Skip to main content
SpringerLink
Log in

Alterations in the gastro-intestinal functions during the development of adjuvant disease in rats

  • Immunosuppression and Inflammation
  • Review
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Gastric biliary and pancreatic secretions were examined in Lewis rats with adjuvant-induced polyarthritis. By application of the pylorus-ligation technique according to Shay for 4 h, a marked increase in gastric secretion was detected from day 11 to day 54 after adjuvant injection. The changes were manifest by a decrease of pH and an increase of secretory volume as well as total acid output. Maximum values were reached at the 23rd day with an acid secretion 4 times higher than in healthy animals. The enhanced hydrochloric acid secretion in adjuvant arthritic rats was confirmed with the aid of the gastric perfusion technique according to Ghosh and Schild and by the finding that the gastric contents of conscious arthritic rats under standard feeding conditions showed a statistically significant higher acidity (pH 2.5) than normal rats (pH 4.0).

Adjuvant arthrltic rats with acute bile fistulas exhibited a basal and stimulated bile and pancreatic secretion like normal rats.

The gastric mucosa of rats with adjuvant disease is highly sensitive to the irritant effect of gastric hypersecretion in the pylorus-ligation technique. The ulcer rate increases during the progress of the disease with a maximum of 70% at the 37th day. Normal rats with 4 h-pylorus ligation showed no macroscopically visible lesions. Increased sensitivity of the gastric mucosa against the ulcerogenic activity of non-steroidal anti-rheumatic drugs was demonstrated for aspirin and indomethacin. The etiological role of disease stress for the high susceptibility of the arthritic rat to gastric ulceration is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C.M. Pearson,Development of arthritis, periarthritis and periostitis in rats given adjuvant, Proc. Soc. exp. Biol. Med.91, 95 (1956).

    Google Scholar 

  2. B.B. Newbould,Chemotherapy of arthritis induced in rats by mycobacterial adjuvant, Br. J. Pharmac.21, 127–136 (1963).

    Google Scholar 

  3. C.M. Pearson, B.H. Waksman andJ.T. Sharp,Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease, J. exp. Med.113, 485–510 (1961).

    Google Scholar 

  4. R.S. Jones andJ.R. Ward,Studies on adjuvant-induced polyarthritis in rats. II. Histogenesis of joint and visceral lesions, Arthritis Rheum.6, 1, 23–35 (1963).

    Google Scholar 

  5. W.A. Baumgartner, F.W.J. Beck, A. Lorber, C.M. Pearson andM.W. Whitehouse,Adjuvant disease in rats: Biochemical criteria for distinguishing several phases of inflammation and arthritis, Proc. Soc. exp. Biol. Med.145, 625–630 (1974).

    Google Scholar 

  6. M.A. Cawthorne, E.D. Palmer andJ. Green,Adjuvant-induced arthritis and drug-metabolizing enzymes, Biochem. Pharmac.25, 2683–2699 (1976).

    Google Scholar 

  7. P.P. Mathur andR.D. Smyth,The relationship between serum gastrin, gastric ulceration and basal acid output in the polyarthritic rat. J. Pharmac. exp. Ther.212,2, 333–336 (1980).

    Google Scholar 

  8. Z. Zidek andF. Perlik,Genetic control of adjuvant-induced arthritis in rats, J. Pharm. Pharmac.23, 389–390 (1971).

    Google Scholar 

  9. H. Shay, S.A. Komarov, S.S. Fels, D. Meranze, M. Gruenstein andH. Siplet,A simple method for the uniform production of gastric ulceration in rat, Gastroenterology5, 43–61 (1945).

    Google Scholar 

  10. M.N. Ghosh andH.O. Schild,Continuous recording of acid gastric secretion in the rat, Br. J. Pharmac.13, 54–61 (1958).

    Google Scholar 

  11. M.W. Whitehouse andF.J. Beck,Impaired drug metabolism in rats with adjuvant-induced arthritis: A brief review, Am. Soc. Pharm. exp. Ther.1, 251–255 (1973).

    Google Scholar 

  12. P.J. Rooney, W.C. Dick, R.C. Imrie andK.D. Buchanan,Animals model to study the relationship between immunoreactive gastrin and inflammatory arthritis, Nature246, 497–498 (1973).

    Google Scholar 

  13. M. Lavrat andR. Lambert,Experimental ulcers produced in rats by modification of environment, Gastroenterology37, 421–426 (1959).

    Google Scholar 

  14. C.G. van Arman,Pathway to adjuvant arthritis, Fedn. Proc.35, 2442–2445 (1976).

    Google Scholar 

  15. K.D. Rainsford,The role of aspirin in gastric ulceration some factors involved in the development of gastric mucosal damage induced by aspirin in rats exposed to various stress conditions, Digestive Dis.23, 521–530 (1978).

    Google Scholar 

  16. G. Di Pasquale andP. Welja,Ulcerogenic potential of indomethacin in arthritic and non-arthritic rats, J. Pharm. Pharmac.25, 831–832 (1973).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. Pharmacology, Hoechst AG Werk Albert, Postfach 12 91 01, 6200, Wiesbaden 12, West Germany

    R. Schleyerbach & H. Wedde

Authors
  1. R. Schleyerbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Wedde
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

To whom correspondence should be addressed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schleyerbach, R., Wedde, H. Alterations in the gastro-intestinal functions during the development of adjuvant disease in rats. Agents and Actions 15, 392–397 (1984). https://doi.org/10.1007/BF01972377

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01972377

Keywords

Search

Navigation