Skip to main content
SpringerLink
Log in

Secretion of pancreatic enzymes

III. Response of patients with cirrhosis to secretin and pancreozymin

  • Symposium On Gastrointestinal Motility Leuven, Belgium April 22, 1966
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

Pancreatic function in patients with portal cirrhosis was evaluated by measurement of the amount of amylase, lipase, phospholipase A, carboxypeptidase, trypsin, and chymotrypsin secreted into the duodenum during the 30-min. period after the onset of a simultaneous infusion of secretin and pancreozymin. The volume and bicarbonate concentration of the fluid were also measured. Enzyme secretion varied greatly. Approximately 40% of patients had abnormally low enzyme values and bicarbonate concentration. Those with severe cirrhosis had significantly poorer pancreatic function as reflected in secretion of enzymes. Intercorrelations among the several enzymes measured were significantly positive but not high, similar in all respects to those previously observed in patients without cirrhosis. In two-thirds of the patients with cirrhotic livers, the volume of duodenal aspirate obtained after infusion of secretin and pancreozymin exceeded the highest volume previously recorded in a sample of normal men. A low volume was observed in only 2 of 34 patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Friedman, A. I., andCheng, L. K. Pancreatic function in portal cirrhosis.Amer J Gastroent 35:492, 1961.

    PubMed  Google Scholar 

  2. Baraona, E., Orrego, H., Fernandez, O., Amenalear, E., Maldonado, E., Tag, F., andSalinas, A. Absorptive function of the small intestine in liver cirrhosis.Amer J Dig Dis 7:318, 1962.

    Article  PubMed  Google Scholar 

  3. Van Goidsenhoven, G. E., Henke, W. J., Vacca, J. B., andKnight, W. A., Jr. Pancreatic function in cirrhosis of the liver.Amer J Dig Dis 8:160, 1963.

    Google Scholar 

  4. Zieve, L., Silvis, S. E., Mulford, B., andBlackwood, W. D. Secretion of pancreatic enzymes. I. Response to secretin and pancreozymin.Amer J Dig Dis 11:671, 1966.

    PubMed  Google Scholar 

  5. Sobel, H. J., andWaye, J. D. Pancreatic changes in various types of cirrhosis in alcoholics.Gastroenterology 45:341, 1963.

    PubMed  Google Scholar 

  6. Stinson, J. C., Jr., Baggenstoss, A. H., andMorlock, C. G. Pancreatic lesions associated with cirrhosis of the liver.Amer J Clin Path 22:117, 1952.

    Google Scholar 

Download references

Author information

Author notes

  1. Beatrice Mulford M.D. (Christian Hospital for Women)

    Present address: Harisinga P. O. Darrang District, Assam, India

Authors and Affiliations

  1. From the Laboratory for Cancer Research and Gastroenterology Section, Department of Medicine, Minneapolis Veterans Hospital, and the University of Minnesota, Minneapolis, Minn.

    Leslie Zieve M.D. & Beatrice Mulford M.D. (Christian Hospital for Women)

Authors
  1. Leslie Zieve M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Beatrice Mulford M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zieve, L., Mulford, B. Secretion of pancreatic enzymes. Digest Dis Sci 12, 303–309 (1967). https://doi.org/10.1007/BF02233649

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02233649

Keywords

Search

Navigation