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Perspectives on the mitochondrial multiple conductance channel

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Abstract

A multiple conductance channel (MCC) with a peak conductance of over 1 nS is recorded from mitoplasts (mitochondria with the inner membrane exposed) using patch-clamp techniques. MCC shares many general characteristics with other intracellular megachannels, many of which are weakly selective, voltage-dependent, and calcium sensitive. A role in protein import is suggested by the transient blockade of MCC by peptides responsible for targeting mitochondrial precursor proteins. MCC is compared with the peptide-sensitive channel of the outer membrane because of similarities in targeting peptide blockade. The pharmacology and regulation of MCC by physiological effectors are reviewed and compared with the properties of the pore hypothesized to be responsible for the mitochondrial inner membrane permeability transition.

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Authors and Affiliations

  1. Division of Molecular Medicine, Wadsworth Center, Empire State Plaza, P.O. Box 509, 12201-0509, Albany, New York

    Kathleen W. Kinnally & Carmen A. Mannella

  2. Department of Biomedical Sciences, University at Albany, 12201-0509, Albany, New York

    Kathleen W. Kinnally & Carmen A. Mannella

  3. Department of Biological Sciences, University at Albany, 12201-0509, Albany, New York

    Timothy A. Lohret

  4. Departamento Bioquimica y Biologia Molecular y Genética, Universidad de Extremadura, Cáceres, Spain

    Maria Luisa Campo

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  1. Kathleen W. Kinnally
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  4. Carmen A. Mannella
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Kinnally, K.W., Lohret, T.A., Campo, M.L. et al. Perspectives on the mitochondrial multiple conductance channel. J Bioenerg Biomembr 28, 115–123 (1996). https://doi.org/10.1007/BF02110641

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