Summary
Nucleoside analogs continue to provide a rich source of potent and selective anti-HIV agents. The 5′-triphosphate forms of the clinically useful nucleosides are competitive inhibitors of retroviral reverse transcriptases and can result in the termination of chain elongation of proviral DNA. The function of viral reverse transcriptases and the mechanism of action of various compounds against HIV and hepatitis B virus are discussed. Insights in drug combination and viral resistance to nucleoside analogs are also provided with emphasis on novel enantiomers of nucleosides with the unusuall-configuration.
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Schinazi, R.F. Competitive inhibitors of human immunodeficiency virus reverse transcriptase. Perspectives in Drug Discovery and Design 1, 151–180 (1993). https://doi.org/10.1007/BF02171660
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DOI: https://doi.org/10.1007/BF02171660