munro, H.N.: Nutrient needs and nutritional status in relation to aging. Drug-Nutr. Interact., 4: 55–74, 1985.
Lichtman, M.A., Murphy, M.S., Byer, B.J., and Freeman, R.B.: Haemoglobin affinity for oxygen in chronic renal disease: the effects of haemodialysis. Blood, 43: 417–424, 1974.
Aloia, J.F., Vaswani, A., Yeh, J.K., Ellis, K., and Cohn, S.H.: Total body phosphorus in postmenopausal women. Min. Electro. Metab., 10: 73–76, 1984.
MacIntyre, I., Hanna, S., Booth, C.C., and Read, A.E.: Intracellular magnesium deficiency in man. Clin. Sci., 20: 297–305, 1960.
Bengoa, J. and Wood, R.: Magnesium, in Absorption and Malabsorption of Mineral Nutrients, edited by Solomons, N.W. and Rosenberg, I.H., New York, Alan R. Liss, Inc., 1984, pp. 69–88.
Sjogren, A., Floren, C-H., and Nilsson, A.: Magnesium and potassium status in healthy subjects as assessed by analysis of magnesium and potassium in skeletal muscle biopsies and magnesium in mononuclear cells. Magnesium, 6: 91–99, 1987.
Solomons, N. and Cousins, R.J.: Zinc, in Absorption and Malabsorption of Mineral Nutrients, edited by Solomons, N.W. and Rosenberg, I.H, New York, Alan R. Liss, Inc., 1984, pp. 125–198.
Grider, A., Bailey, L.B., and Cousins, R.J.: Erythrocyte metallothionein as an index of zinc status in humans. Proc. Natl. Acad. Sci. USA, 87: 1259–1262, 1990.
Cook, J.D. and Skikne, B.S.: Serum ferritin: a possible model for the assessment of nutrient stores. Am. J. Clin. Nutr., 35: 1180–1185, 1982.
Berner, Y.N. and Shike, M.: Consequences of phosphate imbalance. Ann. Rev. Nutr. 8: 121–148, 1988.
Touitou, Y., Godard, J-P., Ferment, O., Chastang, C., Proust, J., Bogdan, A., Auzeby, A., and Touitou, C.: Prevalence of magnesium and potassium deficiencies in the elderly. Clin. Chem., 33: 518–523, 1987.
Lowenstein, F.W. and Stanton, M.F.: Serum magnesium levels in the United States, 1971–1974. J. Am. Coll. Nutr., 5: 399–414, 1986.
Pilch, S.M. and Senti, F.R.: Assessment of zinc nutritional status of the US population based on data collected in HANES II survey, 1976–80. Rockville, MD: Fed. of Amer. Soc. for Exp. Biol. (Life Sci. Res. Off), 1984.
Lindeman, R.D., Clark, M.L., and Colmore, J.F.: Influence of age and sex on plasma and red-cell zinc concentrations. J. Gerontol., 26: 358–363, 1971.
Yendt, E.R., Cohanim, M., and Rosenberg, G.M.: Reduced serum calcium and inorganic phosphate levels in normal elderly women. J. Gerontol. 41: 325–330, 1986.
Thomas, A.J., Bunker, V.W., Sodha, N., and Clayton, B.E.: Calcium, magnesium and phosphorus status of elderly inpatients: dietary intake, metabolic balance studies and biochemical status. Br. J. Nutr., 62: 211–219, 1989.
Dawson-Hughes, B., Dallal, G.E., Krall, E.A., Sadowski, L., Sahyoun, N., and Tannenbaum, S.A.: A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N. Engl. J. Med., 323: 878–883, 1990.
Karanja, N. and McCarron, D.A.: Calcium and hypertension. Ann. Rev. Nutr., 6: 475–494, 1986.
Lipkin, M. and Newmark, H.: Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at risk for familial colon cancer. N. Engl. J. Med., 313: 1381–1384, 1985.
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Symposium Paper: Aging and Nutrition. Presented on October 5, 1990 during the 20th Annual Meeting of AGE in New York City.
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Wood, R.J. Mineral needs of the elderly: Developing a research agenda for the 1990s. AGE 14, 120–128 (1991). https://doi.org/10.1007/BF02435018
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DOI: https://doi.org/10.1007/BF02435018