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Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity

  • Living Pediatrics Symposium in Honour of the 80th Birthday of Professor E. Rossi, Berne, Switzerland
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Abstract

In honour of Professor Rossi's 80th birthday we review the development of our understanding of the immune and auto-immune nature of the pathogenesis of immune thrombocytopenic purpura (ITP). The immune aspects have been documented by postviral alterations of the cellular and humoral immune system, by new methods of specific auto-antibody detection against platelet glycoproteins and by the therapeutic effect of administering immunoglobulin concentrate from healthy blood donors. The various possible mechanisms of action of immunoglobulin treatment have led to use of this treatment as an alternative for other immune-related disorders. The treatment of severe chronic ITP in children, however, remains unsatisfactory. With a new international clinical and laboratory study of children and adolescents with early chronic ITP we are continuing the investigation of the pathogenesis and treatment of ITP.

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Abbreviations

ITP :

immune thrombocytopenic purpura

IVIG :

intravenous immunoglobulin

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Authors and Affiliations

  1. Kinderklinik Aarau, Aarau, Switzerland

    P. Imbach

  2. Universitäts-Kinderspital, Basel, Switzerland

    P. Imbach

  3. The Daisan Hospital, Tokyo, Japan

    J. Akatsuka

  4. Hospital for Sick Children, Toronto 10, Canada

    V. Blanchette

  5. Central Laboratory, SRK, Berne, Switzerland

    A. Burek-Kozlowska & A. Morell

  6. Cornell University, New York, USA

    J. Bussel

  7. Universitäts-Kinderklinik Charlottenburg, Berlin, Germany

    G. Gaedicke

  8. Sandoz, Basel, Switzerland

    A. Gianella-Borradori

  9. Kinderklinik Inselspital, Bern, Switzerland

    E. Gugler, A. Hirt, B. Imholz & H. P. Wagner

  10. Scripps Clinic, La Jolla, California, U.S.A.

    R. McMillan

  11. The London Hospital, London, U.K.

    A. Newland

  12. Children's Hospital, Orange, California, USA

    D. Nugent

  13. Alpine Children's Hospital, Davos, Switzerland

    M. H. Schöni

Authors
  1. P. Imbach
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  2. J. Akatsuka
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  3. V. Blanchette
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  4. A. Burek-Kozlowska
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  5. J. Bussel
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  6. G. Gaedicke
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  7. A. Gianella-Borradori
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  8. E. Gugler
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  9. A. Hirt
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  10. B. Imholz
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  11. R. McMillan
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  12. A. Morell
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  13. A. Newland
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  14. D. Nugent
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  15. M. H. Schöni
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  16. H. P. Wagner
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Imbach, P., Akatsuka, J., Blanchette, V. et al. Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity. Eur J Pediatr 154 (Suppl 4), S60–S64 (1995). https://doi.org/10.1007/BF02191508

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  • DOI: https://doi.org/10.1007/BF02191508

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