Summary
We studied the renal urate excretory function in two groups of hyperuricaemic male patients composed of individuals with associated hyperlipidemia and hyperuricaemic-normolipidemic individuals, respectively. Both the hyperlipidemia and the hyperuricaemia were primary inasmuch as none of the patients studied was obese or had an above-normal alcohol intake or blood hypertension. The results obtained show that hyperuricaemic-hyperlipidemic patients have higher serum levels of uric acid and poorer urate excretion as reflected in smaller clearance and fractioned excretion of the metabolite than hyperuricaemic-normolipidemic patients. This, in turn, suggests the occurrence of differences in the extent of the urate handling anomalies between the two groups of patients.
Similar content being viewed by others
References
Levinson, D.J. Clinical gout and the pathogenesis of hyperuricaemia. In: Arthritis and Allied Conditions. Ed.: McCarty, D.J., Philadelphia, Lea and Fabiger, 1989, pp. 1645–1676.
Grantham, J.J., Chonko, A.M. Renal handling of organic anions and cations. Metabolism and excretion of uric acid. In: The Kidney. Eds: Brenner, B.M., Rector, F.C. Jr. Philadelphia, W.B. Saunders, 1986, pp. 663–700.
Levinson, D.J., Sorensen, L.B. Renal handling of uric acid in normal and gouty subjects. Evidence for a 4-component system. Ann Rheum Dis 1980, 39, 173–179.
Puig, J.G., Mateos, F.A., Jiménez, M.L., Ramos, T.H. Renal excretion of hypoxanthine and xanthine in primary gout. Am J Med 1988, 85, 533–537.
Steele, T.H. Urate excretion in man, normal and gouty. In: Uric Acid. Ed: Kelley, W.N., New York, Springer-Verlag, 1978, pp. 257–280.
Palella, T.D., Fox, I.H. Hyperuricemia and gout. In: The Metabolic Basis of Inherited Diseases. Eds: Seriver, C.R., Beandet, A.L., Sly, W.S., Valle, D. New York, McGraw-Hill, 1989, pp. 965–1006.
Yu, T.F., Dorph, D.J., Smith, H. Hyperlipidemia in primary gout. Semin Arthritis Rheum 1978, 7, 233–244.
Kiao, S., Kameda, K., Matsuzaway, Y., Tarui, S. Hiperlipoproteinaemia phenotype and influence of alcohol intake and obesity in Japan. Ann Rheum Dis 1978, 45, 308–313.
Collantes, E., Pineda, M., Anón, J., Sánchez, P., Hyperuricaemia-hyperlipemia association in the absence of obesity and alcohol abuse. Clin Rheumtol 1990, 9, 28–31.
Ferns, G.A.A., Lanham, J., Galton, D.J. The association between primary gout and hypertrygliceridemia may be due to genetic linkage. Basel, Karger, Monograph Atherosc 1985, 13, 121–123.
Collantes, E., Añón, J., Tinahones, F.J., Sánchez, P. Perfil lipídico asociado a hiperuricemia asintomática. Rev Esp Reum 1989, 16, 129–131.
Mann, G.U. The influence of obesity on health. N Engl J Med 1978, 226, 1974.
Strategy for the prevention of the coronary heart disease: a policy statement of the European Artherosclerosis Society. Eur Heart J 1987, 77–88.
Ulreich, A., Kostner, G.M., Pfipffer, K.P., Seldmayer, P., Reiner, F. Serum lipids and lipoproteins in patients with primary gout. Rheumatol Intern 1985, 5, 73–76.
L.G. Darlington, J.T. Scott. Can risk scores for vascular disease in gout patients be improved? Adv Exp Med Biol 1980, 122A, 197–204.
Kelley, W.N., Fox, I.H., Palella, T.D., Gout and related disorders of purine metabolism. In: Textbook of Rheumatology. Eds.: Kelley, W.N., Harris, E.D. Jr., Ruddy, S., Sledger, C.B.. Philadelphia, W.B. Saunders, 1989, pp. 1495–1448.
J.R. Klinemberg, I. Kipen. The binding of urate to plasma proteins determined by means of equilibrium dialysis. J Lab Clin Med 1970, 75, 503–509.
Taddeo, A., Morozzi, G., Marcolongo, R. Is gout related to an alteration of the uric acid protein binding? Adv Exp Med Biol 1980, 122A, 225–230.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Estevéz, E.C., Madueño, F.J.T., Ruiz, A.G. et al. Renal excretion of urate by hyperuricaemic-hyperlipidemic patients. Clin Rheumatol 11, 498–501 (1992). https://doi.org/10.1007/BF02283105
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02283105