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Preparation and physical characterization of forms II and III of paracetamol

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Abstract

The polymorphic forms II and III of paracetamol were obtained by melting the marketed form I. Under the melting and cooling conditions used, it was possible to obtain forms I, II and III. The recrystallization conditions and the physical properties of forms II and III were investigated by means of various techniques: thermomicroscopy, DSC analysis, infrared microspectrometry and X-ray powder diffraction at room temperature and as a function of temperature. Form III was found to be very unstable. However, its formation seems to be an important intermediate step in the preparation of form II.

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References

  1. M. Haïsa, S. Kashino, R. Kawasi and H. Maeda, Acta Cryst., B 32 (1976) 1283.

    Google Scholar 

  2. J. M. Welton and G. J. McCarthy, Powder Diffraction, 3, 2 (1988) 102.

    Google Scholar 

  3. M. Haïsa, S. Kashino and H. Maeda, Acta Cryst., B 30 (1974) 2510.

    Google Scholar 

  4. M. Kuhnert Branstätter, M. Geiler and I. Wurian. Sci. Pharm., 48 (1990) 250.

    Google Scholar 

  5. A. Bürger, Acta Pharm. Tech., 28, 1 (1982) 1.

    Google Scholar 

  6. E. Nürnberg and A. Hopp, Pharm. Ind., 44, 10 (1982) 1081.

    Google Scholar 

  7. P. Di Martino, A.-M. Guyot-Hermann, P. Confiant, M. Drache and J.-C. Guyot, Accepted on Int. J. of Pharm., Vol. 127, January 1996.

  8. P. Di Martino, “Polymorphisme du Paracétamol: application à la compression directe”, Thesis, Lille, 1996.

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Authors and Affiliations

  1. Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille II, 1, rue du Professeur Laguesse B.P. 83, 59006, Lille Cedex

    P. Di Martino & A. -M. Guyot-Hermann

  2. URA CNRS 452, Laboratoire de Cristallochimie et Physicochimie du Solide, Ecole Nationale Supérieure de Chimie de Lille, Université des Sciences et Technologies de Lille, France

    P. Conflant & M. Drache

  3. LASIR CNRS USTL, Laboratoire de Spectrochimie Infrarouge et Raman, Université des Sciences et Technologies de Lille, France

    J. -P. Huvenne

Authors
  1. P. Di Martino
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  2. P. Conflant
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  3. M. Drache
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  4. J. -P. Huvenne
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  5. A. -M. Guyot-Hermann
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Additional information

The authors are very grateful to Mrs Laurence Burylo for her kind help with the X-ray diffractograms, and to Mrs. Alexandra Tavernier for her great help with the English translation.

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Di Martino, P., Conflant, P., Drache, M. et al. Preparation and physical characterization of forms II and III of paracetamol. Journal of Thermal Analysis 48, 447–458 (1997). https://doi.org/10.1007/BF01979491

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  • DOI: https://doi.org/10.1007/BF01979491

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