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Neuroendocrine effects of sumatriptan

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Abstract

The neuroendocrine effects of the 5-HT receptor agonist, sumatriptan (6 mg subcutaneously), were studied in 11 healthy male subjects using a placebo-controlled, cross-over design. Compared to placebo, sumatriptan significantly lowered levels of plasma prolactin but increased those of plasma growth hormone. There was no effect on plasma cortisol concentrations. The neuroendocrine effects of sumatriptan differ from those of previously described 5-HT-receptor agonists, and may be a consequence of selective activation of 5-HT1D or 5-HT1B receptors. However, the present data cannot exclude the possibility that the neuroendocrine changes reflect non-specific stress responses or changes in pituitary blood flow.

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References

  • Anderson IM, Cowen PJ, Grahame-Smith DG (1990) The effect of gepirone on neuroendocrine function in humans. Psychopharmacology 100:498–503

    Google Scholar 

  • Checkley SA (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychol Med 10:35–53

    PubMed  Google Scholar 

  • Connor HE, Feniuk W (1992) Migraine, serotonin and sumatriptan. Vasc Med Rev 3:95–108

    Google Scholar 

  • Cowen PJ (1992) Neuroendocrine measures of 5-HT receptor subtype function in depression. In: Bradley PB, Handley SL, Cooper SJ, Key BJ, Barnes NM, Coote JH (eds) Serotonin, CNS receptors and brain function. Pergamon Press, Oxford, pp 287–296

    Google Scholar 

  • Cowen PJ, Anderson IM, Grahame-Smith DG (1990) Neuroendocrine effects of azapirones. J Clin Psychopharmacol 10:21S-25S

    PubMed  Google Scholar 

  • Cryer PE, Daughaday WH (1977) Growth hormone. In: Martini L, Besser GM (eds) Clinical neuroendocrinology. Academic Press, New York, pp 243–277

    Google Scholar 

  • Dallas FA, Dixon CM, McCulloch RJ, Saynor DA (1989) The kinetics of14C-GR43175 in rat and dog. Cephalalgia 9 [Suppl 9]:53–56

    Article  Google Scholar 

  • Dechant KL, Clissold SP (1992) Sumatriptan: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs 43:776–798

    PubMed  Google Scholar 

  • Eckland DJ, Entwisle SJ, Fowler PA, Thomas M, Lettis S, York M, Freedman PS (1992) The effects of sumatriptan, a 5-HT1-like agonist on pituitary adrenal function in healthy volunteers. Br J Clin Pharmacol 33:538P

  • Gartside SE, Ellis PM, Sharp T, Cowen PJ (1992) Selective 5-HT1A and 5-HT2 receptor-mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments. Eur J Pharmacol 221:27–33

    Article  PubMed  Google Scholar 

  • Gilbert F, Brazell C, Tricklebank MD, Stahl SM (1988) Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration. Eur J Pharmacol 147:431–439

    Article  PubMed  Google Scholar 

  • King BH, Brazell C, Dourish CT, Middlemiss DN (1989) MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype. Neurosci Lett 105:174–176

    Article  PubMed  Google Scholar 

  • Lesch KP (1992) 5-HT1A receptor responsivity in anxiety disorders and depression. Prog Neuro Psychopharmacol Biol Psychiatry 15:723–733

    Article  Google Scholar 

  • Lowther S, De Paermentier FD, Crompton MR, Horton RW (1992) The distribution of 5-HT1D and 5-HT1E binding sites in human brain. Eur J Pharmacol 222:137–142

    Article  PubMed  Google Scholar 

  • Meltzer HY, Nash JF (1988) Serotonin and mood: neuroendocrine aspects. In: Ganten D, Pfaff D (eds) Current topics in neuroendocrinology, Vol 8. Springer, Berlin Heidelberg New York, pp 183–210

    Google Scholar 

  • Middlemiss DN, Bremer ME, Smith SM (1988) A pharmacological analysis of the 5-HT receptor mediating inhibition of 5-HT release in the guinea pig frontal cortex. Eur J Pharmacol 157:101–104

    Article  PubMed  Google Scholar 

  • Montage, M, Calas A (1988) Serotonin and endocrinology — the pituitary. In: Osborne NN, Hamon M (eds) Neuronal serotonin Wiley, Chichester, pp 271–303

    Google Scholar 

  • Oksenberg D, Marsters SA, O'Dowd BF, Jin H, Havlik S, Peroutka SJ, Ashkenazi A (1992) A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors. Nature 360:161–163

    Article  PubMed  Google Scholar 

  • Peroutka SJ (1992) Molecular biology of 5-HT receptor subtypes. In: Bradley PB, Handley SL, Cooper SJ, Key BJ, Barnes NM, Coote JH (eds) Serotonin, CNS receptors and brain function. Pergamon, Oxford, pp 1–11

    Google Scholar 

  • Peroutka SJ, McCarthy BG (1989) Sumatriptan (GR43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol 163:133–136

    Article  PubMed  Google Scholar 

  • Rolandi E, Franceschini R, Cataldi A, Barreca T (1992) Endocrine effects of sumatriptan. Lancet 339:1365

    Article  Google Scholar 

  • Schlicker E, Fink K, Gothert M, Hoyer D, Molderings G, Roschke I, Schoeffter P (1989) The pharmacological properties of presynaptic serotonin autoreceptors in pig brain cortex conform to the 5-HT1D receptor subtype. Naunyn-Schmiedeberg's Arch Pharmacol 340:45–51

    Google Scholar 

  • Schoeffter P, Hoyer D (1989) How selective is GR43175? Interactions with functional 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Nauyn-Schmiedeberg's Arch Pharmacol 340:135–138

    Google Scholar 

  • Sleight AJ, Cevenka A, Peroutka SJ (1990) In vivo effects of sumatriptan (GR43175) on extracellular levels of 5-HT in the guinea pig. Neuropharmacology 29:511–513

    Article  PubMed  Google Scholar 

  • Tuomisto J, Mannisto P (1985) Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 37:249–332

    PubMed  Google Scholar 

  • Wilkinson LO, Middlemiss DN (1992) The autoregulation of 5-HT release from nerve terminals in vitro. In: Bradley PB, Handley SL, Cooper SJ, Key BJ, Barnes NM, Coote JH (eds) Serotonin, CNS receptors and brain function. Pergamon, Oxford, pp 1–11

    Google Scholar 

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Herdman, J.R.E., Delva, N.J., Hockney, R.E. et al. Neuroendocrine effects of sumatriptan. Psychopharmacology 113, 561–564 (1994). https://doi.org/10.1007/BF02245240

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  • DOI: https://doi.org/10.1007/BF02245240

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