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Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25

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Somatic Cell and Molecular Genetics

Abstract

Acyl coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A. It is believed that ACAT plays a key role in lipoprotein metabolism and atherogenesis. Recently our laboratory succeeded in molecular cloning and functional expression of human macrophage ACAT cDNA. We have now mapped the ACAT gene to chromosome 1, band q25 by using fluorescence in situ hybridization to metaphase chromosomes, and by Southern blotting analysis of human-hamster somatic cell hybrid panels.

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Literature Cited

  1. Sliskovic, D.R., and White, A.D. (1991).Trends Pharmacol. Sci. 12:194–199.

    Google Scholar 

  2. Brown, M.S., and Goldstein, J.L. (1983).Annu. Rev. Biochem. 52:223–261.

    Google Scholar 

  3. Ross, R. (1986).N. Engl. J. Med. 314:488–500.

    Google Scholar 

  4. Chang, T.Y., and Doolittle, G.M. (1983).Enzymes 16:523–539.

    Google Scholar 

  5. Chang, C.C., Huh, H.Y., Cadigan, K.M., and Chang, T.Y. (1993).J. Biol. Chem. 268:20747–20755.

    Google Scholar 

  6. Ijdo, J.W., Lindsay, E.A., Wells, R.A., and Baldini, A. (1992).Genomics 14:1019–1025.

    Google Scholar 

  7. Baldini, A., Ross, M.T., Nizetic, D., Vatcheva, R., Lindsay, E.A., Lehrach, H., Siniscalco, M. (1992).Genomics 14:181–184.

    Google Scholar 

  8. Lusis, A.J. (1993).Trends Cardiovasc. Med. 3:135–143.

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire

    Catherine C. Y. Chang, Walter Chang & Ta Yuan Chang

  2. Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire

    Walter W. Noll & Nancy Nutile-McMenemy

  3. Baylor College of Medicine, Institute for Molecular Genetics and Human Genome Center, Houston, Texas

    Elizabeth A. Lindsay & Antonio Baldini

Authors
  1. Catherine C. Y. Chang
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  2. Walter W. Noll
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  3. Nancy Nutile-McMenemy
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  4. Elizabeth A. Lindsay
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  5. Antonio Baldini
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  6. Walter Chang
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  7. Ta Yuan Chang
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Chang, C.C.Y., Noll, W.W., Nutile-McMenemy, N. et al. Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25. Somat Cell Mol Genet 20, 71–74 (1994). https://doi.org/10.1007/BF02257489

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  • DOI: https://doi.org/10.1007/BF02257489

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